医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质,它们通常是化学结构较为简单的化合物,通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色,是实现复杂药物分子合成的关键组成部分。
特点医药中间体的研发和生产是一个复杂的过程,通常包括以下几个步骤:
随着化学合成技术的进步和新技术的应用(如绿色化学、计算机辅助设计等),医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时,对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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(2S,5r)-1-boc-2,5-二甲基哌嗪 | tert-butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate | 548762-66-9 | C11H22N2O2 |
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(2S,5S)-5-羟基哌啶-2-甲酸盐酸盐 | (2S,5S)-5-hydroxypiperidine-2-carboxylic acid hydrochloride | 154307-84-3 | C6H11NO3*ClH |
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(2S,5S)-5-甲基吡咯烷-2-羧酸乙酯-2,2,2-三氟乙酸盐 | (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt | 676560-85-3 | C2HF3O2*C8H15NO2 |
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(2S,5S)-2,5-二甲基吡咯烷盐酸盐 | (2S,5S)-2,5-dimethylpyrrolidine hydrochloride | 138133-34-3 | C6H13N*ClH |
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(2S,5S)-(-)-2-叔丁基-3-甲基-5-苯基-4-咪唑啉酮 | (2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one | 346440-54-8 | C15H22N2O |
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(2S,5R)-7-氧代-6-(苯基甲氧基)-1,6-二氮杂双环[3.2.1]辛烷-2-羧酸乙酯 | (2S,5R)-ethyl 6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate | 1416134-63-8 | C16H20N2O4 |
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(2S,5R)-5-[(苯基甲氧基)氨基]-2-哌啶甲酰胺 | (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide | 1416134-49-0 | C13H19N3O2 |
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(2S,4s)-1-(叔丁氧基羰基)-4-氰基吡咯烷-2-羧酸 | (2S,4S)-1-(tert-butoxycarbonyl)-4-cyanopyrrolidine-2-carboxylic acid | 132622-71-0 | C11H16N2O4 |
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(2S,4S)-N-Boc-4-甲基吡咯烷-2-甲酸 | N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline | 364750-81-2 | C11H19NO4 |
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(2S,4S)-4-氟-2-(羟甲基)吡咯烷-1-羧酸叔丁酯 | tert-butyl (2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate | 317356-27-7 | C10H18FNO3 |
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(2S,4S)-2-氨基甲酰基-4-氟吡咯烷-1-羧酸叔丁酯 | tert-butyl (2S,4S)-2-carbamoyl-4-fluoropyrrolidine-1-carboxylate | 426844-22-6 | C10H17FN2O3 |
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(2S,4E)-5-氯-2-异丙基戊-4-烯酸甲酯 | methyl (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate | 387353-77-7 | C9H15ClO2 |
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(2S,3aR,7aS)-1H-八氢吲哚-2-羧酸 | (2S,3aR,7aS)-octahydroindolecarboxylic acid | 145438-94-4 | C9H15NO2 |
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(2S,3S)-2-氨基-3-甲氧基丁酸 | (2S,3S)-2-amino-3-methoxybutanoic acid | 104195-80-4 | C5H11NO3 |
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(2S,3S)-1,2-环氧-3-苄氧羰基氨基-4-苯基丁烷 | N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane | 128018-44-0 | C18H19NO3 |
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(2S,3R,4S,5S,6R)-2-(4-氯-3-(4-(((S)-3-四氢呋喃)氧代)苄基)苯基)-6-(羟甲基)四氢-2H-吡喃-2,3,4,5-四醇 | 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene | 1279691-35-8 | C23H27ClO8 |
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(2S,3R)-N-苄氧羰基-2,3-二苯基吗啉-6-酮 | (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one | 105228-46-4 | C24H21NO4 |
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(2S,3R)-3-氨基-2-羟基-4-苯丁酸 | (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid | 59554-14-2 | C10H13NO3 |
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(2S)-N-氯乙酰基-2-氰基四氢吡咯 | (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile | 207557-35-5 | C7H9ClN2O |
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(2S)-5-[(2,5-二氧代-1-吡咯烷基)氧基]-5-氧代-2-[(1-氧代十六烷基)氨基]戊酸叔丁酯 | Pal-Glu(OSu)-OtBu | 204521-63-1 | C29H50N2O7 |
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(2S)-4-氧代-2-(3-噻唑烷基羰基)-1-吡咯烷羧酸叔丁酯 | tert-butyl (2S)-4-oxo-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate | 401564-36-1 | C13H20N2O4S |
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(2S)-4,4-二氟吡咯烷-2-羧酸甲酯盐酸盐 | methyl (S)- 4,4-difluoropyrrolidine-2-carboxylate hydrochloride | 156046-05-8 | C6H9F2NO2*ClH |
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(2S)-2-苯基甲氧基戊烷-3-酮 | (S)-2-benzyloxy-3-pentanone | 132489-33-9 | C12H16O2 |
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(2S)-2-氨基-4-甲基-1-[(2R)-2-甲基环氧乙烷基]-1-戊酮 | (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one | 247068-84-4 | C9H17NO2 |
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(2S)-2-氨基-3-[4-(二(2-羟基乙基)氨基)苯基]丙酸 | 4-(bis-(2-hydroxyethyl)amino)-L-phenylalanine | 72143-20-5 | C13H20N2O4 |
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(2S)-2-(羟甲基)哌嗪-1,4-二羧酸4-苄基酯1-叔丁酯 | (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate | 385802-84-6 | C18H26N2O5 |
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(2S)-2-(8-氨基-1-溴咪唑并[1,5-a]吡嗪-3-基)-1-吡咯烷羧酸苯甲酯 | (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate | 1420478-88-1 | C18H18BrN5O2 |
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(2S)-2-(2-氧代吡咯烷-1-基)丁酸 | (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid | 102849-49-0 | C8H13NO3 |
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(2S)-2-(2,6-二氯苯基)-1-[(1R)-1-苯基乙基]-4-咪唑烷酮 | (2R)-(2,6-dichlorophenyl)-1-((1'R)-phenylethyl)-tetrahydro-1H-4-imidazolone | 1004754-99-7 | C17H16Cl2N2O |
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(2S)-1-[3-乙基-7-[[(1-氧代-3-吡啶基)甲基]氨基]吡唑并[1,5-A]嘧啶-5-基]-2-哌啶乙醇 | Dinaciclib | 779353-01-4 | C21H28N6O2 |
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(2S)-1-[(9H-芴-9-基甲氧基)羰基]-4-{[(2-甲基-2-丙基)氧基]羰基}-2-哌嗪羧酸 | (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid | 244132-27-2 | C25H28N2O6 |
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(2S)-(1-四氢嘧啶-2-酮)-3-甲基丁酸 | (S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid | 192725-50-1 | C9H16N2O3 |
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(2R,5S)-2,5-二甲基哌嗪-1-甲酸叔丁酯 | tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate | 309915-46-6 | C11H22N2O2 |
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(2R,4S)-乙基 5-([1,1'-联苯]-4-基)-4-((叔丁氧羰基)氨基)-2-甲基戊酸 | ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate | 149709-60-4 | C25H33NO4 |
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(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸 | (2R,4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid | 1012341-50-2 | C23H29NO4 |
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(2R,3r,4s,5r,6r)-3,4,5-三s(苄氧基)-2-溴-6-(3-苯基丙基)四氢-2H-吡喃 | 2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl bromide | 4196-35-4 | C34H35BrO5 |
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(2R,3S,4S,5S)-5-羟基-2,3,4-三(苄氧基)-5-[(苄氧基)甲基]-环己酮 | (1S)-(1(OH),2,4/1,3)-2,3,4-Tri-O-benzyl-1-C-<(benzyloxy)methyl>-5-oxo-1,2,3,4-cyclohexanetetrol | 115250-38-9 | C35H36O6 |
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(2R,3S)-N-苄氧羰基-2,3-二苯基吗啉-6-酮 | (5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one | 100516-54-9 | C24H21NO4 |
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(2R,3S)-2-[(1R)-1-[3,5-双(三氟甲基)苯基)乙氧基]-3-(4-氟苯基)吗啉 | cis(2R,3S)-2-({(1R)-1-[3,5bis(trifluoromethyl)phenyl]ethyl}oxy)-3-(4-fluorophenyl)morpholine | 171338-27-5 | C20H18F7NO2 |
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(2R,3S)-(-)-N-Boc-2,3-二苯基-6-氧代吗啉 | tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate | 112741-49-8 | C21H23NO4 |
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(2R,3R,4S,5S,6R)-2-[(2E)-3,7-二甲基辛-2,6-二烯氧基]-6-[[(2S,3R,4S,5R)-3,4,5-三羟基四氢吡喃-2-基]氧基甲基]四氢吡喃-3,4,5-三醇 | geranyl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside | 150995-11-2 | C21H36O10 |
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(2R,3R)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁烷-2,3-二醇 | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol | 133775-25-4 | C12H13F2N3O2 |
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(2R,3R)-2,3-双[(苄氧基)甲基]-环氧乙烷 | (2R,3R)-1,4-bis(benzyloxy)-2,3-epoxy butane | 80183-15-9 | C18H20O3 |
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(2R,3R)-2,3,4-三羟基丁酸钾 | potassium (2R,3R)-2,3,4-trihydroxybutanoate | 88759-55-1 | C4H7O5*K |
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(2R,3AR,11AS,12AR,14AR,Z)-2-(2-(4-异丙基噻唑-2-基)-7-甲氧基-8-甲基-4-喹啉氧基)-5-甲基-4,14-二氧-1,2,3,3A,4,5,6,7,8,9,11A,12,12A,13,14,14A-16氢环戊烷并[C]环丙基并[G][1,6]双氮杂十四烷-12A-羧酸乙酯 | 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-10(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-(2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid ethyl ester | 923604-57-3 | C37H46N4O6S |
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(2R, 3R)-3-(2, 5-二氟苯基)-3-羟基-2-甲基-4-[1H-(1, 2, 4)-三氮唑-1-基]硫代丁酰胺 | (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide | 368421-58-3 | C13H14F2N4OS |
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(2R)-4-苄基-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]吗啉-3-酮 | (2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one | 287930-75-0 | C21H19F6NO3 |
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(2R)-4-(2-(四氢吡喃-2-基)-羟基丙酰基)吗啉 | 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine | 135270-08-5 | C12H21NO4 |
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(2R)-2-氨基-3-[4-[双(2-氯乙基)氨基]苯基]丙酸 | melphalan | 13045-94-8 | C13H18Cl2N2O2 |
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(2R)-2-氨基-2-(2-吡啶基)乙醇 | (R)-2-(1-amino-2-hydroxyethyl)pyridine | 160821-26-1 | C7H10N2O |
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