黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 4'-(2''-furanyl)flavone | 1417919-73-3 | C19H12O3 |
| —— | (4aS,5S)-9-Chloro-5-(4-chloro-phenyl)-4a,5-dihydro-2H-isochromeno[4,3-b]chromen-7-one | 134164-86-6 | C22H14Cl2O3 |
| —— | 3,5-diethoxy-2-(4-ethoxy-phenyl)-6,7-dimethoxy-chromen-4-one | 29536-42-3 | C23H26O7 |
| —— | 7-(2,4-dimethoxy-phenyl)-8-hydroxy-3-methyl-chromeno[6,5-<i>d</i>]isoxazol-9-one | 49544-00-5 | C19H15NO6 |
| —— | 1250865-61-2 | C18H13ClO5 | |
| —— | 6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-4'-nitroflavone | 1147337-09-4 | C21H21NO8 |
| —— | spiro<5-acetamido-3-acetyl-2,3-dihydro-1,3,4-thiadiazole-2,4'-flavan> | 139061-54-4 | C20H19N3O3S |
| —— | 2-(2-(2-chloro-3-methoxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-yl)acetic acid | 1389342-08-8 | C18H13ClO6 |
| —— | 2-(4-(chloromethyl)-3-methoxyphenyl)-3-hydroxy-6,7-dimethyl-4H-chromen-4-one | 1423119-50-9 | C19H17ClO4 |
| —— | 3-(4-methoxybenzylidene)-4'-methoxyflavanone | 132361-71-8 | C24H20O4 |
| —— | 2H-1-Benzopyran,2-[3,4-bis(phenylmethoxy)phenyl]-8-bromo-3,4-dihydro-3,5,6,7-tetrakis(phenylmethoxy)-, (2R,3S)- | 917567-22-7 | C57H49BrO7 |
| —— | (2S,3R)-3-Chloro-2-(2-chloro-phenyl)-3-nitro-chroman-4-one | 143468-32-0 | C15H9Cl2NO4 |
| —— | Isotachrosin | 42719-69-7 | C23H20O6 |
| —— | 1-{4-[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-3-((2S,3S,4R,5R)-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2,6-dihydroxy-phenyl}-3-(3-hydroxy-4-methoxy-phenyl)-propan-1-one | 61284-29-5 | C27H34O15 |
| —— | 1,2-Dimethyl-2a,8a-dihydro-3-oxa-cyclobuta[b]naphthalen-8-one | 14465-71-5 | C13H12O2 |
| —— | 6-(2-(2-hydroxyethoxy)ethoxy)-4'-methylaminoflavone | 1147337-50-5 | C20H21NO5 |
| —— | 4'-(3''-nitrophenyl)flavone | 1417919-68-6 | C21H13NO4 |
| —— | (+-)-N-(4-oxo-2-phenyl-chroman-6-yl)-succinamic acid | 109811-75-8 | C19H17NO5 |
| —— | 2,3-trans-3,4-trans-4-Phenylsulfonylflavan-3-ol | 55539-50-9 | C21H18O4S |
| —— | 7-benzyloxy-4',5-dihydroxy-3',6,8-trimethoxyflavone 4'-tetra-O-acetyl-β-D-glucopyranoside | 83906-33-6 | C39H40O17 |
| —— | methyl 6-(isobutyryloxy)-2-(4-methoxyphenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate | 1130206-71-1 | C32H28O6 |
| —— | Tephrodinol | 42345-08-4 | C23H20O7 |
| —— | N-(4-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)phenyl)-methanesulfonamide | 685143-66-2 | C19H19NO7S |
| —— | 4'-(3''-trifluoromethylphenyl)flavone | 1417919-66-4 | C22H13F3O2 |
| —— | 2,4-Dihydroxy-6-methoxy-5-methylphenyl-7-hydroxy-5-methoxy-flavan-8-yl-keton | 39827-98-0 | C25H24O7 |
| —— | Acetic acid (2S,3R,4S,5R,6R)-3,5-diacetoxy-2-{3-acetoxy-4-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-5-methoxy-phenoxy}-6-acetoxymethyl-tetrahydro-pyran-4-yl ester | 53669-48-0 | C34H36O16 |
| —— | Methyl-5-O-demethyltephrodinat | 42345-05-1 | C23H22O8 |
| —— | 8-Benzo[1,3]dioxol-5-yl-4,7-dimethyl-pyrano[3,2-g]chromene-2,6-dione | 39818-53-6 | C21H14O6 |
| —— | 1-[3-Methyl-7-(3-Methylbut-2-Enyloxy)Flavon-8-yl]-3-(3-Methoxy)Phenyl-Propen-1-one | 329913-42-0 | C31H28O5 |
| —— | 6-Hydroxy-3-morpholin-4-yl-2-phenylchromen-4-one | 372507-88-5 | C19H17NO4 |
| —— | 7-benzyloxy-6-methoxy-3',4'-methylenedioxyflavone | 70927-90-1 | C24H18O6 |
| —— | 1309872-04-5 | C90H78O14 | |
| —— | (2R,3R)-5-Methoxy-2-(4-methoxy-phenyl)-chroman-3,7-diol | 126595-99-1 | C17H18O5 |
| —— | 2-(3-((E)-3-fluorostyryl)phenyl)-5-methoxy-2,3-dihydrochromen-4-one | 1251022-77-1 | C24H19FO3 |
| —— | 2-(3-((E)-3-methylstyryl)phenyl)-6-chloro-2,3-dihydrochromen-4-one | 1251022-72-6 | C24H19ClO2 |
| —— | 2-<4,6-dimethoxy-2-(methoxymethoxy)phenyl>-4-(4-hydroxyphenyl)-5,7-dimethoxyflavan-3-one | 74628-71-0 | C27H28O9 |
| —— | 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-(3-methyl-butyl)-chromen-4-one | 40073-90-3 | C24H28O7 |
| —— | 7-Benzyloxy-5-hydroxy-2-[3-hydroxy-4-((2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-3-((3S,4R,5R,6S)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one | 53473-11-3 | C34H36O17 |
| —— | 6-Nitro-4'-hydroxy-flavon | 107618-66-6 | C15H9NO5 |
| —— | spectabiflaside decaacetate | 74712-69-9 | C48H52O27 |
| —— | kaempferol 4′-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside | 1169835-58-8 | C27H30O15 |
| —— | 4-(4''-vinylphenyl)flavone | 1417919-70-0 | C23H16O2 |
| —— | 7-Methoxy-3,6''-biflavonyloxymethan | 66075-27-2 | C32H22O7 |
| —— | 2-(2,3-dimethoxy-phenyl)-7,8-dimethoxy-chroman-4-one | 110048-35-6 | C19H20O6 |
| —— | cis-3',4',7-Trimethoxydihydroflavonolacetat | 473975-11-0 | C20H20O7 |
| —— | 4'-(3''-chlorophenyl)flavone | 1417919-71-1 | C21H13ClO2 |
| —— | diethyl 4-[7-{2-(4-hydroxypiperidino)ethoxy}-4H-1-benzopyran-4-on-2-yl]benzylphosphonate | 166305-12-0 | C27H34NO7P |
| —— | 4-(2-Hydroxy-4,6-dimethoxy-phenyl)-6-methyl-2-phenyl-chromen-7-one | 39828-11-0 | C24H20O5 |
| —— | 4'-(3'''-thienyl)flavone | 1417919-74-4 | C19H12O2S |
| —— | 2-(7-hydroxy-4-oxo-2-phenyl-4H-chromen-5-yl)acetic acid | 1389342-15-7 | C17H12O5 |
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