原料药中间体
原料药中间体是指在药物合成过程中用于生成最终活性成分（即原料药）的化学物质。这些中间体在制药工业中扮演着重要角色，它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能，可以将原料药中间体分为以下几个类别：
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起始物料：这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。
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关键中间体：这些中间体在整个合成过程中起着核心作用，通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。
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保护基团：在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”，防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。
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催化剂和添加剂：虽然不直接形成最终产品，但这些物质能够促进化学反应、提高产率或改善产品的质量特性。
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分离纯化溶剂：这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。
选择合适的原料药中间体对于保证药物的安全性和有效性至关重要，因此，在其开发过程中需要考虑多个因素，包括成本效益、反应条件的可控性以及环境友好型等方面。
下级分类
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| (-)-3-(三氟乙酰基)樟脑 | (+)-3-(trifluoroacetyl)camphor | 207742-84-5 | C12H15F3O2 |
|
| (-)-(S)-3-氧代环戊烷羧酸 | (-)-(S)-3-oxocyclopentanecarboxylic acid | 71830-06-3 | C6H8O3 |
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| (-)-(3Ar,6ar)-3a,6a-二氢-2,2-二甲基-4H-环戊并-1,3-二氧代-4-酮 | (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one | 115509-13-2 | C8H10O3 |
|
| (+/-)-1-苄氧羰基-4-Boc-哌嗪-2-羧酸甲酯 | 1-benzyl 4-(tert-butyl) 2-methyl piperazine-1,2,4-tricarboxylate | 126937-42-6 | C19H26N2O6 |
|
| (+/-)-1-(1,3-苯并二氧戊环-5-基)-2-溴-1-戊酮 | 1-(benzo[d]-1,3-dioxol-5-yl)-2-bromopentan-1-one | 146721-06-4 | C12H13BrO3 |
|
| (+)-3-溴樟脑 | (1R)-3-endo-bromocamphor | 10293-06-8 | C10H15BrO |
|
| (+)-(1S,2R)-米那普仑 | (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide | 96847-54-0 | C15H22N2O |
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| ()-N-(四氢-2,5-二氧代-3-呋喃基)乙酰胺 | <i>N</i>-acetyl-<i>DL</i>-aspartic acid-anhydride | 3397-54-4 | C6H7NO4 |
|
| ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯盐酸盐 | 4-nitrophenyl (5-thiazolyl)methyl carbonate hydrochloride | 154212-59-6 | C11H8N2O5S*ClH |
|
| ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯 | 4-nitrophenyl (thiazol-5-ylmethyl) carbonate | 144163-97-3 | C11H8N2O5S |
|
| ((4-羟基丁基)氮杂二基)双(己烷-6,1-二基)双(2-己基癸酸酯) | ALC-0315 | 2036272-55-4 | C48H95NO5 |
|
| ((3aR,4S,6aS)-5-乙酰氧基-2-氧代六氢-2H-环戊并[b]呋喃-4-基)甲基 乙酸酯 | ((3aR,4S,5R,6aS)-5-acetoxy-2-oxohexahydro-2H-cyclopenta[b]furan-4-yl)methyl acetate | 62939-82-6 | C12H16O6 |
|
| ((3R,4S)-3-氟哌啶-4-基)氨基甲酸叔丁酯 | tert-butyl N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamate | 1630815-57-4 | C10H19FN2O2 |
|
| ((3AR,4R,6R,6AR)-6-(4-(羟氨)-2-恶嘧啶-1(2H)-甲基)-2,2-二甲基四氢呋喃[3,4-D][1,3]二氧醇-4-基)异丁酸甲酯 | molnupiravir acetonide | 2346620-55-9 | C16H23N3O7 |
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| ((2S)-2-氨基丙基)氨基甲酸叔丁酯 | tert-butyl (S)-(2-aminopropyl)carbamate | 121103-15-9 | C8H18N2O2 |
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| ((2R,3r,4r)-3-((4-氯苯甲酰基)氧基)-4-氟-4-甲基-5-氧代四氢呋喃-2-基)甲基4-氯苯甲酸 | ((2R,3R,4R) 3-(4-chlorobenzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl-4-chlorobenzoate | 1294481-79-0 | C20H15Cl2FO6 |
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| ((2R,3R,4R)-3-(苯甲酰氧基)-4-氟-4-甲基-5-氧代四氢呋喃-2-基)苯甲酸甲酯 | ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate | 874638-80-9 | C20H17FO6 |
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| ((1R,3R,4R)-3-羟基-4-甲基环己基)氨基甲酸叔丁酯 | tert-butyl ((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)carbamate | 1403864-94-7 | C12H23NO3 |
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| ((1R,2S)-2-氨基环己基)氨基甲酸叔丁酯 | tert-butyl ((1R,2S)-2-aminocyclohexyl)carbamate | 364385-54-6 | C11H22N2O2 |
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| ((1R,2R)-2-羟基-1-羟甲基-2-苯基乙基)氨基甲酸叔丁酯 | ((1R,2R)-2-hydroxy-1-hydroxymethyl-2-phenylethyl)carbamic acid tert-butyl ester | 1009093-14-4 | C14H21NO4 |
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| —— | (3-bromophenyl)dimethylphosphine oxide | 60398-84-7 | C8H10BrOP |
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| —— | 1-((trans)-4-methylcyclohexyl)ethanone | 18446-90-7 | C9H16O |
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| —— | 4-chloro-N-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide | 1923844-48-7 | C24H24ClFN2O |
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| —— | N-(4-((6-azidohexyloxy)diphenylsilyloxy)butyl)-1-(5-((3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide | 1260247-50-4 | C43H67N7O9SSi |
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| —— | bis(4-bromophenyl)phosphine oxide | 15754-53-7 | C12H9Br2OP |
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| —— | 5-(2-chloroacetamido)-2,4,6-triiodo-N,N'-bis(2,3-bis(2-chloroacetoxy)propyl)isophthalamide | 155887-14-2 | C24H23Cl5I3N3O11 |
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| —— | Pubchem_57369830 | 70431-34-4 | C11H21NNa3O7+3 |
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| —— | sulfopin | 2451481-08-4 | C11H20ClNO3S |
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| —— | 17-Alpha-cyano-9-alpha,17-beta-dihydroxyandrost-4-en-3-one | 116256-35-0 | C20H27NO3 |
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| —— | Gpl23NZ2Q9 | 2061897-68-3 | C34H38N4O5 |
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| —— | TERT-BUTYL TRANS-4-AMINOCYCLOHEXYLMETHYLCARBAMATE | 192323-07-2 | C12H24N2O2 |
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| —— | trans-4-((tert-butyldimethylsilyl)oxy)cyclohexane-1-carboxylic acid | 955401-29-3 | C13H26O3Si |
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| —— | (1<i>RS</i>:2<i>SR</i>:3<i>RS</i>)-pinanediol-(2.3) | 18680-27-8 | C10H18O2 |
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| —— | 2-cyano-5-iodopyrimidine | 1083329-46-7 | C5H2IN3 |
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| —— | 9,9-dipropylfluorene-2,7-dicarboxylic acid | 204265-35-0 | C21H22O4 |
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| —— | 3,4-Methylenedioxy-N-benzylcathinone (hydrochloride) | 1823274-68-5 | C17H18ClNO3 |
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| —— | Bicyclo[2.2.1]heptan-2-one,7,7-trimethyl-, (1R)- | 10293-06-8 | C10H15BrO |
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| —— | Neptinib | 2085843-51-0 | C22H23ClFN5O2 |
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| —— | (S)-2-bromo-1-(4-chlorophenyl)ethanol | 179065-35-1 | C8H8BrClO |
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| —— | 2-(3-bromo-4-methylphenyl)propan-2-ol | 1345961-02-5 | C16H25BO3 |
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| —— | DOTA-cyclo-RGDfK | 909024-55-1 | C43H67N13O14 |
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| —— | Sodium;5-amino-8-phenyldiazenylnaphthalene-2-sulfonic acid | 6300-23-8 | C16H13N3NaO3S+ |
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| —— | N-(o-Benzyloxy-benzoyl)-glycin-aethylester | 68939-33-3 | C17H17NO4 |
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| —— | filgotinib maleate | 1802998-75-9 | C4H4O4*C21H23N5O3S |
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| —— | 3-Cyclopropylcyclohexan-1-amine hydrochloride | 1354952-79-6 | C9H18ClN |
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| —— | (R)-4-benzyl-3-((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-carbonyl)oxazolidin-2-one | 165115-89-9 | C22H20F2INO4 |
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| —— | 5-Chloro-3-sulfamoylthiophene-2-carboxylic acid | 1017791-22-8 | C5H4ClNO4S2 |
|
| —— | Halobetasol Dipropionate | 886204-51-9 | C28H35ClF2O6 |
|
| —— | 5-ethylamino-4-methyl-1,2-benzoquinone-2-oxime | 174909-38-7 | C9H12N2O2 |
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| —— | 1-[4-(pyridin-2-yl)phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane trihydrochloride | 198904-87-9 | C22H26N4O*3ClH |
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