黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | Matteucinol-5-methylaether | 110048-19-6 | C19H20O5 |
| —— | 4β-Acetoxy-tetra-O-methyl-3-O-acetyl-(+)-catechin | 104320-30-1 | C23H26O9 |
| —— | Toluene-4-sulfonic acid 2-(3,4-dimethoxy-phenyl)-3,7-dimethoxy-8-methoxymethoxy-4-oxo-4H-chromen-5-yl ester | 154048-51-8 | C28H28O11S |
| —— | 7,8-dibenzyloxyflavone-4'-carbaldehyde | 700843-51-2 | C30H22O5 |
| —— | 3-hydroxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one | 150717-09-2 | C20H14O4 |
| —— | 1,13-bis[4'-(6-methoxy-4H-chromen-4-on-2-yl)-phenyl]-1,4,7,10,13-pentaoxatridecane | 958458-02-1 | C40H38O11 |
| —— | Acetic acid 3,2',3'-triacetoxy-6'-((2R,3S)-3,5,7-triacetoxy-chroman-2-yl)-6-((2R,3R)-3,5,7-triacetoxy-4-oxo-chroman-2-yl)-biphenyl-2-yl ester | 111024-98-7 | C50H44O23 |
| —— | Tetra-O-methyl-3-O-pivaloyl-(+)-catechin | 131266-29-0 | C24H30O7 |
| —— | 4-[(2R,3R,4S)-4-Methyl-7-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-chroman-2-yl]-phenol | 783342-69-8 | C40H60O4Si2 |
| —— | 4β-(S-L-cysteinyl)-(-)-epicatechin gallate-(4β→8)-(-)-epicatechin gallate | 800374-21-4 | C47H39NO24S |
| —— | 2-chloro-7-imino-10-methyl-6a-nitro-6,9-diphenyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene-8-carbonitrile | 1248412-52-3 | C27H20ClN3O3 |
| —— | 4'-Chlor-8-hydroxy-flavanon | 108718-32-7 | C15H11ClO3 |
| —— | 8-Acetoxy-6-methyl-3-ethyl-flavon | 94549-73-2 | C20H18O4 |
| —— | 4'-Methoxy-6-methyl-8-brom-flavanon | 29976-74-7 | C17H15BrO3 |
| —— | 8-Methoxy-7-benzoyloxy-6-allyl-flavon | 96003-02-0 | C26H20O5 |
| —— | 7-((3-methylbenzyl)oxy)-4-oxo-2-phenyl-4H-chromene-3,5-diyl diacetate | 1254040-79-3 | C27H22O7 |
| —— | 4β-(S-cysteinyl)epigallocatechin 3-O-gallate | 800374-20-3 | C25H23NO13S |
| —— | Isoginkgetin-tetraaethylaether | 107527-17-3 | C40H38O10 |
| —— | Dihydroquercetin-phenylhydrazon | 94872-12-5 | C21H18N2O6 |
| —— | 7-Hydroxyflavon-6-carbonsaeure | 37042-27-6 | C16H10O5 |
| —— | 6,8,3'-Trimethoxy-3-hydroxy-flavon | 93876-55-2 | C18H16O6 |
| —— | 7-Acetoxy-5-methyl-3'.4'-dioxymethylen-flavon | 110939-54-3 | C19H14O6 |
| —— | 2'.4'-Dichlor-7-methoxy-flavonol | 92791-87-2 | C16H10Cl2O4 |
| —— | 5-methyl-7-(3,4,5-trimethoxyphenyl)-5H-indeno<5,6-d>-1,3-dioxol-5-ol | 94671-16-6 | C20H20O6 |
| —— | 3,7,8-Trimethoxy-5-acetoxy-flavon | 22399-76-4 | C20H18O7 |
| —— | 3-formyl-4-methoxy-flav-3-ene | 99943-46-1 | C17H14O3 |
| —— | 1-[N-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)]-4-[3-O-methylene-(7,5,4’-tribenzyl flavonol)]-[1,2,3]-triazole | 1469989-91-0 | C53H49N3O15 |
| —— | penta-O-acetyl-(+)-catechin-(4β,2)-tri-O-acetylphloroglucinol | 61541-07-9 | C37H34O17 |
| —— | [(2S,3S,4R,5R,6S)-4,5-dibenzoyloxy-6-[(2S,3R,4S,5S)-4,5-diacetyloxy-2-[5-acetyloxy-2-(4-acetyloxy-3-hydroxyphenyl)-4-oxo-7-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxychromen-3-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl] benzoate | 616201-24-2 | C69H66O31 |
| —— | Acetic acid 7-acetoxy-3,8-dimethoxy-4-oxo-2-phenyl-4H-chromen-5-yl ester | 33803-38-2 | C21H18O8 |
| —— | 6,8-Dimethoxy-3-hydroxy-flavon | 93322-41-9 | C17H14O5 |
| —— | 6-chloromethyl-5-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-chromen-4-one | 742097-95-6 | C18H15ClO5 |
| —— | 3,2'-Dihydroxy-flavon-6-carbonsaeure | 92796-17-3 | C16H10O6 |
| —— | 7-Hydroxy-8-ethyliminomethyl-3-ethyl-flavon | 88827-65-0 | C20H19NO3 |
| —— | 3-Hydroxy-2-<4-hydroxy-phenyl>-6-benzoyl-chromon | 113058-15-4 | C22H14O5 |
| —— | 8-acetylamino-2-(4-ethoxy-phenyl)-chroman-4-one | 101890-68-0 | C19H19NO4 |
| —— | ethyl 8-(4-hydroxyphenyl)-2-(4-piperidinophenyl)-2-phenyl-2H-naphtho[1,2-b]pyran-5-carboxylate | 1021906-59-1 | C39H35NO4 |
| —— | (2R,3S)-6-Chloro-3-hydroxy-2-phenyl-chroman-4-one | 139006-41-0 | C15H11ClO3 |
| —— | 7-Chlorcarbonylmethoxy-4-oxo-2-phenyl-4H-chromen | 98221-24-0 | C17H11ClO4 |
| —— | 4β-Hydroxy-tri-O-methyl-3-O-acetyl-(-)-fisetinidol-(4α,8)-tetra-O-methyl-3-O-acetyl-(+)-catechin | 131266-32-5 | C41H44O14 |
| —— | 3-bromo-5-hydroxy-2-(4-methoxy-phenyl)-6-nitro-chroman-4-one | 133131-61-0 | C16H12BrNO6 |
| —— | Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-(3,4-dihydroxy-phenyl)-5-hydroxy-3-methoxy-4-oxo-4H-chromen-7-yloxy]-tetrahydro-pyran-3-yl ester | 13454-25-6 | C30H30O16 |
| —— | 2,7-dimethyl-4-phenyl-benzo[<i>b</i>]oxepine-3,5-dione | 58065-54-6 | C18H16O3 |
| —— | 6-Iod-3',4'-methylendioxy-flavon | 130986-54-8 | C16H9IO4 |
| —— | 4-(2,4-Diacetoxy-phenyl)-flavan | 95817-37-1 | C25H22O5 |
| —— | 6-chloro-2-phenyl-3-(phenylselanyl)-4H-chromen-4-one | 1332698-13-1 | C21H13ClO2Se |
| —— | 2-(benzo[d][1,3]dioxol-4-yl)-4H-chromen-4-one | 339563-99-4 | C16H10O4 |
| —— | 4',5,7-trihydroxy-flavanoe benzoyl hydrazone | 882033-75-2 | C22H18N2O5 |
| —— | 1-(N-β-D-galactopyranosyl)-4-[3-O-methylene-(7,5,4’-trihydroxy flavonol)]-[1,2,3]-triazole | 1469990-10-0 | C24H23N3O11 |
| —— | 1-[N-(2,3,4,6-tetra-O-acetyl-β-D-glucotopyranosyl)]-4-[3-O-methylene-(7,5,4’-trihydroxy flavonol)]-[1,2,3]-triazole | 1469989-99-8 | C32H31N3O15 |
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