Stable under normal temperatures and pressures.
α-倒捻子素是从山竹子中提取的一种氧杂蒽酮类化合物,源于天然山竹子的有效成分。它具有安全无毒及悠久食用历史等特点,为深入研究α-倒捻子素作为药物提供了理论和应用基础。
生物活性α-倒捻子素(alpha-MangOSa href=https://www.molaid.com/MS_19470 target="_blank">STin)是一种具有广泛生物活性的膳食呫吨酮,包括抗氧化、抗过敏、抗病毒、抗菌、抗炎及抗癌作用。它也是IDH1突变体(如IDH1-R132H)的抑制剂,Ki值为2.85 μM。
靶点α-倒捻子素对IDH1-R132H表现出选择性抑制效果,但不抑制IDH1。它以竞争性方式抑制α-酮戊二酸(α-KG)与IDH1-R132H的结合,并在IDH1 (+/R132H) MCF10A细胞中促进5-甲基胞嘧啶和组蛋白H3精氨酸三甲基化位点的去甲基化。在用α-倒捻子素处理的细胞中,细胞增殖以剂量依赖性方式显著减少。α-倒捻子素还增加Bax(促凋亡)、裂解 caspase-3、裂解 caspase-9 和裂解-PARP 的水平。
此外,它显著抑制光诱导的视网膜色素上皮细胞退化及200 μM H₂O₂诱导的RPE细胞凋亡。H₂O₂诱导的活性氧(ROS)生成和光诱导的丙二醛(MDA)生成也被α-倒捻子素抑制。
体内研究α-倒捻子素通过减少p53表达,降低TAA_DMSO治疗后的肝纤维化风险。与单独使用DMSO相比,在用α-倒捻子素处理后,血清中转氨酶(AST和ALT)的水平显著下降。
化学性质α-倒捻子素是一种白色结晶粉末,可溶于甲醇、乙醇及DMSO等有机溶剂。它来源于藤黄科山竹壳、罗汉果及山竺。
用途α-倒捻子素具有治疗腹泻、疟疾、抗炎、抗溃疡以及抗白血病和败血症的作用,可用于含量测定/鉴定/药理实验等。其药理活性包括抗氧化、抗炎、抗菌及抗癌作用。
中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
Β-倒捻子素 | β-mangostin | 20931-37-7 | C25H28O6 | 424.494 |
二甲基倒捻子素 | dimethylmangostin | 15404-76-9 | C26H30O6 | 438.521 |
—— | 3,6-Di-O-methyl-γ-mangostin | 132031-39-1 | C25H28O6 | 424.494 |
gamma-倒捻子素 | γ-mangostin | 31271-07-5 | C23H24O6 | 396.44 |
—— | 3,6-dimethoxy-1,7-dihydroxy-2,8-diallyl-9H-xanthone | 65697-05-4 | C21H20O6 | 368.386 |
伽升沃 D | garcinone D | 107390-08-9 | C24H28O7 | 428.482 |
—— | 6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate | 31271-10-0 | C28H30O8 | 494.541 |
—— | 1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone | 1140525-42-3 | C31H30O7 | 514.575 |
—— | Tri-O-acetylmangostin | 107389-90-2 | C30H32O9 | 536.579 |
—— | 3,6-di-O-benzoyl-α-mangostin | 1449384-89-7 | C38H34O8 | 618.683 |
—— | 1,7-dihydroxy-3,6-dimethoxyxanthone | 42833-92-1 | C15H12O6 | 288.257 |
中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
Β-倒捻子素 | β-mangostin | 20931-37-7 | C25H28O6 | 424.494 |
—— | cowaxanthone B | —— | C25H28O6 | 424.494 |
二甲基倒捻子素 | dimethylmangostin | 15404-76-9 | C26H30O6 | 438.521 |
—— | 3,6-dihydroxy-1,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | 1607022-19-4 | C25H28O6 | 424.494 |
—— | 1,3,6-trihydroxy-2,8-bis(3-methylbut-2-en-1-yl)-7-(prop-2-yn-1-yloxy)-9H-xanthen-9-one | 1607022-24-1 | C26H26O6 | 434.489 |
—— | 3-O-ethyl-α-mangostin | 1140525-46-7 | C26H30O6 | 438.521 |
—— | 6-Ethoxy-1,3-dihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | 1449384-88-6 | C26H30O6 | 438.521 |
—— | cratoxylone | —— | C24H28O7 | 428.482 |
—— | 1,3,6-tri-O-methyl-α-mangostin | —— | C27H32O6 | 452.547 |
—— | dulxanthone D | 182051-07-6 | C19H18O6 | 342.348 |
—— | 3-(allyloxy)-6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9H-xanthene-9-one | 1193121-26-4 | C27H30O6 | 450.532 |
gamma-倒捻子素 | γ-mangostin | 31271-07-5 | C23H24O6 | 396.44 |
—— | 3-O-acetyl-α-mangostin | —— | C26H28O7 | 452.504 |
—— | 3-(allyloxy)-8-hydroxy-2,6-dimethoxy-1,7-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | 1607022-18-3 | C28H32O6 | 464.558 |
—— | 3,6-Diethoxy-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | 189945-36-6 | C28H34O6 | 466.574 |
—— | 2-((6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3-yl)oxy)acetic acid | 1427187-66-3 | C26H28O8 | 468.504 |
—— | 6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate | 212842-62-1 | C26H28O7 | 452.504 |
—— | 1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-3,6-dipropoxy-9H-xanthen-9-one | —— | C30H38O6 | 494.628 |
—— | 3,6-bis(allyloxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthene-9-one | —— | C30H34O6 | 490.596 |
—— | 1-hydroxy-3,6-di-O-butyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone | 189945-38-8 | C32H42O6 | 522.682 |
—— | 3,6‐bis(4‐bromobutoxy)‐1‐hydroxy‐7‐methoxy‐2,8‐bis(3‐methylbut‐2‐en‐1‐yl)‐9H‐xanthen‐9‐one | 1427187-01-6 | C32H40Br2O6 | 680.474 |
—— | 3,6-di-O-3,3-dimethylallyl-α-mangostin | 1193121-15-1 | C34H42O6 | 546.704 |
—— | 3,6-di-pentoxy-α-mangostin | 1193121-22-0 | C34H46O6 | 550.736 |
—— | 3,6-di(3-bromopropoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1427187-00-5 | C30H36Br2O6 | 652.42 |
—— | 3,6-bis(4-aminobutoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | —— | C32H44N2O6 | 552.711 |
—— | 3,6-di[(5-bromopentyl)oxy]-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1427187-02-7 | C34H44Br2O6 | 708.528 |
—— | 3,6-di[(6-bromohexyl)oxy]-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1427187-03-8 | C36H48Br2O6 | 736.582 |
—— | 3,6-bis((8-bromooctyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C40H56Br2O6 | 792.689 |
—— | 3,6-bis((12-bromododecyl)oxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C48H72Br2O6 | 904.904 |
—— | 3,6-bis(allyloxy)-1,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | 1607022-27-4 | C31H36O6 | 504.623 |
—— | 3,6-di-O-benzyl-α-mangostin | 1193121-18-4 | C38H38O6 | 590.716 |
—— | 3,6-Bis[3-(diethylamino)propoxy]-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | 1427187-07-2 | C38H56N2O6 | 636.872 |
—— | 3,6-bis(4-(ethyl(methyl)amino)butoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C38H56N2O6 | 636.872 |
—— | 3,6-bis(4-(butyl(methyl)amino)butoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C42H64N2O6 | 692.98 |
—— | AM0016 | 1427187-17-4 | C40H60N2O6 | 664.926 |
—— | 6-bis(4-(butyl(ethyl)amino)butoxy)-1-hydroxy-7-methoxy-2,8-bis-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C44H68N2O6 | 721.034 |
—— | 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-3,6-bis(4-pyrrolidin-1-ylbutoxy)xanthen-9-one | 1427187-15-2 | C40H56N2O6 | 660.894 |
—— | 6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate | 31271-10-0 | C28H30O8 | 494.541 |
—— | 3,6-di-O-4-mehylbenzyl α-mangostin | 1193121-20-8 | C40H42O6 | 618.77 |
—— | tetrahydro-α-mangostin | 182317-42-6 | C24H30O6 | 414.499 |
—— | 2,2'-((1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl)bis(oxy))diacetic acid | 1427187-51-6 | C28H30O10 | 526.54 |
—— | 3,6-Bis[5-(diethylamino)pentoxy]-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | 1427187-04-9 | C42H64N2O6 | 692.98 |
—— | 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-3,6-bis(4-piperidin-1-ylbutoxy)xanthen-9-one | 1427187-18-5 | C42H60N2O6 | 688.948 |
—— | 3,6-Bis[6-(diethylamino)hexoxy]-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | 1427187-06-1 | C44H68N2O6 | 721.034 |
—— | 3,6-di-O-4-methoxybenzyl α-mangostin | 1193121-16-2 | C40H42O8 | 650.769 |
—— | 1-hydroxy-3,6-bis(2,3-epoxypropoxy)-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | —— | C30H34O8 | 522.595 |
3,4-二氢-5,9-二羟基-8-甲氧基-2,2-二甲基-7-(3-甲基-2-丁烯基)-2H,6H-吡喃并[3,2-b]氧杂蒽-6-酮 | 3-isomangostin | 19275-46-8 | C24H26O6 | 410.467 |
—— | dimethyl 2,2'-((1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene-3,6-diyl)bis(oxy))diacetate | 1427187-50-5 | C30H34O10 | 554.594 |
—— | 3,6-bis(4-(4-ethylpiperazin-1-yl)butoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C44H66N4O6 | 747.031 |
—— | 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-3,6-bis(4-morpholin-4-ylbutoxy)xanthen-9-one | 1427187-05-0 | C40H56N2O8 | 692.893 |
—— | 1,3-dihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9-oxo-9H-xanthen-6-yl diethylcarbamate | —— | C29H35NO7 | 509.599 |
—— | 4-methyl-3,6-di-O-methyl-α-mangostin | 1285705-91-0 | C27H32O6 | 452.547 |
—— | 1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone | 1140525-42-3 | C31H30O7 | 514.575 |
—— | 3,6-bis(3-(dipropylamino)-2-hydroxypropoxy)-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C42H64N2O8 | 724.979 |
—— | Tri-O-acetylmangostin | 107389-90-2 | C30H32O9 | 536.579 |
异曼果斯廷 | 1-isomangostin | 19275-44-6 | C24H26O6 | 410.467 |
—— | 3,6-Dihydroxy-1,7-dimethoxy-2,8-bis(3-methylbutyl)xanthen-9-one | 1449384-94-4 | C25H32O6 | 428.525 |
—— | 3-Ethoxy-1,6-dihydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449384-95-5 | C26H34O6 | 442.552 |
—— | 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-3,6-bis[4-(1,2,4-triazol-1-yl)butoxy]xanthen-9-one | 1427186-98-8 | C36H44N6O6 | 656.782 |
—— | 4-bromo-α-mangostin | 1146966-46-2 | C24H25BrO6 | 489.363 |
—— | 1-hydroxy-3,6-bis(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C38H52N2O10 | 696.838 |
—— | 1-Hydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-3,6-bis(4-pyrazol-1-ylbutoxy)xanthen-9-one | 1427187-09-4 | C38H46N4O6 | 654.806 |
—— | 4-chloro-α-mangostin | 1146966-54-2 | C24H25ClO6 | 444.912 |
—— | 1,3,6-trihydroxy-2-(3-methyl-2-butenyl)-7-methoxy-8-(2,3-dihydroxy-3-methylbutyl)xanthone | —— | C24H28O8 | 444.482 |
—— | 6-Ethoxy-1,3-dihydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1140525-47-8 | C26H34O6 | 442.552 |
—— | 3,6-di-O-benzoyl-α-mangostin | 1449384-89-7 | C38H34O8 | 618.683 |
氧杂蒽酮 I | 9-hydroxycalabaxanthone | 35349-68-9 | C24H24O6 | 408.451 |
—— | 1,3-Dihydroxy-6-(2-hydroxyethoxy)-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449384-97-7 | C26H34O7 | 458.552 |
—— | 1, 3-dihydroxy-2,8-diisopentyl-7-methoxy-9H-xanthene-9-one | 1607022-20-7 | C24H30O5 | 398.499 |
—— | 6-Allyloxy-1,3-dihydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1140525-52-5 | C27H34O6 | 454.563 |
—— | 1,3-Dihydroxy-2,8-diisopentyl-7-methoxy-6-propoxy-xanthen-9-one | 1140525-50-3 | C27H36O6 | 456.579 |
—— | 6-Butoxy-1,3-dihydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1140525-51-4 | C28H38O6 | 470.606 |
—— | 6-(4-Bromobutoxy)-1,3-dihydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449385-03-8 | C28H37BrO6 | 549.502 |
—— | 3,6-Diethoxy-1-hydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449384-96-6 | C28H38O6 | 470.606 |
—— | 1,3-Dihydroxy-2,8-diisopentyl-7-methoxy-6-pentoxy-xanthen-9-one | 1449385-07-2 | C29H40O6 | 484.633 |
—— | 3,6-Diallyloxy-1-hydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449385-01-6 | C30H38O6 | 494.628 |
—— | 1-Hydroxy-3,6-bis(2-hydroxyethoxy)-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449384-98-8 | C28H38O8 | 502.605 |
—— | 4-dimethylaminomethyl-1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | —— | C27H33NO6 | 467.562 |
—— | 3,6-Dibutoxy-1-hydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449385-02-7 | C32H46O6 | 526.714 |
3-Isomangostin hydrate; 3,4-二氢-5,9-二羟基-11-(3-羟基-3-甲基丁基)-10-甲氧基-2,2-二甲基-2H,12H-吡喃并[2,3-a]氧杂蒽-12-酮 | 3-isomangostin hydrate | 26063-96-7 | C24H28O7 | 428.482 |
—— | mangostanin | —— | C24H26O7 | 426.466 |
—— | 2-(6,8-Dihydroxy-1,7-diisopentyl-2-methoxy-9-oxo-xanthen-3-yl)oxyacetamide | 1449384-99-9 | C26H33NO7 | 471.551 |
—— | 3,6-bis(4-bromobutoxy)-1-hydroxy-2,8-diisopentyl-7-methoxy-9H-xanthen-9-one | 1449385-05-0 | C32H44Br2O6 | 684.506 |
—— | 1-hydroxy-2,8-diisopentyl-7-methoxy-9H-xanthene-9-one | 1607022-28-5 | C24H30O4 | 382.5 |
BR-氧杂蒽酮 A | BR-xanthone A | 112649-48-6 | C23H24O6 | 396.44 |
—— | 3,4-dihydro-5,9-dihydroxy-8-methoxy-7-(3-methoxy-3-methylbutyl)-2,2-dimethyl-2H,6H-pyrano-[3,2-b]xanthen-6-one | 112649-47-5 | C25H30O7 | 442.509 |
—— | 3,6-Dibenzyloxy-1-hydroxy-2,8-diisopentyl-7-methoxy-xanthen-9-one | 1449385-08-3 | C38H42O6 | 594.748 |
—— | 3,6-bistrifluoromethanesulfonyloxy-1-hydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthene | 1607022-26-3 | C26H24F6O10S2 | 674.593 |
—— | 18-O-formyl-3-isomangostin hydrate | —— | C25H28O8 | 456.493 |
—— | tert-butyl 2-[4-({[3,6,8-trihydroxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-2-yl]oxy}methyl)-1H-1,2,3-triazol-1-yl]acetate | 1607022-25-2 | C32H37N3O8 | 591.661 |
1-异倒捻子素水合物 | 1-isomangostin hydrate | 26063-95-6 | C24H28O7 | 428.482 |
—— | 2-[6-(2-Amino-2-oxo-ethoxy)-1-hydroxy-2,8-diisopentyl-7-methoxy-9-oxo-xanthen-3-yl]oxyacetamide | 1449385-00-5 | C28H36N2O8 | 528.602 |
异去甲倒捻子素 | isonormangostin | 15404-80-5 | C23H24O6 | 396.44 |
—— | ethyl 8-((5-hydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-6-oxo-2H,6H-pyrano[3,2-b]xanthen-9-yl)oxy)octanoate | —— | C34H42O8 | 578.703 |
—— | (1-Hydroxy-2,8-diisopentyl-7-methoxy-9-oxo-6-propanoyloxy-xanthen-3-yl) propanoate | 1449385-13-0 | C30H38O8 | 526.627 |
—— | (6-Butanoyloxy-1-hydroxy-2,8-diisopentyl-7-methoxy-9-oxo-xanthen-3-yl) butanoate | 1449385-14-1 | C32H42O8 | 554.681 |
—— | 4-amino-1,3,6,7-tetrahydroxy-2,8-diisopentyl-9H-xanthen-9-one | 1607022-23-0 | C24H31NO6 | 429.513 |
—— | 3-amino-8-hydroxy-1,7-diisopentyl-2-methoxy-9H-xanthene-9-one | 1607022-21-8 | C24H31NO4 | 397.514 |
—— | α-mangostin 3,6-di-O-β-D-glucopyranoside | —— | C36H46O16 | 734.752 |
—— | 1,3,6,7-tetrahydroxy-2,8-diisopentyl-4-nitro-9H-xanthen-9-one | 1607022-22-9 | C24H29NO8 | 459.496 |