抑制剂简介
抑制剂是一类能够降低或阻止生物体内的酶活性、受体的活性或是细胞内特定反应过程的小分子化合物。它们在有机化学、化学化工和生物医药领域中有着广泛的应用,尤其是在药物研发方面。
分类与作用机制
应用领域
总结
抑制剂的研究和发展对于理解生命过程至关重要,并在药物开发、基础科学研究等多个领域发挥着重要作用。随着技术的进步,新的抑制剂不断被发现和开发出来,为医学治疗提供了更多的可能性。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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7-(二乙胺基)-2-氧代-2-苯并吡喃-3-羧酸N-琥珀酰亚胺酯 | 7-(N,N-diethylamino)coumarin-3-carboxylic acid succinimidyl ester | 139346-57-9 | C18H18N2O6 |
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7-(5-甲基-2-呋喃基)-3-[[6-[[[(3S)-四氢-3-呋喃基]氧基]甲基]-2-吡啶基]甲基]-3H-1,2,3-三唑并[4,5-d]嘧啶-5-胺 | CPI-444 | 1202402-40-1 | C20H21N7O3 |
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7-(3,5-二甲基异噁唑-4-基)-8-甲氧基-1-((R)-1-(吡啶-2-基)乙基)-1H-咪唑并[4,5-c]喹啉-2(3H)-酮 | I-BET151 | 1300031-49-5 | C23H21N5O3 |
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6-硝基-1H-1lambda~6~-苯并[b]噻吩-1,1-二酮 | stattic | 19983-44-9 | C8H5NO4S |
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6-甲氧基-3-吡啶羧胺 | 6-methyoxy-3-pyridinecarboxamide | 7150-23-4 | C7H8N2O2 |
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6-甲基-5-(1-甲基-1H-吡唑-5-基)-N-((5-甲基磺基)吡啶-2-基)甲基)-2-氧代-1-(3-三氟甲基)苯基)-1,2-二氢吡啶-3-甲酰胺 | alvelestat | 848141-11-7 | C25H22F3N5O4S |
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6-溴-3-(1-甲基-1H-吡唑-4-基)-5-(3R)-3-哌啶基吡唑并[1,5-A]嘧啶-7-胺 | SCH 900776 | 891494-63-6 | C15H18BrN7 |
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6-氰基-N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-1-(1-乙基丙基)-1H-吲哚-4-甲酰胺 | 6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide | 1418308-27-6 | C23H26N4O2 |
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6-氯-5-[4-(1-(羟基环丁基)苯基]-1H-吲哚-3-羧酸 | PF-06409577 | 1467057-23-3 | C19H16ClNO3 |
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6-氯-2-乙基-N-[4-[4-[4-(三氟甲氧基)苯基]-1-哌啶]苄基]咪唑并[1,2-a]吡啶-3-甲酰胺 | Q203 | 1334719-95-7 | C29H28ClF3N4O2 |
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6-氯-2,3,4,9-四氢-1H-咔唑-1-羧酰胺 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid amide | 49843-98-3 | C13H13ClN2O |
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6-氨基-N-[3-[4-(4-吗啉基)吡啶并[3',2':4,5]呋喃并[3,2-D]嘧啶-2-基]苯基]-3-吡啶甲酰胺 | 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide | 371942-69-7 | C25H21N7O3 |
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6-氨基-8-[(6-碘-1,3-苯并二茂-5-基)硫基]-N-异丙基-9H-嘌呤-9-丙胺 | 8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine | 873436-91-0 | C18H21IN6O2S |
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6-二氨基-5-亚硝基嘧啶 | NU 6027 | 220036-08-8 | C11H17N5O2 |
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6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-噻唑并[4,3-B]吡嗪-3-基]甲基]-喹啉 | JNJ-38877605 | 943540-75-8 | C19H13F2N7 |
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6-[[7-[(1-氨基环丙基)甲氧基]-6-甲氧基-4-喹啉基]氧基]-N-甲基-1-萘甲酰胺 | lucitanib | 1058137-23-7 | C26H25N3O4 |
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6-[[6-(1-甲基-1H-吡唑-4-基)咪唑并[1,2-B]哒嗪-3-基]甲基]喹啉 | NVP-BVU972 | 1185763-69-2 | C20H16N6 |
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6-[[6-(1-甲基-1H-吡唑-4-基)-1,2,4-噻唑并[4,3-b]吡嗪-3-基]硫代]喹啉 | SGX523 | 1022150-57-7 | C18H13N7S |
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6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-2H-吡啶并[3,2-b]-1,4-噁嗪-3(4H)-酮 | 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | 841290-80-0 | C22H23FN6O5 |
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6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-2H-吡啶并[3,2-B]-1,4-恶嗪-3(4H)-酮苯磺酸盐 | R406 | 841290-81-1 | C6H6O3S*C22H23FN6O5 |
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6-[[3-[(二甲基氨基)羰基]苯基]磺酰]-4-[(3-甲氧基苯基)氨基]-8-甲基-3-喹啉甲酰胺 | GSK256066 | 801312-28-7 | C27H26N4O5S |
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6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-d]嘧啶-4-胺 | {6-[4-(4-ethylpiperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1-phenylethyl)amine | 497839-62-0 | C27H32N6 |
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6-[(4-((3-(甲磺酰基)苄基)氨基)-5-三氟甲基嘧啶-2-基)氨基]-3,4-二氢-1H-喹啉-2-酮 | PF573228 | 869288-64-2 | C22H20F3N5O3S |
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6-(4-甲基-1-哌嗪基)-N-(5-甲基-1H-吡唑-3-基)-2-[(1E)-2-苯乙烯基]-4-嘧啶胺 | ENMD-2076 | 934353-76-1 | C21H25N7 |
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6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-d]嘧啶-7(8H)-酮 | 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one | 260415-63-2 | C21H16Cl2N4OS |
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6-(1H-咪唑-1-基)-2-苯基-喹唑啉 | CR4056 | 1004997-71-0 | C17H12N4 |
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6-(1H-吲哚-5-基)-4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶 | 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine | 1062159-35-6 | C28H30N8O |
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6-(1,3-二氢-4-羟基-6-甲氧基-7-甲基-3-氧代-5-异苯并呋喃基)-4-甲基己-4-烯酸 | mycophenolic acid | 483-60-3 | C17H20O6 |
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6-((2-((4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基)氨基)乙基)氨基)烟腈单盐酸盐 | CHIR-99021 HCl | 1797989-42-4 | C22H19Cl3N8 |
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6,8-双(苄基硫代)辛酸 | CPI-613 | 95809-78-2 | C22H28O2S2 |
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6,7-二甲氧基-2-苯基喹喔啉 | 6,7-dimethoxy-3-phenylquinoxaline | 146535-11-7 | C16H14N2O2 |
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5-羰基-8-羟基喹啉 | 8-hydroxy-quinoline-5-carboxylic acid | 5852-78-8 | C10H7NO3 |
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5-甲氧基邪蒿素 | 5-methoxyseselin | 31525-76-5 | C15H14O4 |
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5-溴-N-(2,3-二羟基丙氧基)-3,4-二氟-2-[(2-氟-4-碘苯基)氨基]苯甲酰胺 | PD318088 | 391210-00-7 | C16H13BrF3IN2O4 |
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5-氯-N2-[4-[4-(二甲基氨基)-1-哌啶基]-2-甲氧基苯基]-N4-[2-(二甲基亚膦酰)苯基]-2,4-嘧啶二胺 | AP26113 | 1197958-12-5 | C26H34ClN6O2P |
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5-氯-N2-[2-甲氧基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-N4-[2-[(1-甲基乙基)磺酰基]苯基]-2,4-嘧啶二胺 | 5-chloro-N4-[2-(isopropylsulfonyl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | 761439-42-3 | C30H40ClN7O3S |
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5-氯-N2-[(1S)-1-(5-氟-2-嘧啶基)乙基]-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺 | AZD1480 | 935666-88-9 | C14H14ClFN8 |
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5-氯-N-[4-甲氧基-3-(1-哌嗪基)苯基]-3-甲基苯并[b]噻吩-2-磺胺 | 5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide | 209481-20-9 | C20H22ClN3O3S2 |
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5-氯-N-[(1S,2R)-3-(二甲基氨基)-2-羟基-3-氧代-1-(苯基甲基)丙基]-1H-吲哚-2-甲酰胺 | CP 91149 | 186392-40-5 | C21H22ClN3O3 |
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5-氯-3-乙基-N-[2-[4-(1-哌啶基)苯基]乙基-1H-吲哚-2-甲酰胺 | Org 27569 | 868273-06-7 | C24H28ClN3O |
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5-[[((2S)-2-(甲氧甲基)-1-吡咯烷基]磺酰基]-1H-吲哚-2,3-二酮 | (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin | 220509-74-0 | C14H16N2O5S |
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5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺 | N-(3-fluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide | 722544-51-6 | C26H30FN7O3 |
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5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 | (5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione | 900515-16-4 | C14H8FNO4S |
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5-[[5-(2,8-二甲基-5H-二苯并[a,d]环庚基5-基)-3,4-二氢-2-氧代-4-硫代氧代-1(2H)-嘧啶基]甲基]-N-2H-四唑-5-基-2-呋喃甲酰胺 | 5-{[5-(2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarboxamide | 216657-60-2 | C28H23N7O3S |
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5-[[4-[2-(5-乙基吡啶-2-基)乙氧基]苯基]甲基]-1,3-噻唑烷-2,4-二酮 | Pioglitazone | 111025-46-8 | C19H20N2O3S |
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5-[[3-甲氧基-4-[(4-甲氧基苯基)甲氧基]苯基]甲基]-2,4-嘧啶二胺', | GW-2580 | 870483-87-7 | C20H22N4O3 |
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5-[8-甲基-9-异丙基-2-(4-吗啉基)-9H-嘌呤-6-基]-2-嘧啶胺 | 5-(9-isopropyl-8-methyl-2-morpholin-4-yl-9H-purin-6-yl)-pyrimidin-2-ylamine | 1246560-33-7 | C17H22N8O |
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5-[4-氟-1-[(6-甲基-2-吡啶基)乙酰基]-2,3-二氢-1H-吲哚-5-基]-7-甲基-7H-吡咯并[2,3-d]嘧啶-4-胺 | GSK2656157 | 1337532-29-2 | C23H21FN6O |
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5-[4-(2-{[6-(4-甲氧基苯氧基)-4-嘧啶基](甲基)氨基}乙氧基)苄基]-1,3-噻唑烷-2,4-二酮 | lobeglitazone | 607723-33-1 | C24H24N4O5S |
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5-[2-[4-[2-(二甲基氨基)乙氧基]苯基]-5-(4-吡啶基)-1H-咪唑-4-基]-2,3-二氢-1-茚酮肟 | 1H-Inden-1-one, 5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-5-(4-pyridinyl)-1H-imidazol-4-yl)-2,3-dihydro-, oxime | 405554-55-4 | C27H27N5O2 |
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