摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词
历史搜索
    热门化合物HOT
    • 喹啉
    • 水杨醛
    • 二溴甲烷
    • 谷胱甘肽
    • L-乳酸
    • 苯巴比妥
    • 辣椒碱
    • 非那明
    • 百草枯
    • 联苯烯
    首页 分子通 按物质功能分类 医药中间体

    医药中间体

    医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质，它们通常是化学结构较为简单的化合物，通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色，是实现复杂药物分子合成的关键组成部分。

    特点
    1. 多样性：医药中间体种类繁多，根据所需药品的不同而不同。
    2. 复杂性：有些医药中间体本身可能较为简单，但通过一系列复杂的化学反应才能获得最终的药物成品。
    3. 安全性与纯度要求高：在制药行业中，医药中间体的安全性和纯度直接影响到最终产品的质量和效果。
    应用
    1. 合成新药：许多复杂结构的新药都是通过一些简单的中间体经过一系列复杂的化学反应而合成得到的。
    2. 药物改良：通过对现有药物中的某些关键中间体进行优化，可以开发出更有效的治疗手段或者降低副作用。
    3. 原料供应保障：确保医药中间体的稳定供应对于维持药品市场供给至关重要。
    生产与研发

    医药中间体的研发和生产是一个复杂的过程，通常包括以下几个步骤：

    • 合成设计：根据目标药物结构设计合适的合成路线。
    • 实验室规模合成与优化：通过小规模实验来验证并优化反应条件。
    • 中试放大：将实验室中的成功方案应用于工业化生产前的中间试验阶段。
    • 工业化生产：在确保安全性和质量的前提下进行大规模生产。
    发展趋势

    随着化学合成技术的进步和新技术的应用（如绿色化学、计算机辅助设计等），医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时，对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。

    下级分类

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— cis-1-Amino-4-tert-butylcyclohexane,cis-4-tert-Butyl-1-cyclohexanamine 2163-33-9 C10H21N
    cis-1-Amino-4-tert-butylcyclohexane,cis-4-tert-Butyl-1-cyclohexanamine
    —— sodium 2-mercaptopyridine N-oxide hydrate 304675-78-3 C5H4NOS*H2O*Na
    sodium 2-mercaptopyridine N-oxide hydrate
    —— (1R,4R)-Methyl 4-formylcyclohexanecarboxylate 54274-80-5 C9H14O3
    (1R,4R)-Methyl 4-formylcyclohexanecarboxylate
    —— Ethyl cis-4-hydroxycyclohexanecarboxylate 75877-66-6 C9H16O3
    Ethyl cis-4-hydroxycyclohexanecarboxylate
    —— p-tolyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranuronic acid methyl ester 61025-09-0 C20H24O9S
    p-tolyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranuronic acid methyl ester
    —— (S)-Qinoclidinole 18684-63-4 C8H14O
    (S)-Qinoclidinole
    —— (S)-5-benzyl-2-(2,6-dimethoxyphenyl)-6,6-diphenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate 1356582-08-5 BF4*C32H30N3O3
    (S)-5-benzyl-2-(2,6-dimethoxyphenyl)-6,6-diphenyl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate
    —— 2-methyl-5-ethoxymethyl-6-chloropyrimidine 749835-80-1 C8H11ClN2O
    2-methyl-5-ethoxymethyl-6-chloropyrimidine
    —— 6232-51-5 C18H11N3NaO8S
    —— 100-69-6 C7H6N*H
    —— 6300-24-9 C16H13N3NaO4S
    —— tert-butyl (3R,5S)-6-oxo-3,5-dihydroxy-3,5-O-isopropylidenehexanoate 123185-87-5 C13H22O5
    tert-butyl (3R,5S)-6-oxo-3,5-dihydroxy-3,5-O-isopropylidenehexanoate
    —— 6-aza-5,9-dioxo-9-(1,2-didehydrodibenzo[b,f]azocin-5(6H)-yl)nonanoic acid succinimidyl ester 1393350-27-0 C24H20N2O5
    6-aza-5,9-dioxo-9-(1,2-didehydrodibenzo[b,f]azocin-5(6H)-yl)nonanoic acid succinimidyl ester
    —— Ibrexafungerp Citrate 1965291-08-0 C50H75N5O11
    Ibrexafungerp Citrate
    —— 2-(4-aminophenylsulfonamido)-4-methylpyrimidine-5-carboxylic acid 95707-67-8 C12H12N4O4S
    2-(4-aminophenylsulfonamido)-4-methylpyrimidine-5-carboxylic acid
    —— Cedirogant 2055496-11-0 C24H20Cl3F3N2O3
    Cedirogant
    —— Pyrylium tetrafluoroborate 80279-50-1 C5H5BF4O
    Pyrylium tetrafluoroborate
    —— 3,4,6-tri-O-benzyl-2-O-acetyl-α-D-glucosyl trichloroimidate 108869-64-3 C31H32Cl3NO7
    3,4,6-tri-O-benzyl-2-O-acetyl-α-D-glucosyl trichloroimidate
    —— des-A,B-cholestane-8β,25-diol 66774-84-3 C18H34O2
    des-A,B-cholestane-8β,25-diol
    —— 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 5753-26-4 C7H17Cl3N2
    1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride
    —— 3-phenyl-1,4,2-dioxazol-5-one 19226-36-9 C8H5NO3
    3-phenyl-1,4,2-dioxazol-5-one
    —— 1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil 173379-67-4 C9H9FIN5O4
    1-(4-azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabino-furanosyl)uracil
    —— ethyl 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-seco-26,27-bisnorcholesta-5(E),7(E),10(19)-trien-25-oate 147125-14-2 C33H56O3Si
    ethyl 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-seco-26,27-bisnorcholesta-5(E),7(E),10(19)-trien-25-oate
    —— ((Z)-2-((3R,4R,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-4-(3-((tert-butyldimethylsilyl)oxy)propoxy)-2-methylenecyclohexylidene)ethyl)diphenylphosphine oxide 200636-54-0 C42H71O5PSi3
    ((Z)-2-((3R,4R,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-4-(3-((tert-butyldimethylsilyl)oxy)propoxy)-2-methylenecyclohexylidene)ethyl)diphenylphosphine oxide
    —— 17β-N,N-dimethylthiocarbamoyloxycarbonyl-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene 709002-84-6 C24H31F2NO5S
    17β-N,N-dimethylthiocarbamoyloxycarbonyl-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene
    —— [(1S,2S)-2-(trifluoromethyl)cyclopropyl]methanol 78376-92-8 C5H7F3O
    [(1S,2S)-2-(trifluoromethyl)cyclopropyl]methanol
    —— ethyl 5,5-dimethyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate 1346674-20-1 C12H17NO2
    ethyl 5,5-dimethyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate
    —— 6α,9α-difluoro-11β,21-dihydroxy-16α-methyl-17α-propionyloxypregna-1,4-diene-3,20-dione 22593-10-8 C25H32F2O6
    6α,9α-difluoro-11β,21-dihydroxy-16α-methyl-17α-propionyloxypregna-1,4-diene-3,20-dione
    —— paramethasone acetate 1597-82-6 C24H31FO6
    paramethasone acetate
    —— 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate 122111-11-9 C20H18F2O8S
    2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate
    —— 8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine 156632-03-0 C18H18ClN5O
    8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine
    —— 3-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-1-propene 214193-82-5 C17H25NO8
    3-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-1-propene
    —— 945491-51-0 C21H24ClIrN
    —— 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1,2-diphenyl-pentan-1-ol 17582-31-9 C27H33NO2
    1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1,2-diphenyl-pentan-1-ol
    —— 7-bromo-4-hydroxyquinolin-2(1H)-one 100748-65-0 C9H6BrNO2
    7-bromo-4-hydroxyquinolin-2(1H)-one
    —— methyl 4-fluoro-3-methoxy-5-nitrobenzoate 1951444-68-0 C9H8FNO5
    methyl 4-fluoro-3-methoxy-5-nitrobenzoate
    —— (4R,8S)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one 1179-87-9 C29H36O4
    (4R,8S)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
    —— (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene 112875-61-3 C39H68O3Si2
    (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
    —— ((1R,2S)-2-((2,4-dimethylpyrimidin-5-yloxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol 1369767-24-7 C17H19FN2O2
    ((1R,2S)-2-((2,4-dimethylpyrimidin-5-yloxy)methyl)-2-(3-fluorophenyl)cyclopropyl)methanol
    —— tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(L-valyl)amino]heptanoate 177423-00-6 C19H38N2O4
    tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(L-valyl)amino]heptanoate
    —— 4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane 886528-42-3 C14H18BF3O3
    4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane
    —— (1R,3s,5S)-8-Benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane 423165-13-3 C20H28N4
    (1R,3s,5S)-8-Benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
    —— (2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate 1599440-06-8 C20H20N2O5
    (2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate
    —— 3-(α-hydroxy)methylenebenzofuran-2(3H)-one 70450-82-7 C9H6O3
    3-(α-hydroxy)methylenebenzofuran-2(3H)-one
    —— TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE 177906-48-8 C11H22N2O2
    TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
    —— (2E)-3-(quinolin-8-yl)prop-2-enoic acid 754190-58-4 C12H9NO2
    (2E)-3-(quinolin-8-yl)prop-2-enoic acid
    —— exo-8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine 76272-36-1 C14H20N2
    exo-8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine
    —— 4-bromo-7-iodoindazole 1449008-23-4 C7H4BrIN2
    4-bromo-7-iodoindazole
    —— 3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione 1010100-26-1 C13H11BrN2O3
    3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
    —— 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)pyrimidine-5-carboxamide 1403859-14-2 C16H27N5O2
    2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)pyrimidine-5-carboxamide