代谢
研究人员通过胃管给三只栗鼠兔喂食了12毫摩尔的叔丁醇。叔丁醇在很大程度上与葡萄糖醛酸结合,并且可以从兔尿中轻易地分离出葡萄糖苷酸;以剂量的百分比来看,24小时内额外排出的葡萄糖醛酸平均为24.4%。研究人员建议,挥发性醇也可能在一定程度上以未改变的状态通过肺部排出。在给予6毫升叔丁醇(途径未指定)的兔呼出的空气中没有检测到醛或酮。
/Researchers/ administered 12 mmol of t-butyl alcohol by stomach tube to three chinchilla rabbits. t-Butyl alcohol was conjugated to a large extent with glucuronic acid, and glucuronides were readily isolated from the rabbit urine; as a percentage of dose, the average extra glucuronic acid excreted over 24 hr was 24.4%. The researchers suggested that volatile alcohols might also be eliminated to some extent in an unchanged state by the lungs. No aldehydes or ketones were detected in the expired air of a rabbit given 6 mL t-butyl alcohol (route unspecified).
来源:Hazardous Substances Data Bank (HSDB)