摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词
历史搜索
    热门化合物HOT
    • 喹啉
    • 水杨醛
    • 二溴甲烷
    • 谷胱甘肽
    • L-乳酸
    • 苯巴比妥
    • 辣椒碱
    • 非那明
    • 百草枯
    • 联苯烯
    首页 分子通 按物质功能分类 生物化工 抑制剂

    抑制剂

    抑制剂简介

    抑制剂是一类能够降低或阻止生物体内的酶活性、受体的活性或是细胞内特定反应过程的小分子化合物。它们在有机化学、化学化工和生物医药领域中有着广泛的应用，尤其是在药物研发方面。

    分类与作用机制

    1. 竞争性抑制剂：这类抑制剂通过与其目标蛋白质（如酶）结合，占据其底物结合位点，从而阻止真正的底物与蛋白质的正常结合。这种类型的抑制通常可以通过增加底物浓度来缓解。
    2. 非竞争性抑制剂：非竞争性抑制剂通过改变蛋白质的功能状态或结构，而不直接与其活性部位相结合。它们可能会影响蛋白质的构象变化或者与其他位点相互作用。
    3. 不可逆抑制剂：这类抑制剂与酶或其他生物分子形成共价键，导致其永久失去功能。由于这种特性，此类抑制剂通常用于实验室研究中。

    应用领域

    1. 药物开发：在生物医药领域，抑制剂被广泛用作潜在的治疗药物，用于对抗各种疾病如癌症、病毒感染等。
    2. 酶学研究：有机化学和生物化学研究经常使用特定类型的抑制剂来探究酶的功能和作用机理。
    3. 合成与催化：化学化工中，通过调节反应条件或引入适当的抑制剂可以提高某些目标产物的选择性。

    总结

    抑制剂的研究和发展对于理解生命过程至关重要，并在药物开发、基础科学研究等多个领域发挥着重要作用。随着技术的进步，新的抑制剂不断被发现和开发出来，为医学治疗提供了更多的可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    (+)-抗生素K252A K-252a 99533-80-9 C27H21N3O5
    (+)-抗生素K252A
    (+)-噻奈普汀单钠盐 tianeptine sodium 54317-11-2 C21H24ClN2O4S*Na
    (+)-噻奈普汀单钠盐
    (+)-(S)-2-氨基-1-(4-氯苯基)-1-[4-(1H-吡唑-4-基)苯基]乙醇 ((1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol) 1056901-62-2 C17H16ClN3O
    (+)-(S)-2-氨基-1-(4-氯苯基)-1-[4-(1H-吡唑-4-基)苯基]乙醇
    ((S)-4-甲基-1-氧代-1-(((S)-1-氧代己烷-2-基)氨基)戊-2-基)氨基甲酸苄酯 calpeptin 117591-20-5 C20H30N2O4
    ((S)-4-甲基-1-氧代-1-(((S)-1-氧代己烷-2-基)氨基)戊-2-基)氨基甲酸苄酯
    —— N-(5-cyclobutyl-2H-pyrazol-3-yl)-2-naphthalene-2-yl-acetamide 865317-30-2 C19H19N3O
    N-(5-cyclobutyl-2H-pyrazol-3-yl)-2-naphthalene-2-yl-acetamide
    —— [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride 105826-92-4 C17H21ClN2O2
    [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride
    —— PD 128907 (hydrochloride) 112960-16-4 C14H20ClNO3
    PD 128907 (hydrochloride)
    —— N-(tert-Butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide 2095616-82-1 C32H31N3O5S
    N-(tert-Butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide
    —— 4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate 1542213-67-1 C2HF3O2*C17H17ClF3N5OS
    4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate
    —— pseudoscopine 498-45-3 C8H13NO2
    pseudoscopine
    —— Bis-PEG25-NHS ester 2221948-96-3 C62H112N2O33
    Bis-PEG25-NHS ester
    —— Mayzent 2768181-14-0 C29H35F3N2O3
    Mayzent
    —— 2170848-99-2 C10H8BFO5.2Na
    —— Mitiperstat 1933460-19-5 C15H15ClN4OS
    Mitiperstat
    —— Tak-041 1929519-13-0 C18H15F3N4O3
    Tak-041
    —— 5-Chloro-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one 186611-56-3 C15H13ClN2O
    5-Chloro-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
    —— 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine 891495-88-8 C15H18BrN7
    6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
    —— (S)-3-[3-(tert-butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate 26921-17-5 C17H28N4O7S
    (S)-3-[3-(tert-butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate
    —— 3-(6-chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]-hexane hydrochloride 2414674-71-6 C11H13ClN2O*ClH
    3-(6-chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]-hexane hydrochloride
    —— Nafamostat dimethanesulfonate 82956-11-4 C21H25N5O8S2
    Nafamostat dimethanesulfonate
    —— 4-(((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)-trans-cyclohexyl)propan-2-ol hydrochloride 1418143-09-5 C22H25F3N4O*ClH
    4-(((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)-trans-cyclohexyl)propan-2-ol hydrochloride
    —— LY3502970 2212020-52-3 C48H48F2N10O5
    LY3502970
    —— 4-(2-aminoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 390367-50-7 C15H15N3O5
    4-(2-aminoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
    —— Valemetostat tosylate 1809336-93-3 C33H42ClN3O7S
    Valemetostat tosylate
    —— 4-((1-methyl-1H-pyrrol-2-yl)methylene)isoquinoline-1,3(2H,4H)-dione 1104546-89-5 C15H12N2O2
    4-((1-methyl-1H-pyrrol-2-yl)methylene)isoquinoline-1,3(2H,4H)-dione
    —— 5-(6-Quinolinylmethylidene)-2-(thiophen-2-ylmethylamino)-4-thiazolone 872573-93-8 C18H13N3OS2
    5-(6-Quinolinylmethylidene)-2-(thiophen-2-ylmethylamino)-4-thiazolone
    —— (1R,3S,5S)-3-{6-[(3R)-3-methylmorpholin-4-yl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl}-8-oxabicyclo[3.2.1]octan-3-ol 2417489-10-0 C21H26N6O3
    (1R,3S,5S)-3-{6-[(3R)-3-methylmorpholin-4-yl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl}-8-oxabicyclo[3.2.1]octan-3-ol
    —— XD14 1370888-71-3 C20H27N3O5S
    XD14
    —— Mrtx0902 2654743-22-1 C22H24N6O
    Mrtx0902
    —— QPX7728 2170834-63-4 C10H8BFO4
    QPX7728
    —— (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-phenyl-1H-indazol-5-yl)pyrrolidine-3-carboxamide 942183-80-4 C34H34N8O2
    (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-phenyl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
    —— (2E)-3-{4-[(6-Deoxy-alpha-L-xylo-hexofuranosyl-5-ulose)oxy]-3-hydroxyphenyl}-2-methyl-N-[(3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxyhexahydro-1,3-benzodioxol-5-yl]acrylamide 6379-56-2 C23H29NO12
    (2E)-3-{4-[(6-Deoxy-alpha-L-xylo-hexofuranosyl-5-ulose)oxy]-3-hydroxyphenyl}-2-methyl-N-[(3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxyhexahydro-1,3-benzodioxol-5-yl]acrylamide
    —— (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide 2364554-48-1 C18H19N5O2
    (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide
    —— IWR-1 1127442-82-3 C25H19N3O3
    IWR-1
    —— TPX-0131 2648641-36-3 C21H20F3N5O3
    TPX-0131
    —— (2,5-dioxopyrrolidin-1-yl) 4-[[3-[5-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-2-methyl-5-oxopentan-2-yl]sulfanyl-2,5-dioxopyrrolidin-1-yl]methyl]cyclohexane-1-carboxylate 1228105-52-9 C54H72ClN5O16S
    (2,5-dioxopyrrolidin-1-yl) 4-[[3-[5-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-2-methyl-5-oxopentan-2-yl]sulfanyl-2,5-dioxopyrrolidin-1-yl]methyl]cyclohexane-1-carboxylate
    —— Dxd 1599440-33-1 C26H24FN3O6
    Dxd
    —— 11β,21-Dihydroxy-16α,17α-isopropylidendioxy-3.20-dioxo-pregnadien-(1.4) 638-94-8 C24H32O6
    11β,21-Dihydroxy-16α,17α-isopropylidendioxy-3.20-dioxo-pregnadien-(1.4)
    —— doxycycline hydrochloride 10592-13-9 C22H24N2O8*ClH
    doxycycline hydrochloride
    —— LCZ696 936623-90-4 C24H27N5O3*C24H28NO5*2H2O*3Na
    LCZ696
    —— Sodium orthovanadate 13721-39-6 3Na*O4V
    Sodium orthovanadate
    —— fidaxomicin 873857-62-6 C52H74Cl2O18
    fidaxomicin
    —— ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester 854402-59-8 C25H37N3O7
    ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
    —— (+/-)-K252a 99533-80-9 C27H21N3O5
    (+/-)-K252a
    —— ciliobrevin A 302803-72-1 C17H9Cl2N3O2
    ciliobrevin A
    —— CFTRinh-172 307510-92-5 C18H10F3NO3S2
    CFTRinh-172
    —— PF-00835231 870153-29-0 C24H32N4O6
    PF-00835231
    —— voxilaprevir 1535212-07-7 C40H52F4N6O9S
    voxilaprevir
    —— epothilone A 152044-53-6 C26H39NO6S
    epothilone A
    —— flavopiridol hydrochloride 131740-09-5 C21H20ClNO5*ClH
    flavopiridol hydrochloride