麦芽三塘水合 | 312693-63-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 麦芽三塘水合
• 英文名称: Maltotriose hydrate
• 英文别名: (2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate
• CAS: 312693-63-3
• 化学式: C18H34O17
• 分子量: 522.5
• InChiKey: HNKASWRMLBJLKJ-HNNWOXMSSA-N

物化性质

• 熔点：
  132-135 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  -8.4
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  270
• 氢给体数：
  12
• 氢受体数：
  17

文献信息

• [EN] TRISACCHARIDE DERIVATES, AND THEIR USE AS ADJUVANTS<br/>[FR] DÉRIVÉS DE TRISACCHARIDE ET LEUR UTILISATION COMME ADJUVANTS
  申请人：IMMUNOVO B V

  公开号：WO2011155822A1

  公开（公告）日：2011-12-15

  The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.

  本发明涉及使用包含替代三糖核的三糖衍生物，该三糖核完全被脂肪酸酯基取代，并且作为辅助剂的可选择地一个或多个阴离子基团，以及用于三糖衍生物本身的三糖衍生物，用于制备此类三糖的方法，用此方法获得的三糖，包含此类三糖衍生物的辅助剂组合物以及包含此类辅助剂组合物的疫苗或工具包。
• Trisaccharide derivates, and their use as adjuvants
  申请人：Immunovo B.V.

  公开号：EP2397484A1

  公开（公告）日：2011-12-21

  The present invention relates to trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to the use of such trisaccharide derivates as adjuvants, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.

  本发明涉及包含取代三糖核的三糖衍生物，所述三糖核完全被脂肪酸酯基团取代，以及可选地一个或多个阴离子基团，以及制备此类三糖的方法，用此方法获得的三糖，将此类三糖衍生物用作佐剂的用途，包括含有此类三糖衍生物的佐剂组合物以及包含此类佐剂组合物的疫苗或工具包。
• Echinocandin/carbohydrate complexes
  申请人：——

  公开号：US20020160942A1

  公开（公告）日：2002-10-31

  A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulations and treatments of fungal infections.

  描述了一种含有碳水化合物的壳聚糖化合物复合物，具有改善的热稳定性和水溶性。还描述了一种制备壳聚糖/碳水化合物复合物的方法，以及在制药配方和治疗真菌感染中使用该复合物的用途。
• ECHINOCANDIN/CARBOHYDRATE COMPLEXES
  申请人：LAREW LARRY A.

  公开号：US20090258820A1

  公开（公告）日：2009-10-15

  A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulations and treatments of fungal infections.

  本文描述了一种含有碳水化合物的棘白菌素化合物复合物，其具有改善的热稳定性和水溶性。本文还描述了制备棘白菌素/碳水化合物复合物的过程，以及在制药配方和治疗真菌感染中使用该复合物的方法。
• TRISACCHARIDE DERIVATIVES, AND THEIR USE AS ADJUVANTS
  申请人：Immunovo B.V.

  公开号：EP3312188A1

  公开（公告）日：2018-04-25

  The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.

  本发明涉及由取代的三糖核心（该三糖核心被脂肪酸酯基团完全取代）和可选的一个或多个阴离子基团组成的三糖衍生物作为佐剂的用途，涉及这种三糖衍生物、制备这种三糖的方法、用这种方法获得的三糖、包含这种三糖衍生物的佐剂组合物以及包含这种佐剂组合物的疫苗或试剂盒。