间氨基苯乙酮是重要的医药及有机中间体,其下游产品具有重要用途。例如:
制备将2.0克间硝基苯乙酮、0.2克Pt/Bi2O3(Pt含量为0.2wt%)和10毫升无水甲醇加入50毫升间歇式反应釜中,先后用氮气和氢气置换反应釜内的气体3-5次。充入氢气至压力1.0MPa,然后在600-800转/分钟的搅拌速度下升温至70℃。如果总压力下降至0.5MPa以下,则补充氢气至初始压力。4小时后总压力不再变化,停止搅拌并冷却至室温。
对反应后的混合物进行离心分离:底部为黄色催化剂,上清液呈绿色(若间硝基苯乙酮转化不完全,则上清液为黄绿色),副产物可能包括亚硝基化合物。取少量上清液采用气相色谱分析,发现间硝基苯乙酮的转化率大于99.9%,间氨基苯乙酮的选择性也大于99.9%。
通过旋转蒸发去除滤液中的甲醇后得到间氨基苯乙酮,分离收率高达99%。
化学性质从乙醇中结晶出苍黄色片状体,熔点为98-99℃,沸点289-290℃。易溶于醇类但不溶于水,在水蒸气中的部分挥发性也较高。
用途间氨基苯乙酮主要用于合成肾上腺素药物、催眠药扎来普隆等,还可作为有机合成原料。
生产方法 类别有毒物品
毒性分级中毒
急性毒性口服-大鼠LD50: 1870毫克/公斤
刺激数据皮肤-兔子500 毫克/24小时 轻度
可燃性危险特性可燃;燃烧产生有毒氮氧化物烟雾
储运特性库房通风、低温干燥
灭火剂中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
1-(3-叠氮苯基)乙酮 | 3-azidoacetophenone | 70334-60-0 | C8H7N3O | 161.163 |
—— | 3,3'-Diacetyl-azobenzol | 94066-64-5 | C16H14N2O2 | 266.299 |
3-乙基苯胺 | m-ethylaniline | 587-02-0 | C8H11N | 121.182 |
间硝基苯乙酮 | 3-Nitroacetophenone | 121-89-1 | C8H7NO3 | 165.148 |
3-异丙基苯胺 | 3-Isopropylaniline | 5369-16-4 | C9H13N | 135.209 |
苯乙酮 | acetophenone | 98-86-2 | C8H8O | 120.151 |
3-(1-羟乙基)苯胺 | 3-(1-hydroxyethyl)aniline | 2454-37-7 | C8H11NO | 137.181 |
间氨基苯甲酸 | meta-aminobenzoic acid | 99-05-8 | C7H7NO2 | 137.138 |
3-氨基苯甲酰胺 | 3-Aminobenzamide | 3544-24-9 | C7H8N2O | 136.153 |
—— | 3-(prop-1-en-2-yl)aniline | 23809-98-5 | C9H11N | 133.193 |
中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
1-(3-氨基苯基)-2-溴乙酮 | 1-(3-aminophenyl)-2-bromoethanone | 57946-55-1 | C8H8BrNO | 214.062 |
1-(3-(甲基氨基)苯基)乙酮 | 3'-(N-methylamino)acetophenone | 42865-75-8 | C9H11NO | 149.192 |
乙酮,1-[3-(羟氨基)苯基]- | 1-(3-(hydroxyamino)phenyl)ethanone | 10517-46-1 | C8H9NO2 | 151.165 |
1-(3-肼基苯基)乙酮 | 3-acetylphenylhydrazine | 79266-25-4 | C8H10N2O | 150.18 |
1-(3-亚硝基苯基)乙酮 | 1-(3-nitrosophenyl)ethan-1-one | 105333-30-0 | C8H7NO2 | 149.149 |
—— | 3'-ethylaminoacetophenone | 134812-13-8 | C10H13NO | 163.219 |
N-(3-乙酰基苯基)甲酰胺 | N-(3-acetylphenyl)formamide | 72801-78-6 | C9H9NO2 | 163.176 |
二甲氨基苯乙酮 | 1-(3-dimethylaminophenyl)-1-ethanone | 18992-80-8 | C10H13NO | 163.219 |
异氰酸3-乙酰基苯酯 | 3-acetylphenyl isocyanate | 23138-64-9 | C9H7NO2 | 161.16 |
3-乙酰基异硫氰酸苯酯 | 3-Acetyl-phenylisothiocyanat | 3125-71-1 | C9H7NOS | 177.227 |
1-(3-叠氮苯基)乙酮 | 3-azidoacetophenone | 70334-60-0 | C8H7N3O | 161.163 |
1-(3-苯基氨基苯基)-乙酮 | 1-(3-(phenylamino)phenyl)ethanone | 23699-65-2 | C14H13NO | 211.263 |
1-(3-氨基-4-溴苯基)乙酮 5-乙酰基-2-溴苯胺 | 3'-amino-4'-bromoacetophenone | 37148-51-9 | C8H8BrNO | 214.062 |
—— | 1-[3-(isopropylamino)phenyl]-ethanone | —— | C11H15NO | 177.246 |
—— | 3,3'-diaminodihydrochalcone | 134271-80-0 | C15H16N2O | 240.305 |
—— | m-Propylamino-acetophenon | 56915-88-9 | C11H15NO | 177.246 |
—— | 1-(3-allylamino-phenyl)-ethanone | 371754-87-9 | C11H13NO | 175.23 |
2-(3-乙酰基苯基)胍 | 3-Guanidinoacetophenon | 24723-13-5 | C9H11N3O | 177.206 |
—— | 1-(3-Phenyldiazenylphenyl)ethanone | 4865-93-4 | C14H12N2O | 224.262 |
—— | 3,3'-Diacetyl-azobenzol | 94066-64-5 | C16H14N2O2 | 266.299 |
1-(2,3-二氨基苯基)乙酮 | monoacetylphenylenediamine | 159724-49-9 | C8H10N2O | 150.18 |
—— | m-(tert-Butylamino)acetophenone | 73679-98-8 | C12H17NO | 191.273 |
3-乙基苯胺 | m-ethylaniline | 587-02-0 | C8H11N | 121.182 |
—— | 3-(3-Acetyl-phenylamino)-propionitrile | 830319-80-7 | C11H12N2O | 188.229 |
1-[3-(3-羟基丙基氨基)-苯基]-乙酮 | 1-[3-(3-hydroxypropylamino)-phenyl]-ethanone | 1019209-63-2 | C11H15NO2 | 193.246 |
3-乙酰胺基苯乙酮 | 3-Acetamidoacetophenone | 7463-31-2 | C10H11NO2 | 177.203 |
1-[3-(4-羟基丁基氨基)-苯基]-乙酮 | 1-[3-(4-hydroxybutylamino)-phenyl]-ethanone | 1019209-64-3 | C12H17NO2 | 207.272 |
—— | 1-(3-acetylphenyl)urea | 42865-71-4 | C9H10N2O2 | 178.191 |
1-(3-乙酰苯基)-2-硫脲 | 1-(3-acetylphenyl)thiourea | 86801-04-9 | C9H10N2OS | 194.257 |
1-(5-氨基-2-氟苯基)-1-乙酮 | 1-(5-amino-2-fluorophenyl)ethanone | 67500-19-0 | C8H8FNO | 153.156 |
—— | 1-(3-acetylphenyl)-3,3-dimethyltriazene | 52416-17-8 | C10H13N3O | 191.233 |
—— | N-(3-acetylphenyl)glycine | 91950-08-2 | C10H11NO3 | 193.202 |
1-(5-氨基-2-溴苯基)乙酮 | 1-(5-amino-2-bromophenyl)ethanone | 149914-98-7 | C8H8BrNO | 214.062 |
—— | 3'-aminochalcone | —— | C15H13NO | 223.274 |
—— | (E)-1-(3′-aminophenyl)-3-phenylprop-2-en-1-one | 108714-19-8 | C15H13NO | 223.274 |
间硝基苯乙酮 | 3-Nitroacetophenone | 121-89-1 | C8H7NO3 | 165.148 |
1-(3-(苄基氨基)苯基)乙酮 | 1-(3-(benzylamino)phenyl)ethanone | 1063752-59-9 | C15H15NO | 225.29 |
—— | 1-[3-(Benzylideneamino)phenyl]ethanone | 387370-64-1 | C15H13NO | 223.274 |
—— | (E)-1-(3′-aminophenyl)-3-(4-methylphenyl)prop-2-en-1-one | 25870-78-4 | C16H15NO | 237.301 |
—— | 4-Methyl-3'-aminochalcon | 25870-78-4 | C16H15NO | 237.301 |
N-(3-乙酰基苯基)丙酰胺 | N-(3-acetylphenyl)propionamide | 39569-28-3 | C11H13NO2 | 191.23 |
N-(3-乙酰基-苯基)-2-氯乙酰胺 | N-(3-acetylphenyl)-2-chloroacetamide | 42865-69-0 | C10H10ClNO2 | 211.648 |
N-(3-乙酰基苯基)-2-丙酰胺 | N-(3-acetylphenyl)-2-propenamide | 104373-97-9 | C11H11NO2 | 189.214 |
1-(3-乙酰基苯基)-3-苯基脲 | 3'-N-(N'-phenylurenyl)acetophenone | 42865-77-0 | C15H14N2O2 | 254.288 |
—— | N-(3-acetyl-phenyl)-N'-methyl-thiourea | 81467-06-3 | C10H12N2OS | 208.284 |
3-乙酰氨基-2-溴苯乙酮 | 3'-Bromacetylacetanilid | 30095-56-8 | C10H10BrNO2 | 256.099 |
—— | methyl (3-acetylphenyl)carbamate | 87743-55-3 | C10H11NO3 | 193.202 |
1-(3-氨基-2-溴苯基)乙酮 | 1-(3-amino-2-bromophenyl)ethanone | 1166988-10-8 | C8H8BrNO | 214.062 |
—— | N-(3-acetylphenyl)propanimidoyl chloride | 1611477-30-5 | C11H12ClNO | 209.675 |
—— | m-acetyl-isobutyranilide | 80945-16-0 | C12H15NO2 | 205.257 |
—— | 3-[(3-acetylphenyl)amino]benzoic acid | 1359967-51-3 | C15H13NO3 | 255.273 |
—— | [N,N-bis(2-chloroxyethyl)-3-amino]acetophenone | 40673-74-3 | C12H15Cl2NO | 260.163 |
—— | N-(3-acetylphenyl)-3-chloropropanamide | —— | C11H12ClNO2 | 225.675 |
—— | 3- |
40673-66-3 | C12H17NO3 | 223.272 |
—— | 3-acetyl-N,N-diallylaniline | 1236376-42-3 | C14H17NO | 215.295 |
3-(3-乙酰基苯基)-1,1-二甲基脲 | N'-(3-acetylphenyl)-N,N-dimethyl-urea | 42865-65-6 | C11H14N2O2 | 206.244 |
N-(3-乙酰基苯基)甲烷磺酰胺 | 1-[3-[N-(methylsulfonyl)amino]phenyl]ethanone | 2417-42-7 | C9H11NO3S | 213.257 |
—— | 1-phenyl-2-(3-acetylphenylamino)ethanone | —— | C16H15NO2 | 253.301 |
—— | m-Dichloroacetamidoacetophenon | 20501-84-2 | C10H9Cl2NO2 | 246.093 |
—— | 3-(3-acetylanilino)-1-phenylpropan-1-one | 951312-73-5 | C17H17NO2 | 267.327 |
—— | 1-(3-Acetylphenyl)-3-ethylthiourea | 194784-43-5 | C11H14N2OS | 222.311 |
—— | 1-[3-[(4-Chlorophenyl)methylamino]phenyl]ethanone | 1063752-61-3 | C15H14ClNO | 259.735 |
—— | N-(3-acetylphenyl)pentanamide | —— | C13H17NO2 | 219.283 |
—— | 1-(3-acetylphenyl)piperazine | 155088-96-3 | C12H16N2O | 204.272 |
—— | ethyl N-(m-acetylphenyl)carbamate | 39569-24-9 | C11H13NO3 | 207.229 |
—— | 1-[3-[(4-Fluorophenyl)methylideneamino]phenyl]ethanone | 349456-27-5 | C15H12FNO | 241.265 |
N-(3-乙酰基苯基)-2,2,2-三氟乙酰胺 | N-(3-acetylphenyl)-2,2,2-trifluoroacetamide | 56915-87-8 | C10H8F3NO2 | 231.174 |
3-(1-羟乙基)苯胺 | 3-(1-hydroxyethyl)aniline | 2454-37-7 | C8H11NO | 137.181 |
(S)-1-(3-氨基苯基)乙-1-醇 | 3-aminoacetophenone | 201939-72-2 | C8H11NO | 137.181 |
N-(3-乙酰基苯基)-n-甲基乙酰胺 | N-(3-acetylphenyl)-N-methylacetamide | 325715-13-7 | C11H13NO2 | 191.23 |
—— | N-(3-acetyl-phenyl)-2-dimethylamino-acetamide | 628305-95-3 | C12H16N2O2 | 220.271 |
—— | N-(3-acetylphenyl)hexanamide | —— | C14H19NO2 | 233.31 |
—— | 1-[3-[(4-Hydroxyphenyl)methylideneamino]phenyl]ethanone | 387370-65-2 | C15H13NO2 | 239.274 |
—— | Pentanethioic acid (3-acetyl-phenyl)-amide | —— | C13H17NOS | 235.35 |
—— | 1-(3-Acetylphenyl)-3-propan-2-ylthiourea | 502582-13-0 | C12H16N2OS | 236.338 |
—— | N,N'-bis(3-acetylphenyl)pentanediamide | —— | C21H22N2O4 | 366.417 |
—— | N-(3-acetylphenyl)heptanamide | —— | C15H21NO2 | 247.337 |
—— | 2-(3-Acetylanilino)-1-(4-methylphenyl)ethanone | —— | C17H17NO2 | 267.327 |
—— | 1-(3-Acetylphenyl)-3-(2-chloroethyl)urea | 379697-30-0 | C11H13ClN2O2 | 240.689 |
—— | N-(3-acetylphenyl)nonanamide | —— | C17H25NO2 | 275.391 |
—— | 1-(3-Acetylphenyl)-3-propylthiourea | 894149-50-9 | C12H16N2OS | 236.338 |
—— | N-(3-acetyl-phenyl)-N'-allyl-thiourea | 104509-97-9 | C12H14N2OS | 234.322 |
—— | (E)-1-(3-aminophenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one | 6110-63-0 | C17H18N2O | 266.343 |
1-(3-氨基-4-硝基苯基)乙酮 | 3-amino-4-nitroacetophenone | 79127-41-6 | C8H8N2O3 | 180.163 |
—— | N-(3-acetylphenyl)-2-bromopropionamide | 1017663-87-4 | C11H12BrNO2 | 270.126 |
—— | N-(3-acetylphenyl)methacrylamide | —— | C12H13NO2 | 203.241 |
—— | 3-(prop-1-en-2-yl)aniline | 23809-98-5 | C9H11N | 133.193 |
—— | 1-(3-ethanoylphenyl)-3-(4-chlorophenyl)urea | —— | C15H13ClN2O2 | 288.733 |
—— | (E)‐1‐(3‐((4‐(dimethylamino)benzylidene)amino)phenyl)ethan‐1‐one | —— | C17H18N2O | 266.343 |
—— | 1-(3-Acetylphenyl)-3-butylthiourea | 380333-60-8 | C13H18N2OS | 250.365 |
—— | 2-bromo-1-[3-[(methylsulfonyl)amino]phenyl]ethanone | 2065-04-5 | C9H10BrNO3S | 292.153 |
3-乙酰基苯基氨基甲酸叔丁酯 | tert-butyl (3-acetylphenyl)carbamate | 79537-70-5 | C13H17NO3 | 235.283 |