dulxanthone D | 182051-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: dulxanthone D
• 英文别名: 3,6,8-trihydroxy-2-methoxy-1-(3-methyl-but-2-enyl)-xanthen-9-one；3,6,8-Trihydroxy-2-methoxy-1-(3-methyl-but-2-enyl)-xanthen-9-on；3,6,8-trihydroxy-2-methoxy-1-(3-methylbut-2-enyl)xanthen-9-one
• CAS: 182051-07-6
• 化学式: C₁₉H₁₈O₆
• 分子量: 342.348
• InChiKey: JZLXKPGAABLTJE-UHFFFAOYSA-N

物化性质

• 沸点：
  600.8±55.0 °C(Predicted)
• 密度：
  1.376±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 dulxanthone D 以 乙醚 为溶剂， 生成 1-hydroxy-3,6,7-trimethoxy-8-(3-methylbut-2-enyl)-xanthone
  参考文献：
  名称：

  来自 Garcinia griffithii 和 Garcinia mangostana 的氧杂蒽酮和二苯甲酮

  摘要：

  从藤黄的茎皮中分离出一种新的聚异戊二烯化二苯甲酮，guttiferone I，以及已知的化合物cambogin、1,7-dihydroxyxanthone、1,3,6,7-tetrahydroxyxanthone和1,3,5,6-tetrahydroxyxanthone。Garcinia mangostana 心材的丙酮提取物含有一种新的二异戊二烯化呫吨酮（mangoxanthone）和一种新的二苯甲酮（3',6-dihydroxy-2,4,4'-三甲氧基二苯甲酮）以及已知的呫吨酮 dulxanthone D, 1,3 ,7-三羟基-2-甲氧基氧杂蒽酮、1,3,5-三羟基-13,13-二甲基-2H-吡喃[7,6-b]xanthen-9-one。它们的结构是在光谱研究和化学相关性的基础上建立的。

  DOI：

  10.1016/j.phytochem.2005.04.032
• 作为产物：
  描述：

  2,4,6-tris(O-methoxymethyl)benzaldehyde 在 palladium on activated charcoal 、 camphor-10-sulfonic acid 、 仲丁基锂 、 silica gel 、 环己烯 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二甲基亚砜 、 甲苯 为溶剂， 生成 dulxanthone D
  参考文献：
  名称：

  Biological activities of α-mangostin derivatives against acidic sphingomyelinase

  摘要：

  Deprenyl and benzofenone-type congeners of alpha-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17). (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00719-4

文献信息

• Murakami, Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 125,140
  作者：Murakami

  DOI：——

  日期：——
• Yamashiro, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan, 1931, vol. 52, p. 548,552
  作者：Yamashiro

  DOI：——

  日期：——
• XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS
  申请人：DEAKIN UNIVERSITY

  公开号：EP3110414B1

  公开（公告）日：2020-09-30
• [EN] XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS<br/>[FR] EXTRAITS DE PLANTE RICHES EN XANTHONE OU COMPOSÉS DÉRIVÉS DE CEUX-CI POUR LA MODULATION DE MALADIES DU SYSTÈME NERVEUX CENTRAL ET DE TROUBLES ASSOCIÉS
  申请人：UNIV DEAKIN

  公开号：WO2015127512A1

  公开（公告）日：2015-09-03

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.
• Biological activities of α-mangostin derivatives against acidic sphingomyelinase
  作者：Motoko Hamada、Kazuhiko Iikubo、Yuichi Ishikawa、Aya Ikeda、Kazuo Umezawa、Shigeru Nishiyama

  DOI：10.1016/s0960-894x(03)00719-4

  日期：2003.10

  Deprenyl and benzofenone-type congeners of alpha-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17). (C) 2003 Elsevier Ltd. All rights reserved.