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    首页 分子通 按物质功能分类 医药中间体

    医药中间体

    医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质，它们通常是化学结构较为简单的化合物，通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色，是实现复杂药物分子合成的关键组成部分。

    特点
    1. 多样性：医药中间体种类繁多，根据所需药品的不同而不同。
    2. 复杂性：有些医药中间体本身可能较为简单，但通过一系列复杂的化学反应才能获得最终的药物成品。
    3. 安全性与纯度要求高：在制药行业中，医药中间体的安全性和纯度直接影响到最终产品的质量和效果。
    应用
    1. 合成新药：许多复杂结构的新药都是通过一些简单的中间体经过一系列复杂的化学反应而合成得到的。
    2. 药物改良：通过对现有药物中的某些关键中间体进行优化，可以开发出更有效的治疗手段或者降低副作用。
    3. 原料供应保障：确保医药中间体的稳定供应对于维持药品市场供给至关重要。
    生产与研发

    医药中间体的研发和生产是一个复杂的过程，通常包括以下几个步骤：

    • 合成设计：根据目标药物结构设计合适的合成路线。
    • 实验室规模合成与优化：通过小规模实验来验证并优化反应条件。
    • 中试放大：将实验室中的成功方案应用于工业化生产前的中间试验阶段。
    • 工业化生产：在确保安全性和质量的前提下进行大规模生产。
    发展趋势

    随着化学合成技术的进步和新技术的应用（如绿色化学、计算机辅助设计等），医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时，对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— Olaflur 6818-37-7 C27H58N2O3*2FH
    Olaflur
    —— 3-Phenylhexahydro-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrilium 88056-92-2 C14H17N2O+
    3-Phenylhexahydro-5H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrilium
    —— 3,4-Dihydro-2H-1-benzopyran-4-aminium 53981-38-7 C9H12NO+
    3,4-Dihydro-2H-1-benzopyran-4-aminium
    —— 3-{[tert-Butoxy(hydroxy)methylidene]amino}pyrrolidin-1-ium 99724-19-3 C9H19N2O2+
    3-{[tert-Butoxy(hydroxy)methylidene]amino}pyrrolidin-1-ium
    —— 4-(Oxolane-2-carbonyl)piperazin-1-ium 63074-07-7 C9H17N2O2+
    4-(Oxolane-2-carbonyl)piperazin-1-ium
    —— 5-bromo-6-chloro-1H-indol-3-yl phosphate 6769-80-8 C8H4BrClNO4P-2
    5-bromo-6-chloro-1H-indol-3-yl phosphate
    —— 3-Methylpyridine-4-carboxylate 4021-12-9 C7H6NO2-
    3-Methylpyridine-4-carboxylate
    —— [(2-Oxo-2H-1-benzopyran-7-yl)oxy]acetate 126424-85-9 C11H7O5-
    [(2-Oxo-2H-1-benzopyran-7-yl)oxy]acetate
    —— (3R)-3-hydroxy-3-phenylpropanoate 2768-42-5 C9H9O3-
    (3R)-3-hydroxy-3-phenylpropanoate
    —— 1,4-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester 10314-98-4 C14H16NO4-
    1,4-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester
    —— 3-Cyano-4-(ethoxycarbonyl)-6-methylpyridine-2-thiolate 56891-69-1 C10H9N2O2S-
    3-Cyano-4-(ethoxycarbonyl)-6-methylpyridine-2-thiolate
    —— 4-Azaniumyl-1,2,2,6,6-pentamethylpiperidin-1-ium 40327-96-6 C10H24N2+2
    4-Azaniumyl-1,2,2,6,6-pentamethylpiperidin-1-ium
    —— 1H-indole-6-carboxylate 1670-82-2 C9H6NO2-
    1H-indole-6-carboxylate
    —— 3-[(tert-Butylimino)(hydroxy)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium 149182-72-9 C14H21N2O+
    3-[(tert-Butylimino)(hydroxy)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium
    —— 4-(2,3-Dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-ium 70918-00-2 C13H17N2O3+
    4-(2,3-Dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-ium
    —— 4,4-dicarboxylato-2,2'-bipyridine(2-) 6813-38-3 C12H6N2O4
    4,4-dicarboxylato-2,2'-bipyridine(2-)
    —— Decahydroquinolin-7-ol 90949-78-3 C9H17NO
    Decahydroquinolin-7-ol
    —— Iliren 71116-82-0 C20H28O6S
    Iliren
    —— 2,4,5-Triamino-6-pyrimidinol dihydrochloride 51324-37-9 C4H9Cl2N5O
    2,4,5-Triamino-6-pyrimidinol dihydrochloride
    —— (2R,5R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol 4132-28-9 C34H36O6
    (2R,5R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol
    —— 1H-5-Mercapto-1,2,3-triazole sodium salt dihydrate 59032-27-8 C2H6N3NaO2S
    1H-5-Mercapto-1,2,3-triazole sodium salt dihydrate
    —— Taurochenodeoxycholic acid sodium 6009-98-9 C26H45NNaO6S
    Taurochenodeoxycholic acid sodium
    —— <i>meso</i>-1,4-bis-tetrahydropyran-2-yloxy-benzene 2139-44-8 C16H22O4
    <i>meso</i>-1,4-bis-tetrahydropyran-2-yloxy-benzene
    —— 2-Isopropoxy-5-methyl-4-(piperidin-4-yl)aniline dihydrochloride 1380575-45-0 C15H26Cl2N2O
    2-Isopropoxy-5-methyl-4-(piperidin-4-yl)aniline dihydrochloride
    —— Nicotinamide hypoxanthine dinucleotide phosphate reduced tetrasodium salt 42934-87-2 C21H25N6Na4O18P3
    Nicotinamide hypoxanthine dinucleotide phosphate reduced tetrasodium salt
    —— (1R,3S)-5-[2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol 103909-75-7 C26H42O4
    (1R,3S)-5-[2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
    —— Pge2,16,16-dimethyl 39746-25-3 C22H36O5
    Pge2,16,16-dimethyl
    —— Pyrazine-2,5-dicarboxylate 205692-63-3 C6H2N2O4-2
    Pyrazine-2,5-dicarboxylate
    —— 3-[(2,4-diphenyl-4H-chromen-3-yl)methylideneamino]-6,7-dimethoxy-2-methyl-quinazolin-4-one 4891-44-5 C33H27N3O4
    3-[(2,4-diphenyl-4H-chromen-3-yl)methylideneamino]-6,7-dimethoxy-2-methyl-quinazolin-4-one
    —— 3,3-Dimethyl-1-{[5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}butan-2-one 5315-73-1 C18H18N2O2S
    3,3-Dimethyl-1-{[5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}butan-2-one
    —— 4-[[4-(Diethylamino)phenyl]azo]-1-[(4-nitrophenyl)methyl]pyridinium bromide 75902-86-2 C22H24N5O2+
    4-[[4-(Diethylamino)phenyl]azo]-1-[(4-nitrophenyl)methyl]pyridinium bromide
    —— 5,10,15,20-Tetrapyridin-2-yl-21,22-dihydroporphyrin 40904-90-3 C40H26N8
    5,10,15,20-Tetrapyridin-2-yl-21,22-dihydroporphyrin
    —— 2-Amino-5-hydroxy-6-methyl-4-pyrimidone 14405-13-1 C5H7N3O2
    2-Amino-5-hydroxy-6-methyl-4-pyrimidone
    —— Chelidonate 6003-94-7 C7H2O6-2
    Chelidonate
    —— 3-Pyridylacetate 6419-36-9 C7H6NO2-
    3-Pyridylacetate
    —— 2-(Furan-2-yl)quinoline-4-carboxylate 20146-25-2 C14H8NO3-
    2-(Furan-2-yl)quinoline-4-carboxylate
    —— Holmium;4-hydroxypent-3-en-2-one 14589-33-4 C15H24HoO6
    Holmium;4-hydroxypent-3-en-2-one
    —— 6-Fluoro-2-methylamino-pyrimidin-4-ol 313961-68-1 C5H6FN3O
    6-Fluoro-2-methylamino-pyrimidin-4-ol
    —— 6-(Methoxymethyl)-2-(pyridin-3-YL)pyrimidin-4-OL 339278-99-8 C11H11N3O2
    6-(Methoxymethyl)-2-(pyridin-3-YL)pyrimidin-4-OL
    —— <i>racem.</i>-1,4-bis-tetrahydropyran-2-yloxy-benzene 2139-44-8 C16H22O4
    <i>racem.</i>-1,4-bis-tetrahydropyran-2-yloxy-benzene
    —— 2-(Pyridin-2-yl)quinoline-4-carboxylate 57882-27-6 C15H9N2O2-
    2-(Pyridin-2-yl)quinoline-4-carboxylate
    —— 2-(4-Methylphenyl)quinoline-4-carboxylate 20389-05-3 C17H12NO2-
    2-(4-Methylphenyl)quinoline-4-carboxylate
    —— 6-(1-formyl-2-hydroxyvinyl)pyridine-3-carboxylic acid 180615-36-5 C9H7NO4
    6-(1-formyl-2-hydroxyvinyl)pyridine-3-carboxylic acid
    —— 2-(Diisopropylsilyl)pyridine 1232692-92-0 C11H18NSi
    2-(Diisopropylsilyl)pyridine
    —— 4-Piperidinobenzoate 22090-24-0 C12H14NO2-
    4-Piperidinobenzoate
    —— 4-Amino-2-dimethylamino-6-hydroxypyrimidine hemihydrate 76750-84-0 C6H12N4O2
    4-Amino-2-dimethylamino-6-hydroxypyrimidine hemihydrate
    —— 7-[(1R,2R,3R)-3-hydroxy-2-[(3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]-5-heptenoic acid 39746-25-3 C22H36O5
    7-[(1R,2R,3R)-3-hydroxy-2-[(3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]-5-heptenoic acid
    —— Ethyl (2R,3aR,10Z,11aS,12aR,14aR)-2-{[2-(4-isopropyl-1,3-thiazol-2-yl)-7-methoxy-8-methyl-4-quinolinyl]oxy}-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cycloprop a[g][1,6]diazacyclotetradecine-12a(1H)-carboxylate 923604-57-3 C37H46N4O6S
    Ethyl (2R,3aR,10Z,11aS,12aR,14aR)-2-{[2-(4-isopropyl-1,3-thiazol-2-yl)-7-methoxy-8-methyl-4-quinolinyl]oxy}-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cycloprop a[g][1,6]diazacyclotetradecine-12a(1H)-carboxylate
    —— gadolinium(3+);2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid 72573-82-1 C16H28GdN4O8+3
    gadolinium(3+);2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
    —— Sodium 4-(nicotinamido)butanoate 62936-56-5 C10H11N2NaO3
    Sodium 4-(nicotinamido)butanoate