3-nitro-2-(2-(trifluoromethyl)phenyl)-2H-chromene | 1175542-10-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-nitro-2-(2-(trifluoromethyl)phenyl)-2H-chromene
• CAS: 1175542-10-5
• 化学式: C₁₆H₁₀F₃NO₃
• 分子量: 321.256
• InChiKey: VALGDPUJVPIKLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-nitro-2-(2-(trifluoromethyl)phenyl)-2H-chromene 在 sodium azide 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以60%的产率得到4-(2-(trifluoromethyl)phenyl)-1,4-dihydrochromeno[4,3-d][1,2,3]triazole
  参考文献：
  名称：

  Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: a facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives

  摘要：

  1,3-Dipolar cycloaddition of 3-nitrochromen with sodium azide under catalyst-free conditions afforded 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives at 80 degrees C in DMSO is described. The generality of this reaction was demonstrated by synthesizing an array of 4-aryl-1,4-dihydrochromeno[4,3d][1,2,3]triazole derivatives. Clean reaction conditions, easy isolation, and good yields of the triazoles are the salient features of the methodology. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.002
• 作为产物：
  描述：

  2-trifluoromethyl-β-nitrostyrene 、 水杨醛 在 三乙烯二胺 作用下， 生成 3-nitro-2-(2-(trifluoromethyl)phenyl)-2H-chromene
  参考文献：
  名称：

  Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: a facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives

  摘要：

  1,3-Dipolar cycloaddition of 3-nitrochromen with sodium azide under catalyst-free conditions afforded 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives at 80 degrees C in DMSO is described. The generality of this reaction was demonstrated by synthesizing an array of 4-aryl-1,4-dihydrochromeno[4,3d][1,2,3]triazole derivatives. Clean reaction conditions, easy isolation, and good yields of the triazoles are the salient features of the methodology. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.002

文献信息

• “On-Water”-Promoted<i>C</i>-Alkylation of Indoles with 2-Aryl-3-nitro-2<i>H</i>-chromenes under Catalyst-Free Conditions
  作者：Pateliya Mujjamil Habib、Veerababurao Kavala、B. Rama Raju、Chun-Wei Kuo、Wen-Chang Huang、Ching-Fa Yao

  DOI：10.1002/ejoc.200900207

  日期：2009.9

  An environmentally benign method for the synthesis of indolyl(nitro)chromans from indoles and 2-aryl-3-nitro-2Hchromenes under catalyst-free conditions by use of an “onwater” concept is described. The salient features of the methodology are its clean reaction conditions, the eco-friendly

  描述了一种在无催化剂条件下通过使用“水上”概念从吲哚和 2-芳基-3-硝基-2Hchromenes 合成吲哚基（硝基）色满的环境友好方法。该方法的显着特点是其清洁的反应条件、环境友好的