(3-bromophenyl)dimethylphosphine oxide | 60398-84-7

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-bromophenyl)dimethylphosphine oxide
• 英文别名: 1-bromo-3-dimethylphosphorylbenzene
• CAS: 60398-84-7
• 化学式: C₈H₁₀BrOP
• 分子量: 233.045
• InChiKey: VAVCDNNDYJHWQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  357.0±34.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-bromophenyl)dimethylphosphine oxide 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium phosphate 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 3.5h， 生成 (3-(3-(difluoro(imidazo[1,2-a]pyridin-6-yl)methyl)[1,2,4]triazolo [4,3-b]pyridazin-6-yl)phenyl)dimethylphosphine oxide
  参考文献：
  名称：

  WO2020124060A5

  摘要：

  公开号：

  WO2020124060A5
• 作为产物：
  描述：

  1,3-二溴苯 、 二甲基氧化膦 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 三乙胺 作用下， 以 乙腈 为溶剂， 以60.285 %的产率得到(3-bromophenyl)dimethylphosphine oxide
  参考文献：
  名称：

  [EN] TYK2 SELECTIVE INHIBITOR AND USE THEREOF
  [FR] INHIBITEUR SÉLECTIF DE TYK2 ET SON UTILISATION
  [ZH] TYK2选择性抑制剂及其用途

  摘要：

  一种式(I)化合物，或其互变异构体、内消旋体、外消旋体、对映异构体、非对映异构体或其可药用的盐，以及其用于制备用于治疗TYK2介导的疾病的药物的用途。

  公开号：

  WO2022242697A1

文献信息

• [EN] USE OF PHOSPHINE OXIDE COMPOUNDS IN A SEMICONDUCTING LAYER COMPRISED IN AN ELECTRONIC DEVICE<br/>[FR] UTILISATION DE COMPOSÉS D'OXYDE DE PHOSPHINE DANS UNE COUCHE SEMI-CONDUCTRICE INCORPORÉE DANS UN DISPOSITIF ÉLECTRONIQUE
  申请人：NOVALED GMBH

  公开号：WO2018215442A1

  公开（公告）日：2018-11-29

  The present invention relates to the use of a compound represented by the general formula (I) wherein A1 and A2 are independently selected from C1 to C60 carbon-containing groups; A3 to A9 are independently selected from hydrogen, C1 to C60 carbon-containing groups, or halogen; R1 and R2 are independently selected from C1 to C60 carbon-containing groups which are attached to the phosphorous atom by a sp3-hybridized carbon atom; X is a single covalent bond or a spacer group consisting of 1 to 120 covalently bound atoms; in a semiconducting layer comprised in an electronic device, a respective semiconducting layer, a respective electronic device and respective compounds.

  本发明涉及一种化合物的使用，该化合物由通式（I）表示，其中A1和A2分别选自C1至C60碳含基团；A3至A9分别选自氢、C1至C60碳含基团或卤素；R1和R2分别选自通过sp3杂化碳原子连接到磷原子的C1至C60碳含基团；X是单共价键或由1至120个共价结合的原子组成的间隔基团；在电子器件中包含的半导体层中，各自的半导体层、各自的电子器件和各自的化合物。
• ORGANIC SEMICONDUCTIVE LAYER COMPRISING PHOSPHINE OXIDE COMPOUNDS
  申请人：Novaled GmbH

  公开号：EP3171418A1

  公开（公告）日：2017-05-24

  The present invention relates to an organic semiconductive layer which is an electron transport layer and/or an electron injection layer and/or an n-type charge generation layer, the organic semiconductive layer comprising at least one compound of formula (1) wherein R1 and R2 are each independently selected from C1 to C16 alkyl; Ar1 is selected from C6 to C14 arylene or C3 to C12 heteroarylene; Ar2 is independently selected from C14 to C40 arylene or C8 to C40 heteroarylene; R3 is independently selected from H, C1 to C12 alkyl or C10 to C20 aryl; wherein each of Ar1, Ar2 and R3 may each independently be unsubstituted or substituted with at least one C1 to C12 alky group; n is 0 or 1; and m is 1 in case of n = 0; and m is 1 or 2 in case of n = 1, phosphine oxide compounds comprised therein and to organic electroluminescent devices comprising such layers and compounds.

  本发明涉及一种作为电子传输层和/或电子注入层和/或 n 型电荷发生层的有机半导体层，该有机半导体层包括至少一种式（1）化合物 其中 R1 和 R2 各自独立地选自 C1 至 C16 烷基；Ar1 选自 C6 至 C14 芳基或 C3 至 C12 杂芳基；Ar2 独立地选自 C14 至 C40 芳基或 C8 至 C40 杂芳基；R3 独立地选自 H、C1 至 C12 烷基或 C10 至 C20 芳基；其中 Ar1、Ar2 和 R3 可各自独立地未被取代或被至少一个 C1 至 C12 烷基取代；n 为 0 或 1；在 n = 0 的情况下，m 为 1；在 n = 1 的情况下，m 为 1 或 2。
• USE OF PHOSPHINE OXIDE COMPOUNDS IN A SEMICONDUCTING LAYER COMPRISED IN AN ELECTRONIC DEVICE
  申请人：Novaled GmbH

  公开号：EP3406617A1

  公开（公告）日：2018-11-28

  The present invention relates to the use of a compound represented by the general formula (I) wherein A1 and A2 are independently selected from C1 to C60 carbon-containing groups; A3 to A9 are independently selected from hydrogen, C1 to C60 carbon-containing groups, or halogen; R1 and R2 are independently selected from C1 to C60 carbon-containing groups which are attached to the phosphorous atom by a sp3-hybridized carbon atom; X is a single covalent bond or a spacer group consisting of 1 to 120 covalently bound atoms; in a semiconducting layer comprised in an electronic device, a respective semiconducting layer, a respective electronic device and respective compounds.

  本发明涉及通式 (I) 所代表的化合物的用途 其中，A1 和 A2 独立地选自 C1 至 C60 含碳基团；A3 至 A9 独立地选自氢、C1 至 C60 含碳基团或卤素；R1 和 R2 独立地选自 C1 至 C60 含碳基团，这些基团通过 sp3 杂化碳原子连接到磷原子上；X 是单个共价键或由 1 至 120 个共价结合原子组成的间隔基团；在电子设备、各自的半导体层、各自的电子设备和各自的化合物中所包含的半导体层中使用。
• ORGANIC MATERIAL FOR AN ELECTRONIC OPTOELECTRONIC DEVICE AND ELECTRONIC DEVICE COMPRISING THE ORGANIC MATERIAL
  申请人：Novaled GmbH

  公开号：EP3524593A1

  公开（公告）日：2019-08-14

  The present invention relates to an organic material and to an electronic device comprising the organic material, particularly to an electroluminescent device, particularly to an organic light emitting diode (OLED), wherein the semiconducting material comprises a multiple-substituted phenyl moiety, an aryl moiety with at least two fused rings, a polar moiety and optional linkers between these moieties.

  本发明涉及一种有机材料和一种包含该有机材料的电子装置，特别是一种电致发光装置，尤其是一种有机发光二极管（OLED），其中半导体材料包含一个多取代苯基、一个至少有两个融合环的芳基、一个极性分子和这些分子之间可选的连接体。
• ORGANIC COMPOUNDS, ORGANIC SEMICONDUCTOR LAYER AND ORGANIC ELECTRONIC DEVICE
  申请人：Novaled GmbH

  公开号：EP3643720A1

  公开（公告）日：2020-04-29

  The present invention relates to a compound according to formula 1: suitable for use as a layer material for electronic devices, and to an organic semiconductor layer comprising at least one compound according to formula 1, as well as to an organic electronic device comprising at least one organic semiconductor layer, and a method of manufacturing the same.

  本发明涉及一种符合式 1 的化合物： 本发明涉及一种适合用作电子设备层材料的根据式 1 的化合物，涉及一种包含至少一种根据式 1 的化合物的有机半导体层，还涉及一种包含至少一种有机半导体层的有机电子设备，以及制造这种设备的方法。