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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-((chloromethyl)thio)thiazole —— C4H4ClNS2
    2-((chloromethyl)thio)thiazole
    —— 5-(N-isopropyl-N-methylsulfamoyl)-2-((4-methoxyphenyl)thio)benzoic acid —— C18H21NO5S2
    5-(N-isopropyl-N-methylsulfamoyl)-2-((4-methoxyphenyl)thio)benzoic acid
    —— (1-phenylethyl)(o-tolyl)sulfane —— C15H16S
    (1-phenylethyl)(o-tolyl)sulfane
    —— (4-fluorophenyl)(1-phenylethyl)sulfane —— C14H13FS
    (4-fluorophenyl)(1-phenylethyl)sulfane
    —— mesityl propargyl sulfide —— C12H14S
    mesityl propargyl sulfide
    —— trimethylsilyl-(13)C-methyl-phenylsulfide —— C10H16SSi
    trimethylsilyl-(13)C-methyl-phenylsulfide
    —— N-(7-bromo-6-oxoheptyl)-2-(4-fluorophenylthio)acetamide —— C15H19BrFNO2S
    N-(7-bromo-6-oxoheptyl)-2-(4-fluorophenylthio)acetamide
    —— 2-(Ethylthio)-3,6-dihydro-6-oxo-1,3,5-triphenyl-1-pyrimidinium-4-olat —— C24H20N2O2S
    2-(Ethylthio)-3,6-dihydro-6-oxo-1,3,5-triphenyl-1-pyrimidinium-4-olat
    —— 6-(2-azidomethyl-phenylsulfanyl)-3-isoprolyl-[1,2,4]triazolo[4,3-a]pyridine —— C16H16N6S
    6-(2-azidomethyl-phenylsulfanyl)-3-isoprolyl-[1,2,4]triazolo[4,3-a]pyridine
    —— hydroxyethyl octyl sulfide —— C10H22OS
    hydroxyethyl octyl sulfide
    —— (4R,5S,6R)-3,4,5,6-tetrahydro-3-[(2S,3S)-3-hydroxy-3-phenyl-2-((phenylthio)methyl)propionyl]-4-isopropyl-5-methyl-6-phenyl-2H-1,3,4-oxadiazin-2-one —— C29H32N2O4S
    (4R,5S,6R)-3,4,5,6-tetrahydro-3-[(2S,3S)-3-hydroxy-3-phenyl-2-((phenylthio)methyl)propionyl]-4-isopropyl-5-methyl-6-phenyl-2H-1,3,4-oxadiazin-2-one
    —— 2,4-dimethylthiopyrimidine-5-boronic acid —— C6H9BN2O2S2
    2,4-dimethylthiopyrimidine-5-boronic acid
    —— 2-(3-benzyloxypropyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1H-imidazole —— C22H24Cl2N2OS
    2-(3-benzyloxypropyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1H-imidazole
    —— 2-(3-benzyloxypropyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1-ethyl-1H-imidazole —— C24H28Cl2N2OS
    2-(3-benzyloxypropyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1-ethyl-1H-imidazole
    —— (4S,5S)-4-methyl-2-(2-methyl-1,3-dithian-2-yl)-5-phenyl-4,5-dihydro-1,3-oxazole —— C15H19NOS2
    (4S,5S)-4-methyl-2-(2-methyl-1,3-dithian-2-yl)-5-phenyl-4,5-dihydro-1,3-oxazole
    —— 2-methylthio-4-(4'-aminophenylarsonic acid)aminopyrimidine 296235-31-9 C11H12AsN3O3S
    2-methylthio-4-(4'-aminophenylarsonic acid)aminopyrimidine
    —— 1,1-dioxo-2-methyl-2,3-dihydrobenzo[e][1,4,2]dithiazine-3-thione —— C8H7NO2S3
    1,1-dioxo-2-methyl-2,3-dihydrobenzo[e][1,4,2]dithiazine-3-thione
    —— 1,1-dioxo-2-methyl-2,3-dihydrobenzo[e][1,4,2]dithiazine-3-one —— C8H7NO3S2
    1,1-dioxo-2-methyl-2,3-dihydrobenzo[e][1,4,2]dithiazine-3-one
    —— 5-(2-hydroxyethyl)-6-methyl-2-[(1-methyl-2-oxopropyl)thio]-4(3H)-pyrimidinone —— C11H16N2O3S
    5-(2-hydroxyethyl)-6-methyl-2-[(1-methyl-2-oxopropyl)thio]-4(3H)-pyrimidinone
    —— (E)-2-[(methylamino)phenylmethylene]-benzo[b]thiophen-3(2H)-one —— C16H13NOS
    (E)-2-[(methylamino)phenylmethylene]-benzo[b]thiophen-3(2H)-one
    —— (4 hydroxyphenylthio)nitromethane —— C7H7NO3S
    (4 hydroxyphenylthio)nitromethane
    —— N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)piperidine-1-sulfonamide —— C19H25F2N5O3S2
    N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)piperidine-1-sulfonamide
    —— N-{6-chloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4-yl}-2-(dimethylamino)ethanesulfonamide —— C15H17Cl2FN4O2S2
    N-{6-chloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4-yl}-2-(dimethylamino)ethanesulfonamide
    —— N-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-2-(dimethylamino)ethanesulfonamide —— C18H25ClFN5O3S2
    N-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-2-(dimethylamino)ethanesulfonamide
    —— dimethyl-dithiocarbamic acid thiophen-3-yl ester —— C7H9NS3
    dimethyl-dithiocarbamic acid thiophen-3-yl ester
    —— N-[2-(benzylthio)-6-chloropyrimidin-4-yl]-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide —— C18H26ClN3O3S2Si
    N-[2-(benzylthio)-6-chloropyrimidin-4-yl]-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide
    —— N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide —— C17H21F2N5O3S2
    N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide
    —— N-{6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidin-4-yl}-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide —— C20H27ClF2N4O3S2Si
    N-{6-chloro-2-[(2,3-difluorobenzyl)thio]pyrimidin-4-yl}-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide
    —— dimethyl dithiocarbamic acid thiophen-2-yl ester —— C7H9NS3
    dimethyl dithiocarbamic acid thiophen-2-yl ester
    —— N-(2-[(2-fluoro-3-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)methanesulfonamide —— C16H21FN4O3S2
    N-(2-[(2-fluoro-3-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)methanesulfonamide
    —— N'-[2-(benzylthio)-6-chloropyrimidin-4-yl]-N,N-dimethylsulfamide —— C13H15ClN4O2S2
    N'-[2-(benzylthio)-6-chloropyrimidin-4-yl]-N,N-dimethylsulfamide
    —— N'-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N,N-dimethylsulfamide —— C16H23N5O3S2
    N'-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N,N-dimethylsulfamide
    —— (2R)-2-{[6-amino-2-(benzylthio)pyrimidin-4-yl]amino}propan-1-ol —— C14H18N4OS
    (2R)-2-{[6-amino-2-(benzylthio)pyrimidin-4-yl]amino}propan-1-ol
    —— N'-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N,N-dimethylsulfamide —— C16H21ClFN5O3S2
    N'-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N,N-dimethylsulfamide
    —— N'-{6-chloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4-yl}-N,N-dimethylsulfamide —— C13H13Cl2FN4O2S2
    N'-{6-chloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4-yl}-N,N-dimethylsulfamide
    —— 1-cyclohexyl-2-(dimethyl(oxo)-λ<sup>6</sup>-sulfanylidene)ethan-1-one —— C10H18O2S
    1-cyclohexyl-2-(dimethyl(oxo)-λ<sup>6</sup>-sulfanylidene)ethan-1-one
    —— 1-(2,3-dihydroimidazo<2,1-b>thiazol-6-yl)ethanone —— C7H8N2OS
    1-(2,3-dihydroimidazo<2,1-b>thiazol-6-yl)ethanone
    —— 5,5,6,6-tetrafluoro-6-(phenylthio)hexan-2-one —— C12H12F4OS
    5,5,6,6-tetrafluoro-6-(phenylthio)hexan-2-one
    —— (1'S)-N-1'-phenylethyl-Z-3-chloro-2-(phenylthio)-2-pentenamide —— C19H20ClNOS
    (1'S)-N-1'-phenylethyl-Z-3-chloro-2-(phenylthio)-2-pentenamide
    —— (S)-N-1'-phenylethyl-E-3-chloro-2-(phenylthio)-2-pentenamide —— C19H20ClNOS
    (S)-N-1'-phenylethyl-E-3-chloro-2-(phenylthio)-2-pentenamide
    —— 3-tert-butyl-2-hydroxy-5-[(4-methoxyphenyl)thio]-6-methylbenzoic acid —— C19H22O4S
    3-tert-butyl-2-hydroxy-5-[(4-methoxyphenyl)thio]-6-methylbenzoic acid
    —— 4-(4-bromophenylthio)butan-2-one —— C10H11BrOS
    4-(4-bromophenylthio)butan-2-one
    —— 1-(2-methylthioimidazol-1-yl)-2-(imidazol-1-yl)ethane —— C9H12N4S
    1-(2-methylthioimidazol-1-yl)-2-(imidazol-1-yl)ethane
    —— 1,2-bis(methylthioimidazol-1-yl)ethane —— C10H14N4S2
    1,2-bis(methylthioimidazol-1-yl)ethane
    —— (1R,5R)-8,8-dimethyl-1-phenylsulfanylmethyl-2-aza-bicyclo[3.2.1]octane —— C16H23NS
    (1R,5R)-8,8-dimethyl-1-phenylsulfanylmethyl-2-aza-bicyclo[3.2.1]octane
    —— 3-(ethylsulfinyl)-2-methylprop-1-ene —— C6H12OS
    3-(ethylsulfinyl)-2-methylprop-1-ene
    —— (+/-)-(3R,4R)-3-(phenylthio)methyl-4-heptanol —— C14H22OS
    (+/-)-(3R,4R)-3-(phenylthio)methyl-4-heptanol
    —— (+/-)-(3S,4R)-3-(phenylthio)methyl-4-decanol —— C17H28OS
    (+/-)-(3S,4R)-3-(phenylthio)methyl-4-decanol
    —— 1-(Octadec-9-(E)-en-1ylaminocarbonylmethyl)-2-(4-fluorobenzyl)thio-5-(pyrimid-5-ylmethyl)pyrimidin-4-one —— C36H50FN5O2S
    1-(Octadec-9-(E)-en-1ylaminocarbonylmethyl)-2-(4-fluorobenzyl)thio-5-(pyrimid-5-ylmethyl)pyrimidin-4-one
    —— 1-(3-(Octadec-9-(E)-en-1ylaminocarbonyl)prop-1-yl)-2-(4-fluorobenzyl)thio-5-(pyrimid-5-ylmethyl)pyrimidin-4-one —— C38H54FN5O2S
    1-(3-(Octadec-9-(E)-en-1ylaminocarbonyl)prop-1-yl)-2-(4-fluorobenzyl)thio-5-(pyrimid-5-ylmethyl)pyrimidin-4-one