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    首页 分子通 按物质功能分类 医药中间体

    医药中间体

    医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质，它们通常是化学结构较为简单的化合物，通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色，是实现复杂药物分子合成的关键组成部分。

    特点
    1. 多样性：医药中间体种类繁多，根据所需药品的不同而不同。
    2. 复杂性：有些医药中间体本身可能较为简单，但通过一系列复杂的化学反应才能获得最终的药物成品。
    3. 安全性与纯度要求高：在制药行业中，医药中间体的安全性和纯度直接影响到最终产品的质量和效果。
    应用
    1. 合成新药：许多复杂结构的新药都是通过一些简单的中间体经过一系列复杂的化学反应而合成得到的。
    2. 药物改良：通过对现有药物中的某些关键中间体进行优化，可以开发出更有效的治疗手段或者降低副作用。
    3. 原料供应保障：确保医药中间体的稳定供应对于维持药品市场供给至关重要。
    生产与研发

    医药中间体的研发和生产是一个复杂的过程，通常包括以下几个步骤：

    • 合成设计：根据目标药物结构设计合适的合成路线。
    • 实验室规模合成与优化：通过小规模实验来验证并优化反应条件。
    • 中试放大：将实验室中的成功方案应用于工业化生产前的中间试验阶段。
    • 工业化生产：在确保安全性和质量的前提下进行大规模生产。
    发展趋势

    随着化学合成技术的进步和新技术的应用（如绿色化学、计算机辅助设计等），医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时，对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5,5-dimethyl-oxazolidin-2-one 1121-83-1 C5H9NO2
    5,5-dimethyl-oxazolidin-2-one
    —— 1,3-dimethyl-3-(tosylmethyl)indolin-2-one 1446402-55-6 C18H19NO3S
    1,3-dimethyl-3-(tosylmethyl)indolin-2-one
    —— 2-benzylquinuclidin-3-amine 40615-00-7 C14H20N2
    2-benzylquinuclidin-3-amine
    —— Butanoic acid, 2-(hydroxyimino)-3-oxo-, ethyl ester 5408-04-8 C6H9NO4
    Butanoic acid, 2-(hydroxyimino)-3-oxo-, ethyl ester
    —— benzyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate 206265-31-8 C16H25NO6
    benzyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate
    —— U 75302 119477-85-9 C22H35NO3
    U 75302
    —— 6-iodouridine 105967-11-1 C9H11IN2O6
    6-iodouridine
    —— (2S,3S,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate 1018899-03-0 C27H31ClO8S
    (2S,3S,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate
    —— 1,6,7,12-tetrabromoperylene-3,4,9,10-tetracarboxylic acid bisanhydride 321945-85-1 C24H4Br4O6
    1,6,7,12-tetrabromoperylene-3,4,9,10-tetracarboxylic acid bisanhydride
    —— ethyl 2-amino-5-cyano-4-methylthiophene-3-carboxylate 43028-74-6 C9H10N2O2S
    ethyl 2-amino-5-cyano-4-methylthiophene-3-carboxylate
    —— 2,3-pyrazinedithiol 80458-31-7 C4H4N2S2
    2,3-pyrazinedithiol
    —— <i>N</i>,<i>N</i>-phthaloyl-<i>DL</i>-glutamic acid-5-benzyl ester 88784-33-2 C20H17NO6
    <i>N</i>,<i>N</i>-phthaloyl-<i>DL</i>-glutamic acid-5-benzyl ester
    —— 4-(5-chloro-2-hydroxy-phenylazo)-resorcinol 4867-01-0 C12H9ClN2O3
    4-(5-chloro-2-hydroxy-phenylazo)-resorcinol
    —— 2-(piperidin-1-yl)quinoline-6-carboxylic acid 958333-20-5 C15H16N2O2
    2-(piperidin-1-yl)quinoline-6-carboxylic acid
    —— (Z)-2-(but-2-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 91890-00-5 C10H19BO2
    (Z)-2-(but-2-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
    —— methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate 1017273-31-2 C10H9NO4
    methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate
    —— tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate 632352-74-0 C16H20FNO3
    tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate
    —— tubulysin B 205304-87-6 C42H63N5O10S
    tubulysin B
    —— 3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl acetate 68733-19-7 C14H19N3O9
    3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl acetate
    —— 4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid 1818393-16-6 C34H38Cl2FN3O4
    4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid
    —— (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid 1207755-38-1 C38H65NO5
    (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid
    —— 1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine 13314-69-7 C19H21NO
    1-benzyl-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine
    —— Bulbocapnine methyl ether 2490-83-7 C20H21NO4
    Bulbocapnine methyl ether
    —— 5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline 215788-34-4 C10H10F3N
    5-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline
    —— 2-{2-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-thiazol-5-yl}-propan-2-ol 225382-67-2 C22H20N4OS2
    2-{2-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-thiazol-5-yl}-propan-2-ol
    —— (R)-4-((S)-1-(benzyloxy)but-3-ene-1-yl)-2,2-dimethyl-1,3-dioxypentane 87604-53-3 C16H22O3
    (R)-4-((S)-1-(benzyloxy)but-3-ene-1-yl)-2,2-dimethyl-1,3-dioxypentane
    —— gepotidacin 1075236-89-3 C24H28N6O3
    gepotidacin
    —— 2-furyloxirane 2745-17-7 C6H6O2
    2-furyloxirane
    —— N-desmethyl sildenafil 139755-82-1 C21H28N6O4S
    N-desmethyl sildenafil
    —— 4-methanesulfonyl-2,2,6,6-tetramethyl-1-piperidinyloxy radical 35203-66-8 C10H20NO4S
    4-methanesulfonyl-2,2,6,6-tetramethyl-1-piperidinyloxy radical
    —— 4-methyl-7-nitro-2H-chromen-2-one 179897-88-2 C10H7NO4
    4-methyl-7-nitro-2H-chromen-2-one
    —— (E)-3-(2-nitroprop-1-en-1-yl)thiophene 149977-36-6 C7H7NO2S
    (E)-3-(2-nitroprop-1-en-1-yl)thiophene
    —— 3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate 1101120-00-6 C12H12N2O4
    3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate
    —— thiophene-3-carbaldehyde oxime 42466-50-2 C5H5NOS
    thiophene-3-carbaldehyde oxime
    —— Cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate 67914-86-7 C14H15Cl2N3O5S
    Cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
    —— 2-amino-5-S-dibenzylamino-4-oxo-1,6-diphenylhex-2-ene 156732-13-7 C32H32N2O
    2-amino-5-S-dibenzylamino-4-oxo-1,6-diphenylhex-2-ene
    —— [3-(4-tert-butoxycarbonylaminophenyl)-2-oxopropyl]phosphonic acid dimethyl ester 494224-44-1 C16H24NO6P
    [3-(4-tert-butoxycarbonylaminophenyl)-2-oxopropyl]phosphonic acid dimethyl ester
    —— furo[3,2-d]pyrimidin-4(3H)-one 655255-08-6 C6H4N2O2
    furo[3,2-d]pyrimidin-4(3H)-one
    —— tert-butyl 2-carbamoyl-1H-pyrrol-1-ylcarbamate 1206824-76-1 C10H15N3O3
    tert-butyl 2-carbamoyl-1H-pyrrol-1-ylcarbamate
    —— 6-amino-7-fluoro-5H-benzoimidazole-5-carboxylic acid methyl ester 918321-29-6 C9H8FN3O2
    6-amino-7-fluoro-5H-benzoimidazole-5-carboxylic acid methyl ester
    —— 6-methoxybenzoxazole 114980-26-6 C8H7NO2
    6-methoxybenzoxazole
    —— ethyl 5-bromoisoquinoline-1-carboxylate 1111311-65-9 C12H10BrNO2
    ethyl 5-bromoisoquinoline-1-carboxylate
    —— 3,5-dichloro-4-((6-chloropyridazin-3-yl)oxy)aniline 1581304-46-2 C10H6Cl3N3O
    3,5-dichloro-4-((6-chloropyridazin-3-yl)oxy)aniline
    —— N-(3,5-dichloro-4-((6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)benzamide 1581304-48-4 C17H11Cl2N3O3
    N-(3,5-dichloro-4-((6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)benzamide
    —— N-(9-fuorenylmethoxycarbonyl)-(2S,4R)-4-methylproline 333777-34-7 C21H21NO4
    N-(9-fuorenylmethoxycarbonyl)-(2S,4R)-4-methylproline
    —— bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether 63910-63-4 C10H12N6O5
    bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether
    —— 1-(4-pyridyl)-2-(4-bromophenyl)ethylene 42834-34-4 C13H10BrN
    1-(4-pyridyl)-2-(4-bromophenyl)ethylene
    —— (2S,5R)-(1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 147126-73-6 C18H27N3O4S
    (2S,5R)-(1R,2S,5S)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate
    —— (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid L-lysine 928821-41-4 C6H14N2O2*C21H23F3O5S
    (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid L-lysine
    —— 3-bromo-9H-pyrido[2,3-b]indole 1428799-40-9 C11H7BrN2
    3-bromo-9H-pyrido[2,3-b]indole