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    首页 分子通 按物质功能分类 医药中间体

    医药中间体

    医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质，它们通常是化学结构较为简单的化合物，通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色，是实现复杂药物分子合成的关键组成部分。

    特点
    1. 多样性：医药中间体种类繁多，根据所需药品的不同而不同。
    2. 复杂性：有些医药中间体本身可能较为简单，但通过一系列复杂的化学反应才能获得最终的药物成品。
    3. 安全性与纯度要求高：在制药行业中，医药中间体的安全性和纯度直接影响到最终产品的质量和效果。
    应用
    1. 合成新药：许多复杂结构的新药都是通过一些简单的中间体经过一系列复杂的化学反应而合成得到的。
    2. 药物改良：通过对现有药物中的某些关键中间体进行优化，可以开发出更有效的治疗手段或者降低副作用。
    3. 原料供应保障：确保医药中间体的稳定供应对于维持药品市场供给至关重要。
    生产与研发

    医药中间体的研发和生产是一个复杂的过程，通常包括以下几个步骤：

    • 合成设计：根据目标药物结构设计合适的合成路线。
    • 实验室规模合成与优化：通过小规模实验来验证并优化反应条件。
    • 中试放大：将实验室中的成功方案应用于工业化生产前的中间试验阶段。
    • 工业化生产：在确保安全性和质量的前提下进行大规模生产。
    发展趋势

    随着化学合成技术的进步和新技术的应用（如绿色化学、计算机辅助设计等），医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时，对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride 874-43-1 C6H10N4*2ClH
    5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride
    —— tert-Butyl (1R,5S,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 419572-18-2 C11H19NO3
    tert-Butyl (1R,5S,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
    —— 2,6-dimethylpiperazine 21655-48-1 C6H14N2
    2,6-dimethylpiperazine
    —— 3-hydroxyestra-1,3,5(10),15-tetraen-17-one 3563-25-5 C18H20O2
    3-hydroxyestra-1,3,5(10),15-tetraen-17-one
    —— (S)-warfarin sodium 5543-79-3 C19H15O4*Na
    (S)-warfarin sodium
    —— 2-amino-3-[2(1H)-quinolinon-4-yl]propionic acid 5162-90-3 C12H12N2O3
    2-amino-3-[2(1H)-quinolinon-4-yl]propionic acid
    —— 2-(5-bromopyridin-3-yl)propan-2-ol 40472-88-6 C8H10BrNO
    2-(5-bromopyridin-3-yl)propan-2-ol
    —— 1-[2-(2-chloro-benzhydryloxy)-ethyl]-4-(2-methyl-benzyl)-piperazine; dihydrochloride 5576-62-5 C27H31ClN2O*2ClH
    1-[2-(2-chloro-benzhydryloxy)-ethyl]-4-(2-methyl-benzyl)-piperazine; dihydrochloride
    —— N-tosyl-trans-4-hydroxy-L-proline 20275-18-7 C12H15NO5S
    N-tosyl-trans-4-hydroxy-L-proline
    —— 5'-O-dimethoxytrityl-5-trifluoroethoxycarbonyl-2'-deoxyuridine 186553-11-7 C33H31F3N2O9
    5'-O-dimethoxytrityl-5-trifluoroethoxycarbonyl-2'-deoxyuridine
    —— N,N-DIMETHYL-4,4'-AZODIANILINE 539-17-3 C14H16N4
    N,N-DIMETHYL-4,4'-AZODIANILINE
    —— bis(2-bromophenyl)sulfide 21848-84-0 C12H8Br2S
    bis(2-bromophenyl)sulfide
    —— NSC 177223 36707-00-3 C13H15N5O6
    NSC 177223
    —— 7-oxabicyclo<2.2.1>heptene-exo-2,3-dicarboxylic anhydride 6766-44-5 C8H6O4
    7-oxabicyclo<2.2.1>heptene-exo-2,3-dicarboxylic anhydride
    —— Cbz-Pro-Pro-OH 7360-23-8 C18H22N2O5
    Cbz-Pro-Pro-OH
    —— 3'-O-methoxyethyladenosine 303197-30-0 C13H19N5O5
    3'-O-methoxyethyladenosine
    —— 3,4-dihydro-8-hydroxy-3-nitroxy-2H-1-benzopyran 81486-20-6 C9H9NO5
    3,4-dihydro-8-hydroxy-3-nitroxy-2H-1-benzopyran
    —— 6-(bromomethyl)-6'-methyl-2,2'-bipyridine 96517-98-5 C12H11BrN2
    6-(bromomethyl)-6'-methyl-2,2'-bipyridine
    —— S-benzothiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(syn-methoxyimino)thioacetate 80756-85-0 C13H10N4O2S3
    S-benzothiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(syn-methoxyimino)thioacetate
    —— 1-(3-chloropropyl)-4-methylpiperazine dihydrochloride 2031-23-4 C8H17ClN2*2ClH
    1-(3-chloropropyl)-4-methylpiperazine dihydrochloride
    —— 2-diphenylaminothiophene 174904-78-0 C16H13NS
    2-diphenylaminothiophene
    —— [cis-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl] 4-methyl-benzenesulfonate 134071-44-6 C21H20Cl2N2O5S
    [cis-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl] 4-methyl-benzenesulfonate
    —— (6-chloro-pyridazin-3-ylsulfanyl)-acetic acid 69827-43-6 C6H5ClN2O2S
    (6-chloro-pyridazin-3-ylsulfanyl)-acetic acid
    —— tert-butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate 317354-91-9 C10H17F2NO3
    tert-butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate
    —— N-[3-[3-(dimethylamine)-1-oxo-2-propenyl]phenyl]-N-ethyl-acetamide 1227694-96-3 C15H20N2O2
    N-[3-[3-(dimethylamine)-1-oxo-2-propenyl]phenyl]-N-ethyl-acetamide
    —— 4,5-Diamino-6-hydroxypyrimidine sulphate 52502-66-6 C4H6N4O*H2O4S
    4,5-Diamino-6-hydroxypyrimidine sulphate
    —— 9-amino-1,2,3,4,5,6,7,8-octahydroacridine 13415-07-1 C13H18N2
    9-amino-1,2,3,4,5,6,7,8-octahydroacridine
    —— 2-acetamido-2,4-dideoxy-4-fluoro-α,β-D-glucopyranose 129728-87-6 C8H14FNO5
    2-acetamido-2,4-dideoxy-4-fluoro-α,β-D-glucopyranose
    —— (-)-trans-4-(S)-(pyrid-4-yl)-2-(4-nitrophenyl)-2-oxo-1,3,2-dioxaphosphorinane 685111-88-0 C14H13N2O6P
    (-)-trans-4-(S)-(pyrid-4-yl)-2-(4-nitrophenyl)-2-oxo-1,3,2-dioxaphosphorinane
    —— N'-[4-[[(aminoiminomethyl)thio]methyl]-2-thiazolyl]-guanidine dihydrochloride 88046-01-9 C6H10N6S2*2ClH
    N'-[4-[[(aminoiminomethyl)thio]methyl]-2-thiazolyl]-guanidine dihydrochloride
    —— N,N-dimethyl-N'-(3-methylpyridyl)formamidine 36172-55-1 C9H13N3
    N,N-dimethyl-N'-(3-methylpyridyl)formamidine
    —— ethyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate 6286-56-2 C14H12N2O2
    ethyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate
    —— 3-(2-nitroprop-1-en-1-yl)-1H-indole 22693-51-2 C11H10N2O2
    3-(2-nitroprop-1-en-1-yl)-1H-indole
    —— SR 95533 66548-69-4 C13H9F3N4
    SR 95533
    —— 5-chloro-1,1,1-trimethoxypentane 23249-97-0 C8H17ClO3
    5-chloro-1,1,1-trimethoxypentane
    —— ethyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate 808116-52-1 C18H15NO4
    ethyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
    —— 19-nor-5β-androstane-3,17-dione 5696-51-5 C18H26O2
    19-nor-5β-androstane-3,17-dione
    —— 4-(1H-indol-1-yl)aniline 938018-12-3 C14H12N2
    4-(1H-indol-1-yl)aniline
    —— 9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one 80049-87-2 C10H11FN4O4
    9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
    —— 1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate 869567-97-5 C24H25BrN2O5
    1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate
    —— 5-iodo-2'-deoxy-2'-fluorouridine 55612-21-0 C9H10FIN2O5
    5-iodo-2'-deoxy-2'-fluorouridine
    —— N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine,Dihydrochloride 5330-29-0 C21H33N3O*2ClH
    N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine,Dihydrochloride
    —— 5-bromo-6-chloroisocytosine 55740-64-2 C4H3BrClN3O
    5-bromo-6-chloroisocytosine
    —— trans-[2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate 61397-56-6 C18H15BrCl2O4
    trans-[2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate
    —— (+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate 61397-56-6 C18H15BrCl2O4
    (+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate
    —— sulfachloropyridazine sodium 23282-55-5 C10H8ClN4O2S*Na
    sulfachloropyridazine sodium
    —— 1-phenyl-2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate 89346-82-7 C22H30O7S
    1-phenyl-2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate
    —— 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid 28416-82-2 C21H26F2O5
    6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
    —— 2-(4-{[(3-trifluoromethylphenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid 634175-34-1 C22H21F3N6O3S
    2-(4-{[(3-trifluoromethylphenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
    —— ethyl 5-chloro-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate 75020-42-7 C13H14ClN3O3
    ethyl 5-chloro-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate