嘧啶类化合物
嘧啶类化合物是一类分子结构中含有两个氮原子的六元杂环化合物，与哒嗪和吡嗪互为同分异构体。由于其分子中存在共轭双键，表现出独特的紫外光谱特性。这类化合物易溶于水，碱性较弱，并且不易发生亲电取代反应；仅在5-位可以进行溴化反应，而不具备硝化或磺化的能力，但容易经历亲核取代反应。
嘧啶及其衍生物广泛存在于自然界中，如磺胺嘧啶、巴比妥酸以及维生素B1等。在核酸分子内，有三种重要的嘧啶类碱基：尿嘧啶、胸腺嘧啶和胞嘧啶；其中，在DNA中主要包含胞嘧啶与胸腺嘧啶，而在RNA中则主要含有胞嘧啶及尿嘧啶，并且在某些特定的核酸中还可能发现少量的嘧啶修饰碱基。此外，许多药物分子如磺胺嘧啶、甲氧苄氨嘧啶和6-巯基嘌呤等都含有嘧啶环。
作为重要的医药原料，嘧啶及其衍生物被用于生产多种药物，例如维生素B1、磺胺嘧啶、磺胺异二甲嘧啶及磺胺间二甲氧嘧啶等。同时，它们也是农药的重要组成部分，包括二嗪农、嘧啶醇、灭瘟素、除草定、喃啶草、鼠立死、环菌灵、甲菌定、乙菌定、磺嘧菌灵、比嗪农、抗蚜威、乙基虫螨磷、虫螨磷、多氧霉素等。此外，作为染料的原料，具有三卤化嘧啶核结构的化合物因其与纤维之间的良好反应性，已成为一种备受关注的反应染料。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 4-三氟甲基嘧啶-5-甲酸乙酯 | ethyl 4-trifluoromethylpyrimidine-5-carboxylate | 187035-81-0 | C8H7F3N2O2 |
|
| 4-三氟甲基嘧啶 | 4-(trifluoromethyl)pyrimidine | 136547-16-5 | C5H3F3N2 |
|
| 4-三氟甲基-5-溴嘧啶 | 5-bromo-4-(trifluoromethyl)pyrimidine | 785777-88-0 | C5H2BrF3N2 |
|
| 4-三氟甲基-2-甲硫基-嘧啶-5-甲酸 | 2-(Methylthio)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid | 149771-17-5 | C7H5F3N2O2S |
|
| 4-三氟甲基-2-甲基硫代嘧啶 | 2-(methylthio)-4-(trifluoromethyl)pyrimidine | 136547-20-1 | C6H5F3N2S |
|
| 4-三氟甲基-2-氨基嘧啶 | 2-amino-4-trifluoromethylpyrimidine | 16075-42-6 | C5H4F3N3 |
|
| 4-三丁基甲锡烷基-2-硫代甲基嘧啶 | 2-(methylthio)-4-(tributylstannyl)pyrimidine | 123061-49-4 | C17H32N2SSn |
|
| 4-[[(3-氯-4-甲氧基苯基)甲基]氨基]-2-[(2S)-2-羟甲基-1-吡咯烷基]-5-嘧啶羧酸乙酯 | (S)-ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate | 330785-83-6 | C20H25ClN4O4 |
|
| 4-[(5-溴嘧啶-2-基)硫代]苯胺 | 4-(5-bromopyrimidin-2-ylsulfanyl)phenylamine | 849035-61-6 | C10H8BrN3S |
|
| 4-[(5-溴-2-嘧啶基)氧基]苯胺 | 4-(5-bromo-2-pyrimidyloxy)aniline | 76660-37-2 | C10H8BrN3O |
|
| 4-[(4-羟基-2-嘧啶基)氨基]苯腈 | 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile | 189956-45-4 | C11H8N4O |
|
| 4-P-甲苯嘧啶-2-基胺 | 4-(p-tolyl)pyrimidin-2-amine | 263276-44-4 | C11H11N3 |
|
| 4-(苄氧基)-5-溴-N,N-二甲基嘧啶-2-胺 | 2-dimethylamino-4-benzyloxy-5-bromopyrimidine | 205672-20-4 | C13H14BrN3O |
|
| 4-(甲基硫代)嘧啶-2-胺 | 2-Amino-4-methylmercapto-pyrimidin | 1073-54-7 | C5H7N3S |
|
| 4-(甲基硫代)-1H-吡唑并[3,4-d]嘧啶 | 4-methylthio-1H-pyrazolo[3,4-d]pyrimidine | 5418-10-0 | C6H6N4S |
|
| 4-(溴甲基)嘧啶 | 4-(bromomethyl)pyrimidine | 54198-78-6 | C5H5BrN2 |
|
| 4-(溴甲基)-2,6-二氯嘧啶 | 4-(Bromomethyl)-2,6-dichloropyrimidine | 1289387-93-4 | C5H3BrCl2N2 |
|
| 4-(氯甲基)嘧啶盐酸盐 | 4-(Chloromethyl)pyrimidine hydrochloride | 135207-28-2 | C5H6Cl2N2 |
|
| 4-(氯甲基)嘧啶 | 4-(chloromethyl)pyrimidine | 54198-81-1 | C5H5ClN2 |
|
| 4-(氨基甲基)嘧啶盐酸盐 | 4-(aminomethyl)pyrimidine hydrochloride | 1138011-17-2 | C5H7N3*ClH |
|
| 4-(异噁唑-4-基)-2-(甲基硫代)嘧啶 | 2-(methylsulfanyl)-4-(1,2-oxazol-4-yl)pyrimidine | 956721-96-3 | C8H7N3OS |
|
| 4-(嘧啶-5-基)苯甲酸 | 4-[Pyrimidin-5-yl]-Benzoic Acid | 216959-91-0 | C11H8N2O2 |
|
| 4-(嘧啶-5-基)吗啉 | 4-(pyrimidin-5-yl)morpholine | 91233-71-5 | C8H11N3O |
|
| 4-(嘧啶-2-氧基)苯甲醛 | 4-(pyrimidinyloxy)benzenecarbaldehyde | 433920-92-4 | C11H8N2O2 |
|
| 4-(嘧啶-2-基)苯甲酸 | 4-(pyrimidin-2-yl)benzoic acid | 199678-12-1 | C11H8N2O2 |
|
| 4-(嘧啶-2-基)哌啶-4-醇 | 4-hydroxy-4-(2-pyrimidinyl)piperidine | 861217-38-1 | C9H13N3O |
|
| 4-(哌啶-4-基)嘧啶 | 4-(piperidin-4-yl)pyrimidine | 954220-47-4 | C9H13N3 |
|
| 4-(吡啶-4-基)嘧啶-2-醇 | 6-(pyridin-4-yl)pyrimidin-2(1H)-one | 208936-44-1 | C9H7N3O |
|
| 4-(吡啶-2基)-2-(三氟甲基)嘧啶 | 4-(Pyridin-2-yl)-2-(trifluoromethyl)pyrimidine | 1269293-96-0 | C10H6F3N3 |
|
| 4-(二甲氧甲基)嘧啶 | acetal dimethylique du pyrimidine-4 carboxaldehyde | 25746-87-6 | C7H10N2O2 |
|
| 4-(二甲氧甲基)-2-甲硫基嘧啶 | 4-dimethoxymethyl-2-methylsulfanylpyrimidine | 180869-36-7 | C8H12N2O2S |
|
| 4-(乙基硫代)嘧啶-2-胺 | 4-ethylsulfanyl-pyrimidin-2-ylamine | 6311-81-5 | C6H9N3S |
|
| 4-(丙-1-炔基)嘧啶-2-胺 | 4-(Prop-1-yn-1-yl)pyrimidin-2-amine | 1207175-48-1 | C7H7N3 |
|
| 4-(三氟甲基)嘧啶-5-羧酸 | 4-(trifluoromethyl)pyrimidine-5-carboxylic acid | 220880-12-6 | C6H3F3N2O2 |
|
| 4-(三氟甲基)-2-巯基嘧啶 | 4-(trifluoromethyl)pyrimidine-2-thiol | 136547-17-6 | C5H3F3N2S |
|
| 4-(6-氯嘧啶-4-基)吗啉 | 4-(6-chloropyrimidin-4-yl)morpholine | 22177-92-0 | C8H10ClN3O |
|
| 4-(6-氯-4-嘧啶)-哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate | 203519-88-4 | C13H19ClN4O2 |
|
| 4-(6-氯-2-甲基嘧啶)-吗啉 | 4-(6-chloro-2-methyl-pyrimidin-4-yl)-morpholine | 22177-99-7 | C9H12ClN3O |
|
| 4-(5-辛基-2-嘧啶基)苯基庚酸酯 | 1-heptanoyloxy-4-(5-octyl-pyrimidin-2-yl)-benzene | 58415-91-1 | C25H36N2O2 |
|
| 4-(5-碘-4-嘧啶)吗啉 | 4-(5-iodopyrimidin-4-yl)morpholine | 1356055-09-8 | C8H10IN3O |
|
| 4-(5-嘧啶基)苯甲醛 | 4-(pyrimidin-5-yl)benzaldehyde | 198084-12-7 | C11H8N2O |
|
| 4-(5-嘧啶基)丁醛 | 4-(5-pyrimidyl)butyraldehyde | 260441-11-0 | C8H10N2O |
|
| 4-(4-甲氧苯基)-6-三氟甲基嘧啶-2-胺 | 2-amino-4-(4-methoxyphenyl)-6-(trifluoromethyl)pyrimidine | 519056-51-0 | C12H10F3N3O |
|
| 4-(4-溴苯基)-2-甲基嘧啶 | 4-(4-Bromophenyl)-2-methylpyrimidine | 499785-50-1 | C11H9BrN2 |
|
| 4-(4-溴苯基)-2,6-二苯基嘧啶 | 4-(4-bromophenyl)-2,6-diphenylpyrimidine | 58536-46-2 | C22H15BrN2 |
|
| 4-(4-溴嘧啶-2-基)吗啉 | 4-(4-bromopyrimidin-2-yl)morpholine | 663194-10-3 | C8H10BrN3O |
|
| 4-(4-氯苯基)嘧啶-2-胺 | 4-(4-chlorophenyl)pyrimidin-2-amine | 133256-51-6 | C10H8ClN3 |
|
| 4-(4-氯苯基)嘧啶-2-硫醇 | 4-(4-chlorophenyl)-2-pyrimidinethiol | 175203-08-4 | C10H7ClN2S |
|
| 4-(4-氯嘧啶-2-基)吗啉 | 4-(4-chloropyrimidin-2-yl)morpholine | 24192-96-9 | C8H10ClN3O |
|
| 4-(4-氨基苯基)嘧啶 | 4-(pyrimidin-4-yl)aniline | 69491-58-3 | C10H9N3 |
|
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