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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 黄酮类化合物

    黄酮类化合物

    黄酮类化合物 定义与结构特征

    黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。

    生物来源

    黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

    化学性质 亲水性与溶解度

    由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。

    稳定性与光敏性

    大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。

    生理活性与药用价值

    黄酮类化合物因其丰富的生理活性而备受关注，主要包括：

    • 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
    • 抗炎效应：有助于减轻炎症反应，缓解症状。
    • 心血管保护：可能通过多种机制改善心脑血管健康。
    • 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
    应用领域 食品工业

    作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。

    化妆品行业

    利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。

    药物开发

    由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S,3R,4S)-4α-(2,4,6-trihydroxyphenyl)flavan-3,3',4',7-tetraol 125090-60-0 C21H18O8
    (2S,3R,4S)-4α-(2,4,6-trihydroxyphenyl)flavan-3,3',4',7-tetraol
    —— 3-(benzenesulfonyl)-2-(2-chlorophenyl)-6-methylchromen-4-one 87127-67-1 C22H15ClO4S
    3-(benzenesulfonyl)-2-(2-chlorophenyl)-6-methylchromen-4-one
    —— 2-(3-chloro-phenyl)-7-hydroxy-chroman-4-one 36745-29-6 C15H11ClO3
    2-(3-chloro-phenyl)-7-hydroxy-chroman-4-one
    —— 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carbonitrile 101439-67-2 C17H11NO2
    3-methyl-4-oxo-2-phenyl-4H-chromene-8-carbonitrile
    —— 10-methyl-3,3-diphenyl-3H-naphtho<2.1-b>pyran 157945-90-9 C26H20O
    10-methyl-3,3-diphenyl-3H-naphtho<2.1-b>pyran
    —— 2-Phenyl-γ-pyrono(6,7)benzisoxazol 49586-06-3 C17H11NO3
    2-Phenyl-γ-pyrono(6,7)benzisoxazol
    —— 2-[6-amino-3-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-1λ6-isothiazolidin-1,1-dione 372103-08-7 C18H16N2O6S
    2-[6-amino-3-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-1λ6-isothiazolidin-1,1-dione
    —— tert-butyl (R)-3-hydroxy-3-[(S)-2-(p-methoxyphenyl)-8-methoxy-2H-chromen-3-yl]propanoate 1101850-46-7 C24H28O6
    tert-butyl (R)-3-hydroxy-3-[(S)-2-(p-methoxyphenyl)-8-methoxy-2H-chromen-3-yl]propanoate
    —— Kazinol U 1238116-48-7 C20H22O4
    Kazinol U
    —— 3,5,7-Trimethoxy-2-[3-methoxy-4-((2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one 50991-81-6 C29H36O12
    3,5,7-Trimethoxy-2-[3-methoxy-4-((2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one
    —— 7-O-(Morpholinoethyl)-3'-O-cyclopentyldiosmetin 205524-16-9 C27H31NO7
    7-O-(Morpholinoethyl)-3'-O-cyclopentyldiosmetin
    —— 7-(benzyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one 116222-56-1 C23H20O6
    7-(benzyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
    —— 6-Nitro-5-acetoxy-flavon 93329-06-7 C17H11NO6
    6-Nitro-5-acetoxy-flavon
    —— 5-O-acetyl-3',4',7'-tri-O-methylluteolin 31794-09-9 C20H18O7
    5-O-acetyl-3',4',7'-tri-O-methylluteolin
    —— 1-(7-Hydroxy-2-phenyl-chroman-6-yl)-3-(4-methoxy-phenyl)-propan-1-one 112777-04-5 C25H24O4
    1-(7-Hydroxy-2-phenyl-chroman-6-yl)-3-(4-methoxy-phenyl)-propan-1-one
    —— 2-(1-(4-amino-3-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one 1408085-82-4 C27H24F2N6O2
    2-(1-(4-amino-3-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
    —— 2-[2-(2-trifluoromethylphenyl)chroman-6-yloxy]-5-nitropyridine 728934-56-3 C21H15F3N2O4
    2-[2-(2-trifluoromethylphenyl)chroman-6-yloxy]-5-nitropyridine
    —— 4'-Benzyleriodictyol 4049-40-5 C22H18O6
    4'-Benzyleriodictyol
    —— 2-[2-(3-chloro-4-fluorophenyl)chroman-6-yloxy]-5-nitropyridine 728934-60-9 C20H14ClFN2O4
    2-[2-(3-chloro-4-fluorophenyl)chroman-6-yloxy]-5-nitropyridine
    —— 2-(3,4-Bis-benzyloxy-phenyl)-3-decyl-5,7,8-trimethoxy-chromen-4-one 134109-93-6 C42H48O7
    2-(3,4-Bis-benzyloxy-phenyl)-3-decyl-5,7,8-trimethoxy-chromen-4-one
    —— 2-(2-chlorophenyl)-4-oxo-4H-chromene-3-carbonitrile 1384106-89-1 C16H8ClNO2
    2-(2-chlorophenyl)-4-oxo-4H-chromene-3-carbonitrile
    —— 2-phenyl-pyrano[3,2-c]quinolin-4-one 98596-21-5 C18H11NO2
    2-phenyl-pyrano[3,2-c]quinolin-4-one
    —— 2'-(2,3-di-O-acetyl-β-D-glucopyranosyloxy)-6'-acetoxy-3-(5-benzo[b]furanyl)propiophenone 174456-37-2 C29H30O12
    2'-(2,3-di-O-acetyl-β-D-glucopyranosyloxy)-6'-acetoxy-3-(5-benzo[b]furanyl)propiophenone
    —— 6-chloro-3-hydroxy-7-methyl-2-naphthalen-1-ylchromen-4-one 141213-90-3 C20H13ClO3
    6-chloro-3-hydroxy-7-methyl-2-naphthalen-1-ylchromen-4-one
    —— (S)-2,8-bis-(tert-butyldimethylsilanyloxy)-5-[4-(3-iodo-propoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene 1157856-68-2 C38H51IO5Si2
    (S)-2,8-bis-(tert-butyldimethylsilanyloxy)-5-[4-(3-iodo-propoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene
    —— 6,7-difluoro-3-iodo-2-phenyl-chromen-4-one 1279087-97-6 C15H7F2IO2
    6,7-difluoro-3-iodo-2-phenyl-chromen-4-one
    —— 3-(N-2-hydroxyphenyl)aminomethylidene-flavanone 99111-21-4 C22H17NO3
    3-(N-2-hydroxyphenyl)aminomethylidene-flavanone
    —— 2-(4-dimethylaminophenyl)-6-methoxy-7-(N-morpholinyl)-2,13,13-triphenyl-2H,13H-indeno[1,2-h]benzo[f]chromene 404934-60-7 C51H44N2O3
    2-(4-dimethylaminophenyl)-6-methoxy-7-(N-morpholinyl)-2,13,13-triphenyl-2H,13H-indeno[1,2-h]benzo[f]chromene
    —— N-{3-(benzyloxy)-2-[4-(benzyloxy)phenyl]-8-nitro-4oxo-4H-chromen-6yl}acetamide 372102-84-6 C31H24N2O7
    N-{3-(benzyloxy)-2-[4-(benzyloxy)phenyl]-8-nitro-4oxo-4H-chromen-6yl}acetamide
    —— 1233322-00-3 C23H22O4
    —— 3-Methanesulfonyl-4-(4-methoxy-phenyl)-2-methyl-1,2,3,3a,4,9b-hexahydro-chromeno[3,4-b]pyrrole-1-carboxylic acid methyl ester 133765-36-3 C22H25NO6S
    3-Methanesulfonyl-4-(4-methoxy-phenyl)-2-methyl-1,2,3,3a,4,9b-hexahydro-chromeno[3,4-b]pyrrole-1-carboxylic acid methyl ester
    —— 1263317-93-6 C46H48O4S2
    —— 3,8-dibromo-7-butoxy-2-(4-methylphenyl)-6-nitrochromen-4-one 139589-39-2 C20H17Br2NO5
    3,8-dibromo-7-butoxy-2-(4-methylphenyl)-6-nitrochromen-4-one
    —— 3-acetoxy-2,3,4'-trimethoxyflavan-4-one 344578-81-0 C20H20O7
    3-acetoxy-2,3,4'-trimethoxyflavan-4-one
    —— 2-(2-(2-chlorophenyl)chroman-4-ylidene)hydrazine-1-carboxamide 534569-41-0 C16H14ClN3O2
    2-(2-(2-chlorophenyl)chroman-4-ylidene)hydrazine-1-carboxamide
    —— 3-acetoxy-2-(3,4-diacetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 114889-48-4 C22H18O10
    3-acetoxy-2-(3,4-diacetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one
    —— 3-(3-methoxyphenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one 28656-20-4 C20H16O3
    3-(3-methoxyphenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one
    —— {2-(4-iodo-phenyl)-6-(tetrahydro-pyran-2-yloxy)-3-[4-(tetrahydro-pyran-2-yloxy)phenyl]-4-trifluoromethyl-chroman-4-yloxy}trimethyl-silane 1352306-41-2 C35H40F3IO6Si
    {2-(4-iodo-phenyl)-6-(tetrahydro-pyran-2-yloxy)-3-[4-(tetrahydro-pyran-2-yloxy)phenyl]-4-trifluoromethyl-chroman-4-yloxy}trimethyl-silane
    —— (S)-3-(4-fluorophenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol 1352307-42-6 C30H32FNO3
    (S)-3-(4-fluorophenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol
    —— 1400900-17-5 C31H26ClNO4S
    —— 7-chloro-2-(3,4-dichlorophenyl)-4-(propylimino)-4H-chromen-5-ol 1262129-50-9 C18H14Cl3NO2
    7-chloro-2-(3,4-dichlorophenyl)-4-(propylimino)-4H-chromen-5-ol
    —— 1333408-75-5 C26H18ClFO4
    —— (4R)-3,3-dimethyl-4-(nitromethyl)chroman-2-ol 1264757-61-0 C12H15NO4
    (4R)-3,3-dimethyl-4-(nitromethyl)chroman-2-ol
    —— 1352172-04-3 C41H28N6O7
    —— (1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea 373632-32-7 C24H22F2N2O4
    (1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea
    —— 1a,7a-Dihydro-4,5-dimethoxy-7(1H)-(2-methylaminoethyloxyimino)-1a-phenylcyclopropa[b]chromen 139771-02-1 C21H24N2O4
    1a,7a-Dihydro-4,5-dimethoxy-7(1H)-(2-methylaminoethyloxyimino)-1a-phenylcyclopropa[b]chromen
    —— 5-hydroxy-4'-aminoflavone 1257513-93-1 C15H11NO3
    5-hydroxy-4'-aminoflavone
    —— ent-Fisetinidol-(4β,8)-catechin hepta-O-methyl ether 78185-21-4 C37H40O11
    ent-Fisetinidol-(4β,8)-catechin hepta-O-methyl ether
    —— 1453812-66-2 C15H9FO3
    —— 7,2',4'-Trihydroxyflavylium-chlorid 97320-19-9 C15H11O4*Cl
    7,2',4'-Trihydroxyflavylium-chlorid