生化试剂
生化试剂（Biochemical reagent）是指用于生命科学研究的生物材料或有机化合物，以及临床诊断和医学研究所需的各类试剂。它们是从生物体中提取或通过化学合成得到的基本成分，主要用于生物成分的分析鉴定及生物制品的制造。
随着生命科学的发展，生化试剂已成长为一种重要的化学试剂类别，品种繁多，达10000多种。中国市场上销售的生化试剂有2500种。由于生化试剂对温度、湿度和光照敏感，容易丧失活力且保存期较短，因此对其贮存与运输条件要求较高。例如，绝大多数酶试剂需在0～5℃下保存，而某些用于遗传工程研究的酶试剂则需要在-20℃下冷藏。
根据生物体组织中所含物质或代谢过程中产生的物质，生化试剂可以分为氨基酸、多肽、蛋白质、核苷酸、核酸、酶、辅酶、糖类、酯类和激素等。此外，按生物学研究的需求，它们还可细分为电泳试剂、色谱试剂、免疫试剂、标记试剂以及组织化学试剂等。
不同用途的生化试剂对纯度和技术要求各不相同。例如，酶试剂通常有粗制酶、结晶酶、多次结晶酶及不含特定杂酶的酶制剂等多种形式。生产生化试剂的方法主要有三种：从生物体中分离和提纯、化学合成以及发酵等。对于生化试剂产品的技术要求包括含量、熔点、冰点、旋光度、含水量、光谱特征、折光性、密度及生物活性等。
下级分类
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| VUF11207三氟乙酸酯盐 | VUF11207 | 1378524-41-4 | C27H35FN2O4 |
|
| VER155008抑制剂 | VER155008 | 1134156-31-2 | C25H23Cl2N7O4 |
|
| Uprosertib,GSK2141795抑制剂 | N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide | 1047634-65-0 | C18H16Cl2F2N4O2 |
|
| Tirasemtiv(CK-2017357)抑制剂 | 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one | 1005491-05-3 | C12H14N4O |
|
| TRPM8离子通道激动剂(ICILIN) | 3-(2-hydroxy-phenyl)-6-(3-nitro-phenyl)-3,4-dihydro-1H-pyrimidin-2-one | 36945-98-9 | C16H13N3O4 |
|
| TMC353121;2-[[6-[[[2-(3-羟基丙基)-5-甲基苯基]氨基]甲基]-2-[[3-(吗啉-4-基)丙基]氨基]苯并咪唑-1-基]甲基]-6-甲基吡啶-3-醇 | TMC-353121 | 857066-90-1 | C32H42N6O3 |
|
| TH588抑制剂 | TH588 | 1609960-31-7 | C13H12Cl2N4 |
|
| TH 302; N,N'-双(2-溴乙基)二氨基膦酸 (1-甲基-2-硝基-1H-咪唑-5-基)甲酯 | evofosfamide | 918633-87-1 | C9H16Br2N5O4P |
|
| TEXASRED-X,琥珀酰亚胺酯 | 5-{[(5-carboxypentyl)amino]sulfonyl}-2-(2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-4-ium-9-yl)benzenesulfonate | 199745-67-0 | C37H41N3O8S2 |
|
| TARIQUIDAR二甲磺酸盐六水合物 | Tariquidar (methanesulfonate, hydrate) | 625375-83-9 | C40H52N4O15S2 |
|
| TAK960抑制剂 | TAK-960 | 1137868-52-0 | C27H34F3N7O3 |
|
| Solcitinib抑制剂 | N-[5-[4-(3,3-dimethylazetidine-1-carbonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | 1206163-45-2 | C22H23N5O2 |
|
| SKQ1溴化物 | 2,3-dimethyl-1,4-benzoquinon-5-decyl-triphenylphosphonium bromide | 934826-68-3 | Br*C36H42O2P |
|
| SIRT1抑制剂(INAUHZIN) | 2-((5H-[1,2,4]triazino[5,6-b]indole-3yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one | 309271-94-1 | C25H19N5OS2 |
|
| SD-06; 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑 | 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol | 271576-80-8 | C20H20ClN5O2 |
|
| SB269970盐酸盐 | (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol | 201038-74-6 | C18H28N2O3S |
|
| SB242235;4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶 | 4-(4-fluorophenyl)-5-(2-methoxypyrimidine-4-yl)-1-(piperidine-4-yl)imidazole | 193746-75-7 | C19H20FN5O |
|
| SB1317（TG02）抑制剂 | TG02 | 1204918-72-8 | C23H24N4O |
|
| SB-408124盐酸盐 | SB-408124 Hydrochloride | 1431697-90-3 | C19H19ClF2N4O |
|
| SB 705498; N-(2-溴苯基)-N'-[(3R)-1-[5-(三氟甲基)-2-吡啶基]-3-吡咯烷基]脲 | N-(2-bromophenyl)-N'-[((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl)]urea | 501951-42-4 | C17H16BrF3N4O |
|
| SB 242084双盐酸盐 水合物 | SB 242084 | 181632-25-7 | C21H19ClN4O2 |
|
| S-[(乙酰基氨基)甲基]-N-[芴甲氧羰基]-D-半胱氨酸 | Fmoc-D-Cys(Acm)-OH | 168300-88-7 | C21H22N2O5S |
|
| S-(二苯基甲基)-N-[芴甲氧羰基]-L-半胱氨酸 | Fmoc-Cys(Dpm)-OH | 247595-29-5 | C31H27NO4S |
|
| RO5126766（CH5126766）抑制剂 | VS-6766 | 946128-88-7 | C21H18FN5O5S |
|
| RL人非霍奇金淋巴瘤细胞 | (S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-4-methyl-pentanoic acid | 1188-24-5 | C12H25N5O3 |
|
| RGX-104游离酸 | 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid | 610318-54-2 | C34H33ClF3NO3 |
|
| RET激酶抑制剂(AST487) | AST-487 | 630124-46-8 | C26H30F3N7O2 |
|
| REPERTAXINL-赖氨酸盐 | R(-)-2-(4-isobutylphenyl)propionyl methanesulfonamide L-lysine salt | 266359-93-7 | C6H14N2O2*C14H21NO3S |
|
| REL-N-[5-[4-[5-[[(2R,6S)-2,6-二甲基-4-吗啉基]甲基]-2-恶唑基]-1H-吲唑-6-基]-2-甲氧基-3-吡啶基]甲烷磺酰胺 | N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide | 1254036-66-2 | C24H28N6O5S |
|
| RAF抑制剂(LY3009120) | LY3009120 | 1454682-72-4 | C23H29FN6O |
|
| R7128;(2'R)-2'-去氧-2'-氟-2'-甲基胞苷3',5'-双(2-甲基丙酸)酯 | (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-2-((isobutyryloxy)methyl)-4-methyltetrahydrofuran-3-yl isobutyrate | 940908-79-2 | C18H26FN3O6 |
|
| R-利伐沙班 | 5-R-rivaroxaban | 865479-71-6 | C19H18ClN3O5S |
|
| P游离酸 | 2-[[2-[[2-[[2-[[2-[[5-Amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid | 71977-09-8 | C63H97N17O14S |
|
| PTC-209抑制剂 | PTC-209 | 315704-66-6 | C17H13Br2N5OS |
|
| PKR抑制剂(MITAPIVAT) | N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide | 1260075-17-9 | C24H26N4O3S |
|
| PITOLISANT草酸盐 | pitolisant oxalate | 362665-57-4 | (x)C2H2O4*C17H26ClNO |
|
| PI3K抑制剂(GDC-0032) | taselisib | 1282512-48-4 | C24H28N8O2 |
|
| PI3Kα抑制剂1 | N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide | 1235449-52-1 | C23H25N9O3S |
|
| PI3KΔ抑制剂(ACALISIB) | (S)-2-(1-((9H-purin-6-yl)amino)ethyl)-6-fluoro-3-phenylquinazolin-4(3H)-one | 870281-34-8 | C21H16FN7O |
|
| PHE-GLY 水合物 | (S)-PheGly | 721-90-4 | C11H14N2O3 |
|
| PFK158游离 | PFK158 | 1462249-75-7 | C18H11F3N2O |
|
| PF-38414 | PF-3084014 | 1290543-63-3 | C27H41F2N5O |
|
| PF-3274167抑制剂 | (5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine) | 900510-03-4 | C19H19ClFN5O3 |
|
| PF 8380; 4-[3-氧代-3-(2-氧代-2,3-二氢苯并恶唑-6-基)丙基]哌嗪-1-羧酸 3,5-二氯苄酯 | 3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate | 1144035-53-9 | C22H21Cl2N3O5 |
|
| PEFICITINIB游离态 | Peficitinib | 944134-74-1 | C18H22N4O2 |
|
| PDK1抑制剂 | PS 48 | 1180676-32-7 | C17H15ClO2 |
|
| O型304 | 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide | 1261289-04-6 | C16H11Cl2N3O2S |
|
| Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺 | Orteronel | 566939-85-3 | C18H17N3O2 |
|
| Olcegepant; N-[2-[5-氨基-1(S)-[4-(4-吡啶基)哌嗪-1-甲酰基]戊基氨基]-1(R)-(3,5-二溴-4-羟基苄基)-2-氧代乙基]-4-(2-氧代-1,2,3,4-四氢喹唑啉-3-基)哌啶-1-甲酰胺 | Olcegepant | 204697-65-4 | C38H47Br2N9O5 |
|
| OTSSP167盐酸盐 | OTSSP167 hydrochloride | 1431698-10-0 | C25H29Cl3N4O2 |
|
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