嘧啶类化合物
嘧啶类化合物是一类分子结构中含有两个氮原子的六元杂环化合物，与哒嗪和吡嗪互为同分异构体。由于其分子中存在共轭双键，表现出独特的紫外光谱特性。这类化合物易溶于水，碱性较弱，并且不易发生亲电取代反应；仅在5-位可以进行溴化反应，而不具备硝化或磺化的能力，但容易经历亲核取代反应。
嘧啶及其衍生物广泛存在于自然界中，如磺胺嘧啶、巴比妥酸以及维生素B1等。在核酸分子内，有三种重要的嘧啶类碱基：尿嘧啶、胸腺嘧啶和胞嘧啶；其中，在DNA中主要包含胞嘧啶与胸腺嘧啶，而在RNA中则主要含有胞嘧啶及尿嘧啶，并且在某些特定的核酸中还可能发现少量的嘧啶修饰碱基。此外，许多药物分子如磺胺嘧啶、甲氧苄氨嘧啶和6-巯基嘌呤等都含有嘧啶环。
作为重要的医药原料，嘧啶及其衍生物被用于生产多种药物，例如维生素B1、磺胺嘧啶、磺胺异二甲嘧啶及磺胺间二甲氧嘧啶等。同时，它们也是农药的重要组成部分，包括二嗪农、嘧啶醇、灭瘟素、除草定、喃啶草、鼠立死、环菌灵、甲菌定、乙菌定、磺嘧菌灵、比嗪农、抗蚜威、乙基虫螨磷、虫螨磷、多氧霉素等。此外，作为染料的原料，具有三卤化嘧啶核结构的化合物因其与纤维之间的良好反应性，已成为一种备受关注的反应染料。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 6-amino-2-mercapto-3H-pyrimidin-4-one monohydrate | 65802-56-4 | C4H7N3O2S |
|
| —— | cis-1-Methyl-2-<2-(2-thienyl)vinyl)>-Δ<sup>2</sup>-tetrahydropyrimidin-tartrat | 21573-92-2 | C4H6O6*C11H14N2S |
|
| —— | 4-(4-bromo-1H-pyrazol-1-yl)benzoic acid | 926212-84-2 | C10H7BrN2O2 |
|
| —— | 4-Methylpyrimidine-2-thiol HCl | 6959-66-6 | C5H6ClN2S- |
|
| —— | Pyrimidine-4,6-diammonium hydrogen sulphate (1:2) | 77709-02-5 | C4H8N4O |
|
| —— | 4,6-Diamino-2-chlor-pyrimidin | 53557-61-2 | C4H5ClN4 |
|
| —— | [(3aR,4R,6Z,9R,10Z,11aR)-9-acetyloxy-6,10-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-(hydroxymethyl)but-2-enoate | 64439-43-6 | C22H28O8 |
|
| —— | 2-(4-chlorophenyl)pyrimidine-5-carboxylic acid | 878691-37-3 | C11H7ClN2O2 |
|
| —— | 4,6-dichloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine | 21254-22-8 | C8H8Cl2N4 |
|
| —— | 5,7-dichloro-2-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine | 1232223-43-6 | C11H6Cl2N4 |
|
| —— | 2-methyl-4-hydroxy-5,6-dichloropyrimidine | 32265-50-2 | C5H4Cl2N2O |
|
| —— | 2-chloro-5-nitropyrimidine-4,6-diamine | 408352-74-9 | C4H4ClN5O2 |
|
| —— | 5-bromo-4-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine | 717900-59-9 | C11H11BrClN3 |
|
| —— | Pyrimidin-4-ylamine trihydrochloride | 174500-31-3 | C4H8Cl3N3 |
|
| —— | 5-Bromo-2-isobutylthiopyrimidine | 1242336-74-8 | C8H11BrN2S |
|
| —— | 5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester | 147126-75-8 | C18H26FN3O4S |
|
| —— | 4,6-dichloro-5-propylpyrimidine | 63797-51-3 | C7H8Cl2N2 |
|
| —— | 2-(3-(Pyrimidin-2-yl)phenyl)ethylamine | 910404-93-2 | C12H13N3 |
|
| —— | 5-chloro-2-(piperidin-4-yl)pyrimidine | 944903-10-0 | C9H12ClN3 |
|
| —— | (4-chloropyrimidin-2-yl)methanol | 1093880-89-7 | C5H5ClN2O |
|
| —— | 4-Amino-N-methoxy-N-methyl-2-(methylthio)pyrimidine-5-carboxamide | 741714-02-3 | C8H12N4O2S |
|
| —— | (2-Morpholinopyrimidin-5-yl)methanol | 937796-13-9 | C9H13N3O2 |
|
| —— | Sulfameter sodium | 18179-67-4 | C11H11N4NaO3S |
|
| —— | 4-(3-hydroxypropylamino)-1,3-dimethyl-4H-pyrimidin-2-one | 34654-80-3 | C9H17N3O2 |
|
| —— | 5-Propyl-2-pyrimidinamine | 39268-72-9 | C7H11N3 |
|
| —— | 2-(3-Bromophenyl)pyrimidine-5-carbaldehyde | 1086393-72-7 | C11H7BrN2O |
|
| —— | 5-bromo-N-propylpyrimidin-2-amine | 1187385-92-7 | C7H10BrN3 |
|
| —— | Hydron;pyrimidin-4-amine;chloride | 174500-31-3 | C4H6ClN3 |
|
| —— | [(1R,2R,5S)-5-methyl-2-propan-2-ylcyclohexyl] (2S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-1,3-oxathiolane-2-carboxylate | 147027-10-9 | C18H27N3O4S |
|
| —— | 2-(Pyrimidin-5-yl)ethanamine | 856973-36-9 | C6H9N3 |
|
| —— | 4-bromomethyl-3-chloro-benzamide | 3932-97-6 | C8H7BrClNO |
|
| —— | methyl 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrole[2,3-d]pyrimidin-5-yl)ethyl]benzoate | 155405-80-4 | C16H16N4O3 |
|
| —— | 1-hydroxymethyl-1-phenylcyclopentane | 59115-90-1 | C12H16O |
|
| —— | pyrimidine 1,3-dioxide | 56642-54-7 | C4H4N2O2 |
|
| —— | ethyl 7-oxo-4H-pyrazolo[1,5-a]pyrimidine-6-carboxylate | 29274-18-8 | C9H9N3O3 |
|
| —— | Ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate | 43024-61-9 | C9H9N3O3 |
|
| —— | 5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-OL | 16082-26-1 | C7H7N3O |
|
| —— | 4,5-dichloro-1H-indole-2-carboxylic acid | 231295-84-4 | C9H5Cl2NO2 |
|
| —— | 3-(5-hydroxypyrimidin-2-yl)benzoic acid | 1092568-86-9 | C11H8N2O3 |
|
| —— | ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate | 1260543-99-4 | C12H17N3O4 |
|
| —— | (2,2-diphenyltetrahydrofuran-3-yl)methanol | 93651-75-3 | C17H18O2 |
|
| —— | 5-fluorobarbituric acid | 767-80-6 | C4H3FN2O3 |
|
| —— | 5-(trifluoromethyl)-1H-pyrimidine-2,4-di(17O2)one | 54-20-6 | C5H3F3N2O2 |
|
| —— | 6-bromo[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid | 300361-78-8 | C6H3BrN4O2 |
|
| —— | 2,6-dichloropyrimidin-4(3H)-one | 120977-94-8 | C4H2Cl2N2O |
|
| —— | (R)-5-benzyl-2,2,3-trimethylimidazolidin-4-one | 685128-77-2 | C13H18N2O |
|
| —— | 4-chloro-2-methyl-2H-pyrazolo[3,4-d]pyrimidine | 959430-67-2 | C6H5ClN4 |
|
| —— | methyl pyrrolo<3,2-e>indole-2-carboxylate | 107474-65-7 | C12H10N2O2 |
|
| —— | bis[4-(acryloyloxyethyl)thiophenyl]sulfide | 133811-67-3 | C22H22O4S3 |
|
| —— | 4-chromanol | 120523-16-2 | C9H10O2 |
|
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