4-二甲氧甲基-2-甲基嘧啶 | 175277-33-5

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4-二甲氧甲基-2-甲基嘧啶
• 中文别名: 4-(二甲氧甲基)-2-甲基嘧啶；2-甲基-4-二甲氧甲基嘧啶；4-二甲氧基甲基-2-甲基嘧啶
• 英文名称: 4-(dimethoxymethyl)-2-methylpyrimidine
• CAS: 175277-33-5
• 化学式: C₈H₁₂N₂O₂
• mdl: MFCD00085137
• 分子量: 168.195
• InChiKey: VDXHJWMLYFVGDL-UHFFFAOYSA-N

物化性质

• 沸点：
  119 °C
• 密度：
  1.085±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S24/25
• 海关编码：
  2933599090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

SDS

Name:	4-(Dimethoxymethyl)-2-methylpyrimidine 97% Material Safety Data Sheet
Synonym:	2-Methylpyrimidine-4-carboxaldehyde dimethylaceta
CAS:	175277-33-5

Section 1 - Chemical Product MSDS Name:4-(Dimethoxymethyl)-2-methylpyrimidine 97% Material Safety Data Sheet
Synonym:2-Methylpyrimidine-4-carboxaldehyde dimethylaceta

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
175277-33-5	4-(Dimethoxymethyl)-2-methylpyrimidine	97%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 175277-33-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 119 - 123 deg C @5mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H12N2O2
Molecular Weight: 168

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, acids, bases, amines.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 175277-33-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-(Dimethoxymethyl)-2-methylpyrimidine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 175277-33-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 175277-33-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 175277-33-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-二甲氧甲基-2-甲基嘧啶 在 水 、 氢溴酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 2-甲基-4-嘧啶甲醛
  参考文献：
  名称：

  [EN] PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS
  [FR] PYRIMIDINYLPYRAZOLES UTILISES COMME INHIBITEURS DE TGF-BETA

  摘要：

  这项发明是基于发现，式(I)的化合物具有与Alk 5和/或Alk 4的高亲和力，并可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。该发明涉及式(I)的化合物及其用途：式(I)。

  公开号：

  WO2006026305A1
• 作为产物：
  描述：

  4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one 、 盐酸乙脒 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 4-二甲氧甲基-2-甲基嘧啶
  参考文献：
  名称：

  WO2008/62011

  摘要：

  公开号：

文献信息

• [EN] PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS<br/>[FR] PYRIMIDINYLPYRAZOLES UTILISES COMME INHIBITEURS DE TGF-BETA
  申请人：BIOGEN IDEC INC

  公开号：WO2006026305A1

  公开（公告）日：2006-03-09

  The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).

  这项发明是基于发现，式(I)的化合物具有与Alk 5和/或Alk 4的高亲和力，并可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。该发明涉及式(I)的化合物及其用途：式(I)。
• [EN] SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1 (2H)-ONE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONES SUBSTITUÉS UTILISÉS COMME INHIBITEURS DE KINASE
  申请人：ASTRAZENECA AB

  公开号：WO2016162325A1

  公开（公告）日：2016-10-13

  Compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 have any of the meanings defined hereinbefore in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer are disclosed.

  公式（I）的化合物或其药用盐，其中R1、R2、R3、R4、R5和R6具有在描述中定义的任意含义，揭示了它们的制备方法、含有它们的药物组合物以及它们在癌症治疗中的用途。
• Pyrimidinylpyrazoles as Tgf-Beta Inhibitors
  申请人：Lee Wen-Cherng

  公开号：US20080171755A1

  公开（公告）日：2008-07-17

  The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).

  该发明基于发现，公式（I）化合物具有高亲和力与Alk 5和/或Alk 4，并可用作其拮抗剂，用于预防和/或治疗多种疾病，包括纤维化疾病。该发明涉及公式（I）的化合物及其用途：公式（I）。
• Pyrimidylmethyl-Sulfonamide Compounds
  申请人：Lohmann Jan Klaas

  公开号：US20100069243A1

  公开（公告）日：2010-03-18

  The present invention relates to novel pyrimidylmethyl-sulfonamide compounds and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also to agricultural compositions comprising at least one such compound as active component, and also to their use for controlling harmful fungi. The present invention also relates to a method for controlling arthropod pests.

  本发明涉及新型嘧啶基甲基磺酰胺类化合物及其N-氧化物，其农业可接受盐和兽医可接受盐，以及包含至少一种该化合物作为活性成分的农业组合物，以及其用于控制有害真菌的用途。本发明还涉及一种控制节肢动物害虫的方法。
• Pyrimidylmethyl-sulfonamide compounds
  申请人：BASF SE

  公开号：US08178540B2

  公开（公告）日：2012-05-15

  The present invention relates to novel pyrimidylmethyl-sulfonamide compounds and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also to agricultural compositions comprising at least one such compound as active component, and also to their use for controlling harmful fungi. The present invention also relates to a method for controlling arthropod pests.

  本发明涉及新型嘧啶基甲基磺酰胺化合物及其N-氧化物，其农业上可接受的盐和兽医上可接受的盐，以及至少包含一种该化合物作为活性成分的农业组合物，还涉及它们用于控制有害真菌的用途。本发明还涉及一种控制节肢动物害虫的方法。