黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | N-[4-oxo-2-[2-(trifluoromethoxy)phenyl]chromen-8-yl]pyrazine-2-carboxamide | 1219445-24-5 | C21H12F3N3O4 |
|
| —— | 3-(morpholin-4-ylmethyl)-N-[4-oxo-2-[2-(trifluoromethyl)phenyl]chromen-8-yl]benzamide | 1219446-29-3 | C28H23F3N2O4 |
|
| —— | N-[2-(2-chlorophenyl)-4-oxochromen-8-yl]-3-pyrrolidin-1-ylbenzamide | 1219446-30-6 | C26H21ClN2O3 |
|
| —— | N-[2-(2-chlorophenyl)-4-oxochromen-8-yl]-6-(2,3-dihydroxypropoxy)pyridine-2-carboxamide | 1219446-35-1 | C24H19ClN2O6 |
|
| —— | 3-(4-chlorophenyl)sulfonyl-2-(4-methoxyphenyl)-6-methylchromen-4-one | 87127-85-3 | C23H17ClO5S |
|
| —— | 4-<2-Methoxyphenyl>-flavan | 95625-63-1 | C22H20O2 |
|
| —— | 2-(4-Benzyloxy-phenyl)-3,5,6-trihydroxy-7-methoxy-chromen-4-one | 154048-37-0 | C23H18O7 |
|
| —— | 3,3-Biapigeninylhexaacetat | 27090-21-7 | C42H30O16 |
|
| —— | 2-(2-chlorophenyl)-3-(4-chlorophenyl)sulfonyl-6-methylchromen-4-one | 87127-79-5 | C22H14Cl2O4S |
|
| —— | 3,3',4,4',6-Pentaacetoxy-2-phenyl-cumaron | 19858-41-4 | C24H20O11 |
|
| —— | 3,3-bis(4-butoxyphenyl)-5-chloro-6-methoxy-7-hydroxy-10,12-di(trifluoromethyl)-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran | 1380855-35-5 | C45H41ClF6O5 |
|
| —— | 5,7-diacetoxy-2-(3-acetoxy-4,5-dimethoxy-phenyl)-3,8-dimethoxy-chromen-4-one | 21634-50-4 | C25H24O12 |
|
| —— | 5,7,8,2',3'-Pentamethoxy-flavon | 4934-29-6 | C20H20O7 |
|
| —— | 7-Chloro-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran | 139027-54-6 | C15H9ClO3 |
|
| —— | 7,4'-dibenzoyl-3,5-dihydroxyflavone-3-O-β-D-(2'',3'',4''-tri-O-acetyl-6''-O-chloroacetyl)glucopyranoside | 80065-89-0 | C43H39ClO15 |
|
| —— | 2-(3-benzyloxy-4-methoxy-phenyl)-5,7-dihydroxy-3,8-dimethoxy-chromen-4-one | 20921-21-5 | C25H22O8 |
|
| —— | 1-[N-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)]-4-[3-O-methylene-(7,5,4’-trimethoxy flavonol)]-[1,2,3]-triazole | 1467042-70-1 | C35H37N3O15 |
|
| —— | 1224255-86-0 | C24H21BrO9 |
|
|
| —— | 6-[4-(5,7-dimethoxy-4-oxo-chroman-2-yl)-phenoxy]-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one | 34293-19-1 | C35H30O10 |
|
| —— | 5-isopropyl-8-methyl-2-phenyl-2<i>H</i>-chromene | 26506-17-2 | C19H20O |
|
| —— | 1,3-Bis-(2-methoxyphenyl)-1H-naphtho-<2.1-b>pyran | 28656-27-1 | C27H22O3 |
|
| —— | 3-Aethoxy-7.3'.4'-trimethoxy-flav-3-en | 16821-18-4 | C20H22O5 |
|
| —— | 5,6,7,8-Tetrachlor-flav-3-en | 25464-82-8 | C15H8Cl4O |
|
| —— | N-[2-(2-chlorophenyl)-4-oxochromen-8-yl]-2-methylpyrazole-3-carboxamide | 1219446-38-4 | C20H14ClN3O3 |
|
| —— | 1-methyl-N-[4-oxo-2-[2-(trifluoromethyl)phenyl]chromen-8-yl]imidazole-2-carboxamide | 1219445-44-9 | C21H14F3N3O3 |
|
| —— | 5,7-bis-benzyloxy-2-(4-benzyloxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one | 27682-59-3 | C38H32O7 |
|
| —— | (+)-N-[4-(4-oxo-chroman-2-yl)-phenyl]-succinamic acid | 120831-65-4 | C19H17NO5 |
|
| —— | gomphrenol-3-O-β-D-gentiobioside | 1393523-95-9 | C28H30O17 |
|
| —— | 7-(3-bromopropoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one | 1489101-77-0 | C19H17BrO4 |
|
| —— | Toluene-4-sulfonic acid 2-(4-benzyloxy-phenyl)-3,6-dihydroxy-7-methoxy-4-oxo-4H-chromen-5-yl ester | 154048-14-3 | C30H24O9S |
|
| —— | sudachitin 4',7-dibenzyl ether | 70575-21-2 | C32H28O8 |
|
| —— | 8-<2-(3.4-Dimethoxy-phenyl)-5.7-dimethoxy-3-hydroxy-chromanyl-(4)>-5.7.3'.4'-tetramethoxy-3.4-dihydroxy-flavan | 25671-10-7 | C38H42O13 |
|
| —— | 6-Formyl-5-hydroxy-3,3',4',7-tetramethoxyflavon | 54987-72-3 | C20H18O8 |
|
| —— | 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-,(2,4-dinitrophenyl)hydrazone | 902149-22-8 | C23H18N4O7 |
|
| —— | 3(2-Acetoxybenzyl)flavon | 24467-50-3 | C24H18O4 |
|
| —— | 5,6,7-trihydroxy-2-(4-hydroxy-phenyl)-chromenylium | 19353-03-8 | C15H11O5 |
|
| —— | Acetic acid 2-(4-benzyloxy-phenyl)-3,7-dimethoxy-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester | 154047-98-0 | C33H28O10S |
|
| —— | 8-(2-bromo-propyl)-2-(3,4-dimethoxy-phenyl)-7-hydroxy-3-methoxy-chromen-4-one | 102474-43-1 | C21H21BrO6 |
|
| —— | N-[4-oxo-2-[2-(trifluoromethyl)phenyl]chromen-8-yl]-6-(pyrrolidin-1-ylmethyl)pyridine-2-carboxamide | 1219446-19-1 | C27H22F3N3O3 |
|
| —— | 6-Fluor-4'-hydroxy-flavonol | 4257-45-8 | C15H9FO4 |
|
| —— | Pentaacetyl-7-O-methylagathisflavon | 31859-63-9 | C41H30O15 |
|
| —— | N-[2-[2-(difluoromethyl)phenyl]-4-oxochromen-8-yl]-1,3-thiazole-4-carboxamide | 1219445-81-4 | C20H12F2N2O3S |
|
| —— | 6-Aethyl-3,7,2',5'-tetrahydroxy-flavon | 93322-62-4 | C17H14O6 |
|
| —— | 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-en-1-yl)-6-(3-methylbutanoyl)-4H-chromen-4-one | 1443276-37-6 | C25H26O7 |
|
| —— | Ethyl-3'-methoxy-7-flavon-3-ol-oxyacetat | 24700-02-5 | C20H18O7 |
|
| —— | trans-4-chloro-6-methylflavan | 104819-61-6 | C16H15ClO |
|
| —— | (R,Z)-3-((benzylamino)methylene)-2-phenylchroman-4-one | 1430098-11-5 | C23H19NO2 |
|
| —— | 7-{2-[4-(2-chloro-benzyl)-piperazin-1-yl]-ethoxy}-2-phenyl-chromen-4-one | 39576-92-6 | C28H27ClN2O3 |
|
| —— | cis-2,2-Diphenyl-3-benzylidenchromanon | 24467-47-8 | C28H20O2 |
|
| —— | 6-Aethyl-3,2'-dihydroxy-7,5'-dimethoxy-flavon | 94303-30-7 | C19H18O6 |
|
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