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    首页 分子通 按物质功能分类 医药中间体

    医药中间体

    医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质，它们通常是化学结构较为简单的化合物，通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色，是实现复杂药物分子合成的关键组成部分。

    特点
    1. 多样性：医药中间体种类繁多，根据所需药品的不同而不同。
    2. 复杂性：有些医药中间体本身可能较为简单，但通过一系列复杂的化学反应才能获得最终的药物成品。
    3. 安全性与纯度要求高：在制药行业中，医药中间体的安全性和纯度直接影响到最终产品的质量和效果。
    应用
    1. 合成新药：许多复杂结构的新药都是通过一些简单的中间体经过一系列复杂的化学反应而合成得到的。
    2. 药物改良：通过对现有药物中的某些关键中间体进行优化，可以开发出更有效的治疗手段或者降低副作用。
    3. 原料供应保障：确保医药中间体的稳定供应对于维持药品市场供给至关重要。
    生产与研发

    医药中间体的研发和生产是一个复杂的过程，通常包括以下几个步骤：

    • 合成设计：根据目标药物结构设计合适的合成路线。
    • 实验室规模合成与优化：通过小规模实验来验证并优化反应条件。
    • 中试放大：将实验室中的成功方案应用于工业化生产前的中间试验阶段。
    • 工业化生产：在确保安全性和质量的前提下进行大规模生产。
    发展趋势

    随着化学合成技术的进步和新技术的应用（如绿色化学、计算机辅助设计等），医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时，对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-chloro-2-cyclopropyl-1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid 858956-26-0 C8H7ClN2O3
    5-chloro-2-cyclopropyl-1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acid
    —— 6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2(1H)-one 22123-11-1 C10H6F3NOS
    6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2(1H)-one
    —— Cytidine, 2'-deoxy-5-fluoro- 10356-76-0 C9H12FN3O4
    Cytidine, 2'-deoxy-5-fluoro-
    —— 2-fluoro-4-methoxy-1-(trifluoromethyl)benzene 1214344-33-8 C8H6F4O
    2-fluoro-4-methoxy-1-(trifluoromethyl)benzene
    —— 3-iodo-1-(phenylsulfonyl)-1H-indole-7-carbonitrile 96631-87-7 C15H9IN2O2S
    3-iodo-1-(phenylsulfonyl)-1H-indole-7-carbonitrile
    —— (-)-Tabernemontanine 2134-98-7 C21H26N2O3
    (-)-Tabernemontanine
    —— 2-Fluoro-9-(2,3,5-tri-o-acetylpentofuranosyl)-9h-purin-6-amine 15811-32-2 C16H18FN5O7
    2-Fluoro-9-(2,3,5-tri-o-acetylpentofuranosyl)-9h-purin-6-amine
    —— 1,2:3,4-Di-O-isopropylidene-6-deoxy-6-tosyl-alpha-D-galactopyranose 4478-43-7 C19H26O8S
    1,2:3,4-Di-O-isopropylidene-6-deoxy-6-tosyl-alpha-D-galactopyranose
    —— 6-amino-2-mercapto-3H-pyrimidin-4-one monohydrate 65802-56-4 C4H7N3O2S
    6-amino-2-mercapto-3H-pyrimidin-4-one monohydrate
    —— 3,5-Bis-o-(4-chlorobenzoyl)-2-deoxypentofuranosyl chloride 21740-23-8 C19H15Cl3O5
    3,5-Bis-o-(4-chlorobenzoyl)-2-deoxypentofuranosyl chloride
    —— 1-(4-carboxyphenyl)-3-methyl-5-pyrazolone 60875-16-3 C11H10N2O3
    1-(4-carboxyphenyl)-3-methyl-5-pyrazolone
    —— 4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide 36707-00-3 C13H15N5O6
    4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
    —— (-)-methyl (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-amino-2-hydroxycyclopentanecarboxylate 229615-05-8 C15H28N2O4
    (-)-methyl (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-amino-2-hydroxycyclopentanecarboxylate
    —— 2,3,4,6-tetra-O-benzyl-1-C-(dichloromethyl)-D-glucopyranose 140658-50-0 C35H36Cl2O6
    2,3,4,6-tetra-O-benzyl-1-C-(dichloromethyl)-D-glucopyranose
    —— ethyl 4-oxo-1H-1,10-phenanthroline-3-carboxylate 49590-04-7 C15H12N2O3
    ethyl 4-oxo-1H-1,10-phenanthroline-3-carboxylate
    —— 5-anilino-2-hydroxy-penta-2,4-dienal-phenylimine; hydrochloride 17315-76-3 C17H16N2O*ClH
    5-anilino-2-hydroxy-penta-2,4-dienal-phenylimine; hydrochloride
    —— 4-Amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxypyrimidin-2-one 37805-90-6 C10H15N3O6
    4-Amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxypyrimidin-2-one
    —— 2'-Chlor-2'-desoxy-Ψ-uridin 4753-04-2 C9H11ClN2O5
    2'-Chlor-2'-desoxy-Ψ-uridin
    —— (S)-methyl-N-(1-phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate 130194-96-6 C16H19NO2
    (S)-methyl-N-(1-phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate
    —— Ethyl 3-(quinolin-4-YL)prop-2-enoate 69976-10-9 C14H13NO2
    Ethyl 3-(quinolin-4-YL)prop-2-enoate
    —— (2R,3S,4R,5R,6S)-5-amino-6-[(2R,4R,5R)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)oxane-3,4-diol 78341-33-0 C18H35N3O13
    (2R,3S,4R,5R,6S)-5-amino-6-[(2R,4R,5R)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)oxane-3,4-diol
    —— 4-[(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol 524-63-0 C19H22N2O2
    4-[(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol
    —— (+)-1-phenyl-1-[2]pyridyl-ethanol 19490-92-7 C13H13NO
    (+)-1-phenyl-1-[2]pyridyl-ethanol
    —— 2-(3-isopropylphenyl)pyridine 1314921-39-5 C14H15N
    2-(3-isopropylphenyl)pyridine
    —— (3R,6R)-6-[(1R,3aS,7aR)-4-[2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol 55721-11-4 C27H44O3
    (3R,6R)-6-[(1R,3aS,7aR)-4-[2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
    —— 2',3'-dideoxy-N6-benzoyl-adenosine 77244-86-1 C17H17N5O3
    2',3'-dideoxy-N6-benzoyl-adenosine
    —— ethyl 5-oxo-2H-1,2-oxazole-3-carboxylate 88393-81-1 C6H7NO4
    ethyl 5-oxo-2H-1,2-oxazole-3-carboxylate
    —— 3-Amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide 40127-89-7 C6H5ClN4O
    3-Amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide
    —— Clicoemodin 34298-85-6 C21H20O10
    Clicoemodin
    —— 4-[(S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol 524-63-0 C19H22N2O2
    4-[(S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol
    —— 6-(α-Styryl)pyridazin-3(2H)-one 83516-65-8 C12H10N2O
    6-(α-Styryl)pyridazin-3(2H)-one
    —— cis-1-Methyl-2-<2-(2-thienyl)vinyl)>-Δ<sup>2</sup>-tetrahydropyrimidin-tartrat 21573-92-2 C4H6O6*C11H14N2S
    cis-1-Methyl-2-<2-(2-thienyl)vinyl)>-Δ<sup>2</sup>-tetrahydropyrimidin-tartrat
    —— (5R)-1-benzyl-5-ethoxyimidazolidine-2,4-dione 65855-02-9 C12H14N2O3
    (5R)-1-benzyl-5-ethoxyimidazolidine-2,4-dione
    —— 6-bromobenzothiazole-2-carbaldehyde 53218-26-1 C8H4BrNOS
    6-bromobenzothiazole-2-carbaldehyde
    —— 4-(4-bromo-1H-pyrazol-1-yl)benzoic acid 926212-84-2 C10H7BrN2O2
    4-(4-bromo-1H-pyrazol-1-yl)benzoic acid
    —— (Z)-N,N-Dimethyl-4-(2-(quinolin-4-yl)vinyl)aniline 897-55-2 C19H18N2
    (Z)-N,N-Dimethyl-4-(2-(quinolin-4-yl)vinyl)aniline
    —— dimethyl diazomethylphosphonate 27491-70-9 C3H8N2O3P
    dimethyl diazomethylphosphonate
    —— 6,7-dichloro-1H-indole-2-carboxylic acid 383132-13-6 C9H5Cl2NO2
    6,7-dichloro-1H-indole-2-carboxylic acid
    —— 1-Methyl-6-oxo-pyridazine-3-carboxylate 100047-66-3 C6H5N2O3-
    1-Methyl-6-oxo-pyridazine-3-carboxylate
    —— 3-Azatricyclo<3.2.1.0<sup>2,4exo</sup>>-octan 279-82-3 C7H13N
    3-Azatricyclo<3.2.1.0<sup>2,4exo</sup>>-octan
    —— Phytonadione epoxide, (E,2S,3R)- 25486-55-9 C31H46O3
    Phytonadione epoxide, (E,2S,3R)-
    —— 2,3,4,6-tetra-O-benzyl-L-idopyranose 4132-28-9 C34H36O6
    2,3,4,6-tetra-O-benzyl-L-idopyranose
    —— Tetra-O-benzyl-D-galactopyranose 4132-28-9 C34H36O6
    Tetra-O-benzyl-D-galactopyranose
    —— (5R)-5-aminopiperidin-2-one 1002566-99-5 C5H10N2O
    (5R)-5-aminopiperidin-2-one
    —— 1,2-dihydro-2-oxo-6-(2-pyridyl)-3-pyridinecarbonitrile 56304-74-6 C11H7N3O
    1,2-dihydro-2-oxo-6-(2-pyridyl)-3-pyridinecarbonitrile
    —— 6-bromo-quinoxalin-2-ylamine 1071605-38-3 C8H6BrN3
    6-bromo-quinoxalin-2-ylamine
    —— 2-Cyano-3-pyridin-3-ylprop-2-enoic acid 103029-74-9 C9H6N2O2
    2-Cyano-3-pyridin-3-ylprop-2-enoic acid
    —— (E)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetic acid 75028-24-9 C6H8N4O3S
    (E)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetic acid
    —— 7-Methylamino-4-trifluoromethyl-chromen-2-one 53518-14-2 C11H8F3NO2
    7-Methylamino-4-trifluoromethyl-chromen-2-one
    —— Methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate 175203-39-1 C10H6F3NO3S
    Methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate