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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-(pyrimidin-2-ylthio)butanenitrile —— C8H9N3S
    4-(pyrimidin-2-ylthio)butanenitrile
    —— N,N-diethyl-3-[(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)thio]1H-1,2,4-triazole-1-carboxamide —— C14H22N6OS
    N,N-diethyl-3-[(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)thio]1H-1,2,4-triazole-1-carboxamide
    —— 2-Cyanomethyl-5-cyanomethylene-3,3,6,6-tetramethyl-2-(2-pyrimidylthio)-1,4-oxathiane —— C16H18N4OS2
    2-Cyanomethyl-5-cyanomethylene-3,3,6,6-tetramethyl-2-(2-pyrimidylthio)-1,4-oxathiane
    —— 2-(3,3,3-trifluoro-1-pentafluoroethyl-2-trifluoromethyl-1-propenylsulfanyl)pyrimidine —— C10H3F11N2S
    2-(3,3,3-trifluoro-1-pentafluoroethyl-2-trifluoromethyl-1-propenylsulfanyl)pyrimidine
    —— 2-Cyanomethyl-5-cyanomethylene-3,3,6,6-tetramethyl-2-(2-pyrimidylthio)-1,4-dioxane —— C16H18N4O2S
    2-Cyanomethyl-5-cyanomethylene-3,3,6,6-tetramethyl-2-(2-pyrimidylthio)-1,4-dioxane
    —— 2-((S)-cyclohept-2-enylsulfanyl)-pyrimidine —— C11H14N2S
    2-((S)-cyclohept-2-enylsulfanyl)-pyrimidine
    —— Ethyl 2-((pyrimid-2-yl)thio)acetoacetate (aminocarbonyl)hydrazone —— C11H15N5O3S
    Ethyl 2-((pyrimid-2-yl)thio)acetoacetate (aminocarbonyl)hydrazone
    —— Methyl 2-((pyrimid-2-yl)thio)acetoacetate (aminocarbonyl)hydrazone —— C10H13N5O3S
    Methyl 2-((pyrimid-2-yl)thio)acetoacetate (aminocarbonyl)hydrazone
    —— 2-(2-adamantan-1-yl-ethylsulfanyl)-pyrimidine —— C16H22N2S
    2-(2-adamantan-1-yl-ethylsulfanyl)-pyrimidine
    —— 6-(2-Amino-4,5-dimethylphenyl)thiouracil —— C12H13N3O2S
    6-(2-Amino-4,5-dimethylphenyl)thiouracil
    —— 1-diethylcarbamoyl-3-cyclopropylmethylthio-1,2,4-triazole —— C11H18N4OS
    1-diethylcarbamoyl-3-cyclopropylmethylthio-1,2,4-triazole
    —— 2-((R,E)-1-ethyl-pent-2-enylsulfanyl)-pyrimidine —— C11H16N2S
    2-((R,E)-1-ethyl-pent-2-enylsulfanyl)-pyrimidine
    —— 2,2,4,5-Tetrachlor-1,3-dithiol-1,1,3,3-tetraoxid —— C3Cl4O4S2
    2,2,4,5-Tetrachlor-1,3-dithiol-1,1,3,3-tetraoxid
    —— N-(2-(phenylthio)phenyl)pivalamide —— C17H19NOS
    N-(2-(phenylthio)phenyl)pivalamide
    —— methyl 2-(pyrimidin-2-ylthio)acetate —— C7H8N2O2S
    methyl 2-(pyrimidin-2-ylthio)acetate
    —— 2-((trifluoromethyl)thio)pyrimidine —— C5H3F3N2S
    2-((trifluoromethyl)thio)pyrimidine
    —— methyl 3-(Pyrimidin-2-ylthio)propionate —— C8H10N2O2S
    methyl 3-(Pyrimidin-2-ylthio)propionate
    —— 8-benzyl-2-(propylthio)-4-(pyrimidin-2-ylthio)pteridin-7(8H)-one —— C20H18N6OS2
    8-benzyl-2-(propylthio)-4-(pyrimidin-2-ylthio)pteridin-7(8H)-one
    —— ethyl α-fluoro-α-[(2-pyrimidyl)thio]acetate —— C8H9FN2O2S
    ethyl α-fluoro-α-[(2-pyrimidyl)thio]acetate
    —— S-pyrimidin-2-yl 2,2-dimethylpropanethioate —— C9H12N2OS
    S-pyrimidin-2-yl 2,2-dimethylpropanethioate
    —— 2-((2,2-dimethylpent-4-en-1-yl)thio)pyrimidine —— C11H16N2S
    2-((2,2-dimethylpent-4-en-1-yl)thio)pyrimidine
    —— 6,7-bis(2-methoxyethoxy)-4-(pyrimidin-2-ylthio)quinazoline —— C18H20N4O4S
    6,7-bis(2-methoxyethoxy)-4-(pyrimidin-2-ylthio)quinazoline
    —— 4-amino-6-chloro-2-[(5-chlorothiophen-2-ylmethyl)thio]pyrimidine —— C9H7Cl2N3S2
    4-amino-6-chloro-2-[(5-chlorothiophen-2-ylmethyl)thio]pyrimidine
    —— 3-(2-methylbenzylthio)-5,6-diphenyl-1,2,4-triazine —— C23H19N3S
    3-(2-methylbenzylthio)-5,6-diphenyl-1,2,4-triazine
    —— 5-(2,6-difluorophenyl)aminomethyl-4-methylamino-2-methylthiopyrimidine —— C13H14F2N4S
    5-(2,6-difluorophenyl)aminomethyl-4-methylamino-2-methylthiopyrimidine
    —— trans vinyl sulfone —— C2H4O2S
    trans vinyl sulfone
    —— 4,6-dimethyl-2-{[(2-methylphenyl)methyl]sulfanyl}pyridine-3-carbonitrile —— C16H16N2S
    4,6-dimethyl-2-{[(2-methylphenyl)methyl]sulfanyl}pyridine-3-carbonitrile
    —— 3-chloro-benzo[<i>b</i>]pyrido[2,3-<i>e</i>][1,4]thiazine-10-carboxylic acid 3-piperidin-1-yl-propyl ester —— C20H22ClN3O2S
    3-chloro-benzo[<i>b</i>]pyrido[2,3-<i>e</i>][1,4]thiazine-10-carboxylic acid 3-piperidin-1-yl-propyl ester
    —— di<(E)-2-octenyl> sulfide —— C16H30S
    di<(E)-2-octenyl> sulfide
    —— 2-morpholin-4-ylethyl 2-(4-cyclopropanecarboxamidophenylsulfanyl)-5-amino-6-(5-methylpyrazol-3-ylamino)-4-pyrimidinecarboxylate —— C25H30N8O4S
    2-morpholin-4-ylethyl 2-(4-cyclopropanecarboxamidophenylsulfanyl)-5-amino-6-(5-methylpyrazol-3-ylamino)-4-pyrimidinecarboxylate
    —— 1-(2,3,4,5,6-pentafluorophenylthio)-2-methoxynaphthalene —— C17H9F5OS
    1-(2,3,4,5,6-pentafluorophenylthio)-2-methoxynaphthalene
    —— 6-(4-chlorophenylamino)-3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hydrochloride —— C11H10ClN5S*ClH
    6-(4-chlorophenylamino)-3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hydrochloride
    —— 3-(4-pentenyl)-4-(phenylthio)-3-sulfolene —— C15H18O2S2
    3-(4-pentenyl)-4-(phenylthio)-3-sulfolene
    —— 2,3-dihydrobenzo[1,4]dithiin-7-amine —— C8H9NS2
    2,3-dihydrobenzo[1,4]dithiin-7-amine
    —— 2,3-dihydrobenzo[1,4]oxthiin-7-amine —— C8H9NOS
    2,3-dihydrobenzo[1,4]oxthiin-7-amine
    —— 3-(tert-butyldimethylsilyl)oxy-1-propyl trifluoromethyl sulfone —— C10H21F3O3SSi
    3-(tert-butyldimethylsilyl)oxy-1-propyl trifluoromethyl sulfone
    —— 2-(2-methylbenzyl)-4-(methylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile —— C14H13N3OS
    2-(2-methylbenzyl)-4-(methylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile
    —— tert-butyl 4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)-sulfanyl]purin-9-yl]ethyl]piperidine-1-carboxylate —— C24H29BrN6O4S
    tert-butyl 4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)-sulfanyl]purin-9-yl]ethyl]piperidine-1-carboxylate
    —— 2-(2-fluorobenzyl)-4-(methylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile —— C13H10FN3OS
    2-(2-fluorobenzyl)-4-(methylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile
    —— 1-(2-(hept-6-enyl)-1,3-dithian-2-yl)-3-(2-(hex-5-enyl)-1,3-dithian-2-yl)propane —— C24H42S4
    1-(2-(hept-6-enyl)-1,3-dithian-2-yl)-3-(2-(hex-5-enyl)-1,3-dithian-2-yl)propane
    —— 1-(2-(hex-5-enyl)-1,3-dithian-2-yl)-3-(1,3-dithian-2-yl)propane —— C17H30S4
    1-(2-(hex-5-enyl)-1,3-dithian-2-yl)-3-(1,3-dithian-2-yl)propane
    —— (E)-4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2-methylbutenoic acid —— C21H24N4O2S
    (E)-4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2-methylbutenoic acid
    —— 4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2,2-dimethylbutanoic acid —— C22H28N4O2S
    4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2,2-dimethylbutanoic acid
    —— 4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoic acid —— C22H28N4O2S
    4-[1-[2-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)ethyl]piperidin-4-yl]-2-methylbutanoic acid
    —— 4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2-methylbutanoic acid —— C21H26N4O2S
    4-[1-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-2-methylbutanoic acid
    —— 4-(difluoromethylsulfanyl)-1-fluoro-2-methyl-benzene —— C8H7F3S
    4-(difluoromethylsulfanyl)-1-fluoro-2-methyl-benzene
    —— ethyl (2Z)-3-[4-amino-2-(benzylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinyl]-2-(hydroxyimino)-propanoate —— C16H18N4O4S
    ethyl (2Z)-3-[4-amino-2-(benzylsulfanyl)-6-oxo-1,6-dihydro-5-pyrimidinyl]-2-(hydroxyimino)-propanoate
    —— 2-(methylthio)-3-methyl-5-benzyl-6-aminouracil —— C13H15N3OS
    2-(methylthio)-3-methyl-5-benzyl-6-aminouracil
    —— 5-(thien-3-yl)methoxy-3-methylthio-1,2,4-thiadiazole —— C8H8N2OS3
    5-(thien-3-yl)methoxy-3-methylthio-1,2,4-thiadiazole
    —— 6-amino-3-carbamoyl-2-carbethoxymethylthio-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine —— C16H22N4O3S
    6-amino-3-carbamoyl-2-carbethoxymethylthio-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine