嘧啶类化合物
嘧啶类化合物是一类分子结构中含有两个氮原子的六元杂环化合物，与哒嗪和吡嗪互为同分异构体。由于其分子中存在共轭双键，表现出独特的紫外光谱特性。这类化合物易溶于水，碱性较弱，并且不易发生亲电取代反应；仅在5-位可以进行溴化反应，而不具备硝化或磺化的能力，但容易经历亲核取代反应。
嘧啶及其衍生物广泛存在于自然界中，如磺胺嘧啶、巴比妥酸以及维生素B1等。在核酸分子内，有三种重要的嘧啶类碱基：尿嘧啶、胸腺嘧啶和胞嘧啶；其中，在DNA中主要包含胞嘧啶与胸腺嘧啶，而在RNA中则主要含有胞嘧啶及尿嘧啶，并且在某些特定的核酸中还可能发现少量的嘧啶修饰碱基。此外，许多药物分子如磺胺嘧啶、甲氧苄氨嘧啶和6-巯基嘌呤等都含有嘧啶环。
作为重要的医药原料，嘧啶及其衍生物被用于生产多种药物，例如维生素B1、磺胺嘧啶、磺胺异二甲嘧啶及磺胺间二甲氧嘧啶等。同时，它们也是农药的重要组成部分，包括二嗪农、嘧啶醇、灭瘟素、除草定、喃啶草、鼠立死、环菌灵、甲菌定、乙菌定、磺嘧菌灵、比嗪农、抗蚜威、乙基虫螨磷、虫螨磷、多氧霉素等。此外，作为染料的原料，具有三卤化嘧啶核结构的化合物因其与纤维之间的良好反应性，已成为一种备受关注的反应染料。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 4-氯-N-环丙基-6-甲基-2-嘧啶胺 | (4-chloro-6-methyl-pyrimidin-2-yl)-cyclopropyl-amine | 5734-73-6 | C8H10ClN3 |
|
| 4-氯-N-环丙基-5-甲基-2-嘧啶胺 | 4-Chloro-N-cyclopropyl-5-methylpyrimidin-2-amine | 1289385-24-5 | C8H10ClN3 |
|
| 4-氯-N-环丙基-2-嘧啶胺 | 4-Chloro-N-cyclopropylpyrimidin-2-amine | 1044771-76-7 | C7H8ClN3 |
|
| 4-氯-N-乙基-6-甲基-2-嘧啶胺 | 4-chloro-N-ethyl-6-methylpyrimidin-2-amine | 5748-33-4 | C7H10ClN3 |
|
| 4-氯-N-乙基-5-甲基-2-嘧啶胺 | 4-chloro-N-ethyl-5-methylpyrimidin-2-amine | 1289387-57-0 | C7H10ClN3 |
|
| 4-氯-N-(4-哌啶基甲基)-2-嘧啶胺 | 4-Chloro-N-(piperidin-4-ylmethyl)pyrimidin-2-amine | 916791-16-7 | C10H15ClN4 |
|
| 4-氯-N-(2-嘧啶)丁酰胺 | 4-chloro-<i>N</i>-pyrimidin-2-yl-butyramide | 27179-31-3 | C8H10ClN3O |
|
| 4-氯-N-(1-甲基乙基)-2-嘧啶胺 | 4-chloro-N-isopropylpyrimidin-2-amine | 71406-60-5 | C7H10ClN3 |
|
| 4-氯-7H-吡咯并[2,3-d]嘧啶-5-甲酸乙酯 | ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate | 144927-57-1 | C9H8ClN3O2 |
|
| 4-氯-7H-吡咯并[2,3-D]嘧啶-6-甲酸 | 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid | 1016241-80-7 | C7H4ClN3O2 |
|
| 4-氯-7H-吡咯并[2,3-D]嘧啶-5-甲醛 | 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde | 908287-21-8 | C7H4ClN3O |
|
| 4-氯-7H-吡咯[2,3-D]嘧啶-5-甲腈 | 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 24391-41-1 | C7H3ClN4 |
|
| 4-氯-7-甲基吡咯并[2,3-D]嘧啶 | 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine | 7781-10-4 | C7H6ClN3 |
|
| 4-氯-7-氟-吡啶[4,3-D]嘧啶 | 4-Chloro-7-fluoropyrido[4,3-d]pyrimidine | 175357-95-6 | C7H3ClFN3 |
|
| 4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7H-吡咯并[2,3-d]嘧啶 | 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine | 941685-26-3 | C12H18ClN3OSi |
|
| 4-氯-6-苯基噻吩并[2,3-D]嘧啶 | 4-chloro-6-phenylthieno[2,3-d]pyrimidine | 35970-79-7 | C12H7ClN2S |
|
| 4-氯-6-苯基嘧啶 | 4-chloro-6-phenylpyrimidine | 3435-26-5 | C10H7ClN2 |
|
| 4-氯-6-肼基嘧啶 | 4-chloro-6-hydrazinopyrimidine | 5767-35-1 | C4H5ClN4 |
|
| 4-氯-6-碘噻吩并[3,2-D]嘧啶 | 4-chloro-6-iodothieno[3,2-d]pyrimidine | 225382-62-7 | C6H2ClIN2S |
|
| 4-氯-6-碘-7H-吡咯并[2,3-D]嘧啶 | 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine | 876343-10-1 | C6H3ClIN3 |
|
| 4-氯-6-甲硫基嘧啶[5,4-d]并嘧啶 | 8-chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine | 176637-10-8 | C7H5ClN4S |
|
| 4-氯-6-甲硫基嘧啶 | 4-chloro-6-(methylthio)pyrimidine | 89283-48-7 | C5H5ClN2S |
|
| 4-氯-6-甲烷磺酰基-2-甲基-嘧啶 | 4-chloro-2-methyl-6-(methylsulfanyl)pyrimidine | 867131-59-7 | C6H7ClN2S |
|
| 4-氯-6-甲氧基嘧啶 | 4-chloro-6-methoxy-pyrimidine | 26452-81-3 | C5H5ClN2O |
|
| 4-氯-6-甲氧基-2-甲磺酰基嘧啶 | 4-chloro-6-methoxy-2-(methylsulfonyl)pyrimidine | 89466-55-7 | C6H7ClN2O3S |
|
| 4-氯-6-甲氧基-2-甲基嘧啶-5-胺 | 5-amino-4-methoxy-6-chloro-2-methyl-pyrimidine | 88474-31-1 | C6H8ClN3O |
|
| 4-氯-6-甲氧基-2-甲基嘧啶 | 4-chloro-6-methoxy-2-methylpyrimidine | 89466-39-7 | C6H7ClN2O |
|
| 4-氯-6-甲氧基-2-(甲亚磺酰基)嘧啶 | 4-Chloro-6-methoxy-2-(methylsulfinyl)pyrimidine | 1289385-30-3 | C6H7ClN2O2S |
|
| 4-氯-6-甲基氨基嘧啶 | 6-chloro-N-methylpyrimidin-4-amine | 65766-32-7 | C5H6ClN3 |
|
| 4-氯-6-甲基噻吩[2,3-D]嘧啶 | 4-chloro-6-methylthieno<2,3-d>pyrimidine | 106691-21-8 | C7H5ClN2S |
|
| 4-氯-6-甲基嘧啶-5-甲酸乙酯 | ethyl 4-chloro-6-methylpyrimidine-5-carboxylate | 157981-60-7 | C8H9ClN2O2 |
|
| 4-氯-6-甲基嘧啶 | 4-methyl-6-chloropyrimidine | 3435-25-4 | C5H5ClN2 |
|
| 4-氯-6-甲基-7H-吡咯并[2,3-D]嘧啶 | 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | 35808-68-5 | C7H6ClN3 |
|
| 4-氯-6-甲基-2-苯基嘧啶 | 4-chloro-6-methyl-2-phenyl-pyrimidine | 29509-92-0 | C11H9ClN2 |
|
| 4-氯-6-甲基-2-甲胺基嘧啶 | 4-chloro-N,6-dimethylpyrimidin-2-amine | 5738-15-8 | C6H8ClN3 |
|
| 4-氯-6-甲基-2-(甲基磺酰基)嘧啶 | 4-chloro-6-methyl-2-(methylsulfonyl)pyrimidine | 55329-22-1 | C6H7ClN2O2S |
|
| 4-氯-6-环己基氨基嘧啶 | 4-chloro-6-cyclohexylaminopyrimidine | 61667-11-6 | C10H14ClN3 |
|
| 4-氯-6-环丙基氨基嘧啶 | 6-chloro-N-cyclopropylpyrimidin-4-amine | 941294-43-5 | C7H8ClN3 |
|
| 4-氯-6-氯甲基嘧啶 | 4-chloro-6-(chloromethyl)pyrimidine | 85878-84-8 | C5H4Cl2N2 |
|
| 4-氯-6-氟嘧啶 | 4-chloro-6-fluoropyrimidine | 51422-01-6 | C4H2ClFN2 |
|
| 4-氯-6-戊基氨基嘧啶 | 6-Chloro-N-pentylpyrimidin-4-amine | 941294-44-6 | C9H14ClN3 |
|
| 4-氯-6-异丙氧基-嘧啶 | 4-chloro-6-isopropoxypyrimidine | 83774-13-4 | C7H9ClN2O |
|
| 4-氯-6-哌啶-5-嘧啶甲醛 | 4-chloro-6-piperidin-1-yl-pyrimidine-5-carbaldehyde | 54503-93-4 | C10H12ClN3O |
|
| 4-氯-6-吗啉-5-嘧啶甲醛 | 4-chloro-6-morpholin-4-yl-pyrimidine-5-carbaldehyde | 54503-94-5 | C9H10ClN3O2 |
|
| 4-氯-6-吗啉-4-基嘧啶-2-胺 | 4-chloro-6-morpholinopyrimidin-2-amine | 339016-18-1 | C8H11ClN4O |
|
| 4-氯-6-二甲氨基嘧啶 | 6-chloro-N,N-dimethylpyrimidin-4-amine | 31058-83-0 | C6H8ClN3 |
|
| 4-氯-6-乙氧基嘧啶-2-胺 | 4-ethoxy-6-chloro-pyrimidin-2-ylamine | 89784-02-1 | C6H8ClN3O |
|
| 4-氯-6-乙氧基嘧啶 | 4-chloro-6-ethoxypyrimidine | 28824-78-4 | C6H7ClN2O |
|
| 4-氯-6-乙氧基-2-甲硫基嘧啶 | 4-chloro-6-ethoxy-2-(methylthio)pyrimidine | 221679-84-1 | C7H9ClN2OS |
|
| 4-氯-6-乙氧基-2-(甲磺酰基)嘧啶 | 4-chloro-6-ethoxy-2-(methylsulfonyl)pyrimidine | 142596-33-6 | C7H9ClN2O3S |
|
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