2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(hydroxyamino)phenyl)propan-2-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: 2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(hydroxyamino)phenyl)propan-2-yl)acetamide
• 英文别名: N-Hydroxy-chloramphenicol；2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-[4-(hydroxyamino)phenyl]propan-2-yl]acetamide
• 化学式: C₁₁H₁₄Cl₂N₂O₄
• 分子量: 309.149
• InChiKey: BLAGYAGCQKHABH-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  101.82
• 氢给体数：
  5.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  氯霉素 在 methyldiazene 作用下， 以 乙腈 为溶剂， 反应 1.5h， 生成 N-((1R,2R)-1-(4-氨基苯基)-1,3-二羟基丙烷-2-基)-2,2-二氯乙酰胺 、 2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(hydroxyamino)phenyl)propan-2-yl)acetamide
  参考文献：
  名称：

  硝基芳烃的选择性光诱导还原为N-芳基羟胺。

  摘要：

  我们报道了选择性光诱导的硝基芳烃还原为N-芳基羟胺。本方法在不存在催化剂或添加剂的情况下促进了这种转化，并且仅使用轻质和甲基肼。这种非催化的光诱导转化具有广泛的范围，优异的官能团耐受性和高收率。该方案的潜力反映了两种通用抗生素阿霉素和氯霉素向生物活性羟胺物种的选择性和直接转化。

  DOI：

  10.1021/acs.orglett.0c01367

文献信息

• N, O Co‐Doping Enhanced Adsorption of Chloramphenicol for Highly Efficient and Robust Electrocatalytic Hydrodechlorination
  作者：Xue‐Feng Cheng、Qiang Cao、Qing Liu、Hao‐Yu Zhang、Qing‐Feng Xu、Jian‐Mei Lu

  DOI：10.1002/cjoc.202400293

  日期：2024.10.15

  Comprehensive SummaryElectrocatalysis technology can effectively promote the hydrodechlorination of chloramphenicol (CAP) to reduce the bio‐toxicity. However, there are still some challenges such as low degradation rate and poor stability. Here, we prepared porous N, O co‐doped carbon supported Pd nanoparticles composites (Pd NPs/NO‐C) for electrocatalytic degradation of CAP. The doping of N and O not only effectively enhanced the interaction between substrate and CAP, promoting the mass transfer process, but also enhanced the anchoring effect on Pd nanoparticles, avoiding the occurrence of aggregation. The prepared composites achieved removal efficiency of CAP over 99% within 1 h, and the rate constant was as high as 6.72 h–1, outperforming previous reported electrocatalysts. Additionally, Pd NPs/NO‐C composites showed a wide range of pH tolerance, excellent ion interference resistance and long‐term stability. Our work unravels the importance of mass transfer processes in solution to electrocatalytic hydrodechlorination and provides new research ideas for catalysts design.