嘧啶类化合物
嘧啶类化合物是一类分子结构中含有两个氮原子的六元杂环化合物，与哒嗪和吡嗪互为同分异构体。由于其分子中存在共轭双键，表现出独特的紫外光谱特性。这类化合物易溶于水，碱性较弱，并且不易发生亲电取代反应；仅在5-位可以进行溴化反应，而不具备硝化或磺化的能力，但容易经历亲核取代反应。
嘧啶及其衍生物广泛存在于自然界中，如磺胺嘧啶、巴比妥酸以及维生素B1等。在核酸分子内，有三种重要的嘧啶类碱基：尿嘧啶、胸腺嘧啶和胞嘧啶；其中，在DNA中主要包含胞嘧啶与胸腺嘧啶，而在RNA中则主要含有胞嘧啶及尿嘧啶，并且在某些特定的核酸中还可能发现少量的嘧啶修饰碱基。此外，许多药物分子如磺胺嘧啶、甲氧苄氨嘧啶和6-巯基嘌呤等都含有嘧啶环。
作为重要的医药原料，嘧啶及其衍生物被用于生产多种药物，例如维生素B1、磺胺嘧啶、磺胺异二甲嘧啶及磺胺间二甲氧嘧啶等。同时，它们也是农药的重要组成部分，包括二嗪农、嘧啶醇、灭瘟素、除草定、喃啶草、鼠立死、环菌灵、甲菌定、乙菌定、磺嘧菌灵、比嗪农、抗蚜威、乙基虫螨磷、虫螨磷、多氧霉素等。此外，作为染料的原料，具有三卤化嘧啶核结构的化合物因其与纤维之间的良好反应性，已成为一种备受关注的反应染料。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 5-溴-4-(4-乙苯基)嘧啶 | 5-Bromo-4-(4-ethylphenyl)pyrimidine | 951884-40-5 | C12H11BrN2 |
|
| 5-溴-4-(3-甲氧基苯基)嘧啶 | 5-Bromo-4-(3-methoxyphenyl)pyrimidine | 941294-40-2 | C11H9BrN2O |
|
| 5-溴-4-(3,4-二甲基苯基)嘧啶 | 5-Bromo-4-(3,4-dimethylphenyl)pyrimidine | 941294-38-8 | C12H11BrN2 |
|
| 5-溴-4-(2,5-二甲基苯基)嘧啶 | 5-Bromo-4-(2,5-dimethylphenyl)pyrimidine | 941294-35-5 | C12H11BrN2 |
|
| 5-溴-4-(2,4-二甲基苯基)嘧啶 | 5-Bromo-4-(2,4-dimethylphenyl)pyrimidine | 941294-39-9 | C12H11BrN2 |
|
| 5-溴-4,6-二甲氧基嘧啶 | 5-bromo-4,6-dimethoxypyrimidine | 4319-77-1 | C6H7BrN2O2 |
|
| 5-溴-4,6-二甲基嘧啶 | 5-bromo-4,6-dimethylpyrimidine | 157335-97-2 | C6H7BrN2 |
|
| 5-溴-4,6-二氟嘧啶 | 5-bromo-4,6-difluoropyrimidine | 946681-88-5 | C4HBrF2N2 |
|
| 5-溴-3-碘-1H-吡唑并[3,4-B]嘧啶 | 5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine | 875781-18-3 | C6H3BrIN3 |
|
| 5-溴-3,6-二甲基尿嘧啶 | 5-bromo-3,6-dimethylpyrimidine-2,4(1H,3H)-dione | 39968-37-1 | C6H7BrN2O2 |
|
| 5-溴-2-（2-甲氧基-4-甲基苯氧基）嘧啶 | 5-Bromo-2-(2-methoxy-4-methylphenoxy)pyrimidine | 1017789-03-5 | C12H11BrN2O2 |
|
| 5-溴-2-苯氧基嘧啶 | 5-bromo-2-phenoxypyrimidine | 257280-25-4 | C10H7BrN2O |
|
| 5-溴-2-苯基嘧啶-4-羧酸 | 5-bromo-2-phenyl-pyrimidine-4-carboxylic acid | 179260-95-8 | C11H7BrN2O2 |
|
| 5-溴-2-苯基嘧啶 | 5-bromo-2-phenylpyrimidine | 38696-20-7 | C10H7BrN2 |
|
| 5-溴-2-苯基-4(3H)-嘧啶酮 | 5-bromo-2-phenyl-3H-pyrimidin-4-one | 26786-28-7 | C10H7BrN2O |
|
| 5-溴-2-肼基嘧啶 | 5-bromo-2-hydrazinopyrimidine | 823-89-2 | C4H5BrN4 |
|
| 5-溴-2-羟基嘧啶-4-甲酸甲酯 | 4-Methoxycarbonyl-5-brompyrimidin-2-on | 71933-03-4 | C6H5BrN2O3 |
|
| 5-溴-2-羟基嘧啶 | 5-bromopyrimidin-2-ol | 38353-06-9 | C4H3BrN2O |
|
| 5-溴-2-羟基-4-甲基嘧啶 | 5-bromo-4-methyl-1<i>H</i>-pyrimidin-2-one | 69849-34-9 | C5H5BrN2O |
|
| 5-溴-2-碘嘧啶 | 5-bromo-2-iodopyrimidine | 183438-24-6 | C4H2BrIN2 |
|
| 5-溴-2-甲磺酰基嘧啶 | 5-bromo-2-(methylsulfonyl)pyrimidine | 38275-48-8 | C5H5BrN2O2S |
|
| 5-溴-2-甲氧基嘧啶 | 5-bromo-2-methoxypyrimidine | 14001-66-2 | C5H5BrN2O |
|
| 5-溴-2-甲巯基嘧啶 | 5-bromo-2-methylthiopyrimidine | 14001-67-3 | C5H5BrN2S |
|
| 5-溴-2-甲基氨基嘧啶 | 5-bromo-N-methylpyrimidin-2-amine | 31402-54-7 | C5H6BrN3 |
|
| 5-溴-2-甲基嘧啶-4-甲酸乙酯 | ethyl 5-bromo-2-methyl-4-pyrimidinecarboxylate | 83410-38-2 | C8H9BrN2O2 |
|
| 5-溴-2-甲基-4(1H)-嘧啶酮 | 5-bromo-2-methyl-4(3H)-pyrimidinone | 1676-57-9 | C5H5BrN2O |
|
| 5-溴-2-环己基氨基嘧啶 | 5-bromo-N-cyclohexylpyrimidin-2-amine | 886366-17-2 | C10H14BrN3 |
|
| 5-溴-2-环丙基氨基嘧啶 | 5-bromo-N-cyclopropylpyrimidin-2-amine | 886366-20-7 | C7H8BrN3 |
|
| 5-溴-2-环丙基嘧啶 | 5-bromo-2-cyclopropylpyrimidine | 304902-96-3 | C7H7BrN2 |
|
| 5-溴-2-氰基嘧啶 | 5-bromopyrimidine-2-carbonitrile | 38275-57-9 | C5H2BrN3 |
|
| 5-溴-2-氯嘧啶-4-羧酸 | 5-Bromo-2-chloropyrimidine-4-carboxylic acid | 933739-55-0 | C5H2BrClN2O2 |
|
| 5-溴-2-氯嘧啶 | 5-Bromo-2-chloropyrimidine | 32779-36-5 | C4H2BrClN2 |
|
| 5-溴-2-氯-N,N-二甲基嘧啶-4-胺 | (5-bromo-2-chloro-pyrimidin-4-yl)-dimethyl-amine | 57054-86-1 | C6H7BrClN3 |
|
| 5-溴-2-氯-7H-吡咯并[2,3-D]嘧啶 | 5-bromo-2-chloro-7H-pyrrolo[2,3-d]pyrimidine | 1060816-58-1 | C6H3BrClN3 |
|
| 5-溴-2-氯-4-甲氧基嘧啶 | 5-bromo-2-chloro-4-methoxypyrimidine | 57054-92-9 | C5H4BrClN2O |
|
| 5-溴-2-氯-4-甲基嘧啶 | 5-bromo-2-chloro-4-methylpyrimidine | 633328-95-7 | C5H4BrClN2 |
|
| 5-溴-2-氯-4-吗啉嘧啶 | 5-Bromo-2-chloro-4-morpholinopyrimidine | 139502-01-5 | C8H9BrClN3O |
|
| 5-溴-2-氯-4-(苯基甲氧基)-嘧啶 | 2-chloro-4-benzyloxy-5-bromopyrimidine | 205672-19-1 | C11H8BrClN2O |
|
| 5-溴-2-氯-4-(甲硫基)嘧啶 | 5-bromo-2-chloro-4-(methylthio)pyrimidine | 59549-51-8 | C5H4BrClN2S |
|
| 5-溴-2-氯-4-(哌啶-1-基)嘧啶 | 5-bromo-2-chloro-4-(piperidin-1-yl)pyrimidine | 62880-67-5 | C9H11BrClN3 |
|
| 5-溴-2-氯-4-(三氟甲基)嘧啶 | 5-bromo-2-chloro-4-(trifluoromethyl)pyrimidine | 785777-92-6 | C5HBrClF3N2 |
|
| 5-溴-2-氯-4-(1-吡咯烷基)嘧啶 | 5-Bromo-2-chloro-4-(pyrrolidin-1-yl)pyrimidine | 57054-90-7 | C8H9BrClN3 |
|
| 5-溴-2-氯-4,6-二甲基嘧啶 | 2-Chloro-5-bromo-4,6-dimethyl-pyrimidine | 4786-72-5 | C6H6BrClN2 |
|
| 5-溴-2-氟嘧啶 | 5-bromo-2-fluoropyrimidine | 62802-38-4 | C4H2BrFN2 |
|
| 5-溴-2-异丙氧基嘧啶 | 5-bromo-2-isopropoxypyrimidine | 121487-12-5 | C7H9BrN2O |
|
| 5-溴-2-嘧啶甲酸甲酯 | methyl 5-bromopyrimidine-2-carboxylate | 89581-38-4 | C6H5BrN2O2 |
|
| 5-溴-2-嘧啶甲酸乙酯 | ethyl 5-bromopyrimidine-2-carboxylate | 1197193-30-8 | C7H7BrN2O2 |
|
| 5-溴-2-嘧啶甲酸乙酯 | ethyl 5-bromopicolinate | 77199-09-8 | C8H8BrNO2 |
|
| 5-溴-2-嘧啶甲胺 | (5-bromopyrimidin-2-yl)methylamine | 1240783-02-1 | C5H6BrN3 |
|
| 5-溴-2-嘧啶乙腈 | 2-(5-bromopyrimidin-2-yl)acetonitrile | 831203-15-7 | C6H4BrN3 |
|
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