毒理性
识别和使用：3-苯基丙醇是一种无色液体。它闻起来像风信子，尝起来类似于杏。它存在于许多水果和浆果、肉桂和一些类型的香脂中。3-苯基丙醇存在于烟草烟雾中。3-苯基丙醇通常用作香水，适用于抗汗剂、乳液、口红、滑石粉、片状肥皂、洗发水、护发素、沐浴/淋浴凝胶、洗衣粉、液体洗涤剂、织物软化剂、蜡烛、香。也用于花香组合物，以增添香脂和东方调。它在美国没有注册当前的杀虫剂使用，但批准的杀虫剂使用可能会定期更改，因此必须咨询联邦、州和地方当局以获取当前批准的使用。人类暴露和毒性：在一项多中心研究中，对218名已知有接触性皮炎的香料敏感患者进行了贴片测试。在5%的凡士林中观察到3-苯基丙醇在香料敏感患者中的反应（0.9%）。动物研究：在大鼠口服3-苯基丙醇剂量为1.31、2.56和5.0 g/kg/bw的剂量下，前两天内发生死亡。观察到的临床迹象是轻微的嗜睡和肌肉松弛。在一项急性口服毒性研究的初步筛选中，将含有50% 3-苯基-1-丙醇的玉米油溶液口服给10只大鼠，剂量为5 g/kg bw，其中九只（9/10）大鼠死亡。在另一项研究中，大鼠口服含有50% 3-苯基丙醇的玉米油溶液，剂量为1.47、2.15、3.16和4.64 g/kg bw。在1.47 g/kg时发生一次死亡；在2.15 g/kg和4.64 g/kg时也发生死亡。在研究期间观察到的临床迹象是抑郁、呼吸减慢、共济失调和毛发直立。尸检时的肉眼观察发现，在三个较低剂量下肺部出现暗红色区域，在最高剂量下肺部呈暗红色。在兔子的刺激性研究中，3-苯基丙醇以2.5和5 g/kg的剂量在闭合状态下应用24小时。在2.5 g/kg时，观察到中度的红斑和轻微到中度的水肿。在5 g/kg时，观察到中到重度的红斑和中等程度的水肿。在另一项兔子研究中，3-苯基-1-丙醇以5 g/kg的剂量在闭合状态下应用24小时。观察到中到重度的红斑、严重的水肿、脱屑和坏死。将0.5 mL的3-苯基丙醇应用于完整和磨损的皮肤24小时，在闭合状态下。观察到中等程度的刺激。还观察到坏死。在细菌和哺乳动物细胞线测试中没有发现致突变或遗传毒性活性。
IDENTIFICATION AND USE: 3-Phenylpropanol is a colorless liquid. It smells like hyacinths and tastes similar to apricot. It occurs in many fruits and berries, cinnamon and some types of balsam. 3-Phenylpropanol occurs in tobacco smoke. 3-Phenylpropanol is typically used as a perfume for applications such as antiperspirants, creams-lotions, lipsticks, talcum powder, tablet soap, shampoo, hair conditioner, bath/shower gel, detergent powder, liquid detergent, fabric softener, candles, incense. Also used in blossom compositions for balsamic and oriental notes. It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: In a multicenter study, 218 fragrance sensitive patients with proven contact dermatitis were patch tested. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenylpropanol at 5% in petrolatum. ANIMAL STUDIES: In rats dosed orally with 3-phenylpropanol at dose levels of 1.31, 2.56 and 5.0 g/kg/bw deaths occurred within the first 2 days. The clinical signs observed were slight lethargy and flaccid muscle tone. In a preliminary screen for an acute oral toxicity study, a 50% solution of 3-phenyl-1-propanol in corn oil was administered orally to 10 rats at a dose level of 5 g/kg bw, nine (9/10) rats died. In another study, rats were dosed orally with a 50% solution of 3-phenylpropanol in corn oil at dose levels of 1.47, 2.15, 3.16 and 4.64 g/ kg bw. One death occurred at 1.47 g/kg; and at 2.15 and at 4.64 g/kg. The clinical signs observed during the study were depression, hypopnea, ataxia and piloerection. Gross observations at necropsy revealed dark red areas in the lungs at the three lower doses and dark red lungs at the highest dose. In an irritation study in rabbits 3-phenylpropanol was applied for 24 hr under occlusion at dose levels of 2.5 and 5 g/kg. At 2.5 g/kg, moderate erythema and slight to moderate edema were observed. At 5 g/kg, moderate to severe erythema and moderate edema were observed. In another study in rabbits, 3-phenyl-1-propanol was applied for 24 hr under occlusion at 5 g/kg. Moderate to severe erythema, severe edema, scaling and necrosis were observed. A 0.5 mL aliquot of 3-phenylpropanol was applied to intact and abraded skin for 24 hr under occlusion. Moderate irritation was observed. Necrosis was also observed. No mutagenic or genotoxic activity in bacteria and mammalian cell line assay was found.
来源:Hazardous Substances Data Bank (HSDB)
