嘧啶类化合物
嘧啶类化合物是一类分子结构中含有两个氮原子的六元杂环化合物，与哒嗪和吡嗪互为同分异构体。由于其分子中存在共轭双键，表现出独特的紫外光谱特性。这类化合物易溶于水，碱性较弱，并且不易发生亲电取代反应；仅在5-位可以进行溴化反应，而不具备硝化或磺化的能力，但容易经历亲核取代反应。
嘧啶及其衍生物广泛存在于自然界中，如磺胺嘧啶、巴比妥酸以及维生素B1等。在核酸分子内，有三种重要的嘧啶类碱基：尿嘧啶、胸腺嘧啶和胞嘧啶；其中，在DNA中主要包含胞嘧啶与胸腺嘧啶，而在RNA中则主要含有胞嘧啶及尿嘧啶，并且在某些特定的核酸中还可能发现少量的嘧啶修饰碱基。此外，许多药物分子如磺胺嘧啶、甲氧苄氨嘧啶和6-巯基嘌呤等都含有嘧啶环。
作为重要的医药原料，嘧啶及其衍生物被用于生产多种药物，例如维生素B1、磺胺嘧啶、磺胺异二甲嘧啶及磺胺间二甲氧嘧啶等。同时，它们也是农药的重要组成部分，包括二嗪农、嘧啶醇、灭瘟素、除草定、喃啶草、鼠立死、环菌灵、甲菌定、乙菌定、磺嘧菌灵、比嗪农、抗蚜威、乙基虫螨磷、虫螨磷、多氧霉素等。此外，作为染料的原料，具有三卤化嘧啶核结构的化合物因其与纤维之间的良好反应性，已成为一种备受关注的反应染料。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 4-氯-6-乙氧基-2-(甲亚磺酰基)嘧啶 | 4-Chloro-6-ethoxy-2-(methylsulfinyl)pyrimidine | 1289386-28-2 | C7H9ClN2O2S |
|
| 4-氯-6-乙基氨基嘧啶 | (6-chloro-pyrimidin-4-yl)ethylamine | 872511-30-3 | C6H8ClN3 |
|
| 4-氯-6-乙基噻吩并[2,3-d]嘧啶 | 4-chloro-6-ethylthieno<2,3-d>pyrimidine | 81136-42-7 | C8H7ClN2S |
|
| 4-氯-6-乙基嘧啶 | 4-chloro-6-ethylpyrimidine | 141602-25-7 | C6H7ClN2 |
|
| 4-氯-6-乙基-5-碘嘧啶 | 4-chloro-5-iodo-6-ethylpyrimidine | 141602-29-1 | C6H6ClIN2 |
|
| 4-氯-6-乙基-5-氟嘧啶 | 4-chloro-6-ethyl-5-fluoropyrimidine | 137234-74-3 | C6H6ClFN2 |
|
| 4-氯-6-乙基-2-甲基嘧啶 | 4-chloro-6-ethyl-2-methylpyrimidine | 89966-72-3 | C7H9ClN2 |
|
| 4-氯-6-丙基氨基嘧啶 | 6-Chloro-N-propylpyrimidin-4-amine | 941294-33-3 | C7H10ClN3 |
|
| 4-氯-6-三氟甲基嘧啶 | 4-chloro-6-(trifluoromethyl)pyrimidine | 37552-81-1 | C5H2ClF3N2 |
|
| 4-氯-6-(苯基甲氧基)-2-嘧啶胺 | 2-amino-4-(benzyloxy)-6-chloropyrimidine | 210992-85-1 | C11H10ClN3O |
|
| 4-氯-6-(甲氧基甲基)-2-苯基嘧啶 | 4-chloro-6-methoxymethyl-2-phenylpyrimidine | 325685-59-4 | C12H11ClN2O |
|
| 4-氯-6-(吡咯啉-1-基)嘧啶 | 4-chloro-6-(pyrrolidin-1-yl)pyrimidine | 939986-64-8 | C8H10ClN3 |
|
| 4-氯-6-(4-吗啉)-5-嘧啶胺 | 4-chloro-6-morpholin-4-yl-pyrimidin-5-ylamine | 84762-69-6 | C8H11ClN4O |
|
| 4-氯-6-(3-甲氧基丙基氨基)嘧啶 | 6-Chloro-N-(3-methoxypropyl)pyrimidin-4-amine | 941294-46-8 | C8H12ClN3O |
|
| 4-氯-6-(1H咪唑-1-基)嘧啶 | 4-chloro-6-(1H-imidazol-1-yl)pyrimidine | 114834-02-5 | C7H5ClN4 |
|
| 4-氯-6-(1H-吡唑-1-基)嘧啶 | 4-chloro-6-(1H-pyrazol-1-yl)pyrimidine | 114833-95-3 | C7H5ClN4 |
|
| 4-氯-6,7-二氢-5H-环戊并嘧啶 | 4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine | 83942-13-6 | C7H7ClN2 |
|
| 4-氯-5H-吡咯并[3,2-d]嘧啶-2-胺 | 4-chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine | 943736-58-1 | C6H5ClN4 |
|
| 4-氯-5-苯基噻酚[2,3-D]嘧啶 | 4-chloro-5-phenylthieno[2,3-d]pyrimidine | 182198-35-2 | C12H7ClN2S |
|
| 4-氯-5-碘嘧啶 | 4-chloro-5-iodopyrimidine | 63558-65-6 | C4H2ClIN2 |
|
| 4-氯-5-碘-7H-吡咯并[2,3-d]嘧啶 | 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine | 123148-78-7 | C6H3ClIN3 |
|
| 4-氯-5-碘-6-甲基嘧啶 | 4-chloro-5-iodo-6-methylpyrimidine | 83410-15-5 | C5H4ClIN2 |
|
| 4-氯-5-碘-2-甲基-嘧啶 | 2-methyl-4-chloro-5-iodopyrimidine | 111079-17-5 | C5H4ClIN2 |
|
| 4-氯-5-硝基嘧啶 | 4-chloro-5-nitropyrimidine | 150943-50-3 | C4H2ClN3O2 |
|
| 4-氯-5-甲氧基嘧啶-2-胺 | 4-chloro-5-methoxypyrimidin-2-amine | 4763-36-4 | C5H6ClN3O |
|
| 4-氯-5-甲氧基嘧啶 | 4-chloro-5-methoxy-pyrimidine | 695-85-2 | C5H5ClN2O |
|
| 4-氯-5-甲基噻吩并[2,3-d]嘧啶-6-羧酸甲酯 | methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | 832113-96-9 | C9H7ClN2O2S |
|
| 4-氯-5-甲基噻吩并[2,3-d]嘧啶 | 4-chloro-5-methylthieno[2,3-d]pyrimidine | 43088-67-1 | C7H5ClN2S |
|
| 4-氯-5-甲基嘧啶-2-胺 | 4-chloro-5-methylpyrimidin-2-yl-amine | 20090-58-8 | C5H6ClN3 |
|
| 4-氯-5-甲基嘧啶 | 4-chloro-5-methylpyrimidine | 51957-32-5 | C5H5ClN2 |
|
| 4-氯-5-甲基-7H-吡咯并[2,3-d]嘧啶 | 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine | 1618-36-6 | C7H6ClN3 |
|
| 4-氯-5-甲基-6-苯基噻吩[2,3-D]嘧啶 | 4-chloro-5-methyl-6-phenylthieno[2,3-d]pyrimidine | 306934-78-1 | C13H9ClN2S |
|
| 4-氯-5-甲基-2-(甲磺酰基)嘧啶 | 4-chloro-5-methyl-2-(methylsulfonyl)pyrimidine | 325780-94-7 | C6H7ClN2O2S |
|
| 4-氯-5-甲基-2-(甲基硫代)嘧啶 | 4-chloro-5-methyl-2-(methylthio)pyrimidine | 61044-96-0 | C6H7ClN2S |
|
| 4-氯-5-溴嘧啶 | 5-bromo-4-chloropyrimidine | 56181-39-6 | C4H2BrClN2 |
|
| 4-氯-5-溴-2-甲磺酰基嘧啶 | 5-bromo-4-chloro-2-(methylsulfonyl)pyrimidine | 79091-24-0 | C5H4BrClN2O2S |
|
| 4-氯-5-氨基-6-肼基嘧啶 | 4-chloro-6-hydrazinylpyrimidin-5-amine | 42786-59-4 | C4H6ClN5 |
|
| 4-氯-5-氟嘧啶-2-胺 | 4-chloro-5-fluoropyrimidin-2-amine | 1683-75-6 | C4H3ClFN3 |
|
| 4-氯-5-氟嘧啶 | 4-chloro-5-fluoropyrimidine | 347418-42-2 | C4H2ClFN2 |
|
| 4-氯-5-氟-7H-吡咯并[2,3-D]-嘧啶 | 4-chloro-7-fluoro-7-deazapurine | 582313-57-3 | C6H3ClFN3 |
|
| 4-氯-5-氟-6-乙烯基嘧啶 | 4-chloro-5-fluoro-6-vinylpyrimidine | 1403893-61-7 | C6H4ClFN2 |
|
| 4-氯-5-氟-2-甲基嘧啶 | 4-chloro-5-fluoro-2-methylpyrimidine | 898044-50-3 | C5H4ClFN2 |
|
| 4-氯-5-异丙基嘧啶 | 4-Chloro-5-isopropylpyrimidine | 1015846-32-8 | C7H9ClN2 |
|
| 4-氯-5-嘧啶甲醛 | 4-Chloropyrimidine-5-carbaldehyde | 933703-03-8 | C5H3ClN2O |
|
| 4-氯-5-嘧啶乙酸乙酯 | ethyl 2-(4-chloropyrimidin-5-yl)acetate | 6214-47-7 | C8H9ClN2O2 |
|
| 4-氯-5-乙基嘧啶 | 4-chloro-5-ethylpyrimidine | 54128-01-7 | C6H7ClN2 |
|
| 4-氯-5,7-二氢噻吩并[3,4-d]嘧啶 | 4-chloro-5,7-dihydrothieno[3,4-d]pyrimidine | 53826-89-4 | C6H5ClN2S |
|
| 4-氯-5,7-二氢-6H-吡咯并[2,3-D]嘧啶-6-酮 | 4-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one | 346599-63-1 | C6H4ClN3O |
|
| 4-氯-5,7-二氢-2-甲基-噻吩并[3,4-D]嘧啶 | 4-chloro-2-methyl-5,7-dihydrothieno<3,4-d>pyrimidine | 5719-46-0 | C7H7ClN2S |
|
| 4-氯-5,6-二甲基噻吩[2,3-D]嘧啶 | 4-chloro-5,6-dimethylthieno[2,3-d]pyrimidine | 108831-68-1 | C8H7ClN2S |
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