苄叉丙酮 | 1896-62-4

• 物质功能分类: 化学试剂 - 有机试剂 - 脂肪酮(含烯醇)
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苄叉丙酮
• 中文别名: (E)-苄叉丙酮；反式-4-苯基-3-丁烯-2-酮；反式苯亚甲基丙酮；BAR；TC-BAR
• 英文名称: (E)-benzalacetone
• 英文别名: trans-4-phenylbut-3-en-2-one；benzalacetone；(E)-4-phenylbut-3-en-2-one；(E)-4-phenyl-3-buten-2-one；benzylidene acetone；trans-benzalacetone；trans-benzylidene acetone；trans-4-phenyl-3-butene-2-one；trans-4-phenyl-3-buten-2-one；Benzylideneacetone
• CAS: 1896-62-4
• 化学式: C₁₀H₁₀O
• mdl: MFCD00008779
• 分子量: 146.189
• InChiKey: BWHOZHOGCMHOBV-BQYQJAHWSA-N

物化性质

• 熔点：
  39-42 °C(lit.)
• 沸点：
  260-262 °C(lit.)
• 密度：
  1,038 g/cm3
• 闪点：
  150 °F
• 溶解度：
  易溶（lit.）于酒精
• 物理描述：
  Solid
• 蒸汽压力：
  0.01 mmHg
• 保留指数：
  1346.2;1337;1323
• 稳定性/保质期：
  对光照敏感，请避免与不相容的材料或光照直接接触。

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 副作用

皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• 危险等级：
  9
• 危险品标志：
  Xn,Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38,R42/43,R43
• WGK Germany：
  3
• 海关编码：
  2914399090
• 危险品运输编号：
  UN 3077 9/PG III
• RTECS号：
  EN0330050
• 包装等级：
  III
• 危险类别：
  9
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H315,H317,H319,H335
• 储存条件：
  密封保存，应储存在阴凉、干燥的库房中，避免阳光直接照射。

SDS

Name:	trans-4-Phenyl-3-buten-2-one p.a. Material Safety Data Sheet
Synonym:	trans-Benzalacetone; trans-Benzylideneacetone; 3-Buten-2-one, 4-phenyl-, (E)-; Methyl trans-styryl ketone; TPBO; trans-4-Phenylbut-3-en-2-on
CAS:	1896-62-4

Section 1 - Chemical Product MSDS Name:trans-4-Phenyl-3-buten-2-one p.a. Material Safety Data Sheet
Synonym:trans-Benzalacetone; trans-Benzylideneacetone; 3-Buten-2-one, 4-phenyl-, (E)-; Methyl trans-styryl ketone; TPBO; trans-4-Phenylbut-3-en-2-on

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1896-62-4	trans-4-Phenyl-3-buten-2-one	>99.0	217-587-6

Hazard Symbols: XI
Risk Phrases: 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

---

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1896-62-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: yellowish
Odor: coumarin
pH: Not available.
Vapor Pressure: 0.009 mmHg @ 25
Viscosity: Not available.
Boiling Point: 260 - 262 deg C @ 7
Freezing/Melting Point: 39.8 deg C
Autoignition Temperature: Not applicable.
Flash Point: 122 deg C ( 251.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Negligible.
Specific Gravity/Density: Not available.
Molecular Formula: C6H5CH=CHCOCH3
Molecular Weight: 146.19

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. May discolor on exposure to light.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Direct light, strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1896-62-4: EN0330050 LD50/LC50:
Not available.
Carcinogenicity:
trans-4-Phenyl-3-buten-2-one - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 1896-62-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1896-62-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1896-62-4 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生物活性

trans-Benzylideneacetone (trans-Benzalacetone) 是革兰氏阴性致病性线虫细菌嗜线虫 (Xenorhabdus nematophila) 的代谢产物，是针对磷脂酶 A2 (PLA2) 的酶抑制剂。此外，它还是一种免疫抑制剂。

靶点

| PLA2 |

体外研究

Benzylideneacetone（trans-Benzylideneacetone）在不同浓度下对菜粉蝶幼虫血细胞扩展行为有抑制作用，并能增强苏云金杆菌 (Bacillus thuringiensis) 对菜粉蝶的危害性。

用途

• 镀锌光亮剂
• 晶粒细化剂

用于有机合成中间体、染色媒染剂、固着剂，制取香料或增香剂、香料防挥发剂以及镀锌增光剂。

类别

易燃液体

可燃性危险特性

• 易燃
• 燃烧时产生刺激烟雾

储运特性

• 通风低温干燥

灭火剂

• 干粉
• 泡沫
• 沙土
• 二氧化碳
• 雾状水

反应信息

• 作为反应物：
  描述：

  苄叉丙酮 在 sodium tetrahydroborate 、 potassium phosphate 、 C₄₅H₄₅N₉Ni⁽²⁺⁾*2CF₃O₃S^(1-) 作用下， 以 甲醇 、 苯 为溶剂， 反应 16.0h， 生成 (E)-1,3-diphenyl-1-butene
  参考文献：
  名称：

  N-杂环碳镍配合物直接合成的原位环闭合策略及其在芳醇与芳基硼酸偶联中的应用

  摘要：

  为合成N杂环卡宾镍络合物开发了一种原位闭环策略。该过程在空气中进行，不需要溶剂纯化。研究了所得的镍络合物作为烯丙基醇与芳基硼酸偶联的催化剂。广泛的烯丙基底物和芳基酸被证明可用于该催化体系。对照实验表明，Ni（0）可能是偶联反应中真正的活性物质。

  DOI：

  10.1002/adsc.202000186
• 作为产物：
  描述：

  3-苯基环丁酮 在 三氟乙酸 作用下， 生成 苄叉丙酮
  参考文献：
  名称：

  酸催化碳碳杂解反应性

  摘要：

  平衡和速率常数已经确定了酸催化的两种醇、9-xanthydrol 和对茴香基二苯基甲醇和两种硫化物、(9-xanthyl) 甲基硫化物和 (7-tropyl) 甲基硫化物的杂解。将这些数据与文献信息与酸催化 CC 杂解的速率常数进行了比较，其中包括几种（9-xanthyl）化合物、（7-tropyl）化合物、一组 3-芳基环丁酮和两种 2-芳基硝基环丙烷，所有这些都是碎片到碳正离子加上以碳为中心的离核剂。除了通过协同机制在三氟乙酸中裂解的 2-芳基硝基环丙烷外，裂解机制显示为 A1 或 A1（离子对）。几个无应变底物组之间的速率比较表明，以 O 为中心的核离心剂经历了酸催化的异解作用。10 3 -10 4 比以 S 为中心的离心机快 10 3 -10 4。10 9 -10 14 比此处使用的以 C 为中心的离心机快。有助于 CC 异种分解（及其有效性）的因素包括培养基的酸度（强）；离核剂的

  DOI：

  10.1139/cjc-77-5-6-1009
• 作为试剂：
  描述：

  <1R-<1α(S^*),3aβ,4α,7aα>>-4-acetoxyoctahydro-α,7a-dimethyl-1H-indene-1-acetaldehyde 在 palladium 10% on activated carbon 苄叉丙酮 作用下， 以 乙醚 为溶剂， 反应 45.67h， 以51%的产率得到acetic acid (3aR,4S,7aR )-1-E-ethyIidene-7a-methyI-octahydroinden-4-yl ester
  参考文献：
  名称：

  WO2008/34908

  摘要：

  公开号：

文献信息

• Dimethylhydrazone substituierter 4-Phenyl-3-buten-2-one
  作者：Bernard Unterhalt

  DOI：10.1002/ardp.19823150215

  日期：——

  Dimethylhydrazone 2 einiger substituierter 4‐Phenyl‐3‐buten‐2‐one 1 dargestellt und Versuche zur Trennung der flüssigen (E/Z)‐isomeren Produkte unternommen. Es gelingt, die (E)‐Form des 4‐(4′‐Methylphenyl)‐3‐buten‐2‐on‐dimethylhydrazons (4) kristallin zu gewinnen. Die 1H‐, 13C‐ und 15N‐NMR‐Spektren von 4 werden mit den entsprechenden Spektren des Gemisches 2a verglichen, auf Übereinstimmungen mit den 1H‐ und 13C‐NMR‐Spektren

  介绍了一些取代的 4-苯基-3-丁烯-2-酮 1 的二甲基腙 2 并尝试分离液体 (E / Z) 异构产物。4-(4'-甲基苯基)-3-丁烯-2-一-二甲基腙(4)的(E)形式可以结晶形式获得。将 4 的 1H、13C 和 15N NMR 光谱与混合物 2a 的相应光谱进行比较，并指出与类似肟的 1H 和 13C NMR 光谱一致。
• Application of Pd Nanoparticles Supported on Mesoporous Hollow Silica Nanospheres for the Efficient and Selective Semihydrogenation of Alkynes
  作者：Oscar Verho、Haoquan Zheng、Karl P. J. Gustafson、Anuja Nagendiran、Xiaodong Zou、Jan-E. Bäckvall

  DOI：10.1002/cctc.201501112

  日期：2016.2

  Herein, the preparation of a heterogeneous catalyst consisting of 1–2 nm sized Pd nanoparticles supported on amino‐functionalized mesoporous hollow silica nanospheres and its use for the semihydrogenation of mono‐ and disubstituted alkynes is reported. By utilizing this Pd nanocatalyst together with the green poisoning agent DMSO, high yields of the desired alkenes could be achieved, while suppressing

  在本文中，报道了由负载在氨基官能化介孔空心二氧化硅纳米球上的1-2 nm大小的Pd纳米颗粒组成的非均相催化剂的制备及其在单和双取代炔烃的半氢化反应中的应用。通过将此Pd纳米催化剂与绿色中毒剂DMSO一起使用，可以实现所需烯烃的高收率，同时抑制了烷烃过度还原的程度。令我们高兴的是，Pd纳米催化剂对炔烃部分表现出卓越的化学选择性，从而可以在其他可还原的官能团（例如卤素，羰基和硝基）存在下进行转化。
• Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition‐Metal Catalysts
  作者：Jan Seliger、Martin Oestreich

  DOI：10.1002/anie.202010484

  日期：2021.1.4

  A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition‐metal‐catalyzed alcohol racemization and enantioselective Cu‐H‐catalyzed dehydrogenative Si‐O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization

  报道了无环和环状苯甲醇的非酶动态动力学拆分。该方法融合了快速过渡金属催化的醇外消旋化和对映选择性 Cu-H 催化的醇和氢硅烷的脱氢 Si-O 偶联。催化过程是正交的，并且外消旋催化剂不会促进任何背景反应，例如甲硅烷基醚的外消旋及其非选择性形成。常用的钌半夹心配合物并不合适，但双功能钌钳形配合物完美地实现了这一目的。由此，可以高产率和良好的对映选择水平实现外消旋醇混合物的对映选择性硅烷化。
• A Convenient and Selective Palladium-Catalyzed Aerobic Oxidation of Alcohols
  作者：Saravanan Gowrisankar、Helfried Neumann、Dirk Gördes、Kerstin Thurow、Haijun Jiao、Matthias Beller

  DOI：10.1002/chem.201302526

  日期：2013.11.18

  An efficient procedure for the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, with molecular oxygen under ambient conditions has been achieved. By applying catalytic amounts of Pd(OAc)2 in the presence of tertiary phosphine oxides (OPR3) as ligands, a variety of substrates are selectively oxidized without formation of ester byproducts. Spectroscopic investigations

  已经实现了在环境条件下用分子氧将伯醇和仲醇分别氧化为醛和酮的有效方法。通过应用催化量的Pd（OAC）的2在叔膦氧化物（OPR的存在3）作为配体，在各种基材的而不形成酯的副产物的选择性氧化。光谱研究和DFT计算表明，氧化膦配体可稳定活性钯（II）催化剂。
• Selective aerobic oxidation of allylic and benzylic alcohols catalyzed by N-hydroxyindole and copper(I) chloride
  作者：Shu-Su Shen、Vita Kartika、Ying Shan Tan、Richard D. Webster、Koichi Narasaka

  DOI：10.1016/j.tetlet.2011.12.058

  日期：2012.2

  1-hydroxy-2-methyl-6-trifluoromethyl-1H-indole-3-carboxylate acted as a catalyst for the chemoselective aerobic oxidation of allylic and benzylic alcohols. A variety of primary and secondary allylic and benzylic alcohols were oxidized into the corresponding α,β-unsaturated carbonyl compounds in good yields without affecting non-allylic alcohols.

  在氯化铜（I）的存在下，1-羟基-2-甲基-6-三氟甲基-1 H-吲哚-3-羧酸叔丁酯用作烯丙基和苄基醇的化学选择性好氧氧化的催化剂。各种一次和二次烯丙基和苄基醇的被氧化成相应的α，β -以良好产率的不饱和羰基化合物在不影响非烯丙基醇。

表征谱图