原料药中间体是指在药物合成过程中用于生成最终活性成分(即原料药)的化学物质。这些中间体在制药工业中扮演着重要角色,它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能,可以将原料药中间体分为以下几个类别:
起始物料:这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。
关键中间体:这些中间体在整个合成过程中起着核心作用,通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。
保护基团:在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”,防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。
催化剂和添加剂:虽然不直接形成最终产品,但这些物质能够促进化学反应、提高产率或改善产品的质量特性。
分离纯化溶剂:这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。
选择合适的原料药中间体对于保证药物的安全性和有效性至关重要,因此,在其开发过程中需要考虑多个因素,包括成本效益、反应条件的可控性以及环境友好型等方面。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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1-([1,2,4]噻唑并[1,5-a]-6-吡啶基)-2-(6-甲基-2-吡啶基)乙烷-1,2-二酮 | 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione | 356560-84-4 | C14H10N4O2 |
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1-(N-Boc-氨乙基)哌嗪 | tert-butyl (2-(piperazin-1-yl)ethyl)carbamate | 140447-78-5 | C11H23N3O2 |
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1-(Boc-氨基)环丙基甲醇 | tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate | 107017-73-2 | C9H17NO3 |
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1-(6-硝基吡啶-3-基)哌嗪 | 1-(6-nitropyridin-3-yl)piperazine | 775288-71-6 | C9H12N4O2 |
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1-(5-溴吡啶-2-基)哌啶-4-羧酸乙酯 | ethyl 1-(5-bromopyridin-2-yl)piperidine-4-carboxylate | 364794-70-7 | C13H17BrN2O2 |
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1-(4-甲氧苯基)-2-苄胺基丙烷 | N-benzyl-1-(4-methoxyphenyl)propan-2-amine | 43229-65-8 | C17H21NO |
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1-(4-甲氧基苯基)哌嗪盐酸盐 | 4-(p-methoxyphenyl)piperazine dihydrochloride | 38869-47-5 | C11H16N2O*2ClH |
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1-(4-溴苯基)环丁胺盐酸盐 | 1-(4-bromophenyl)cyclobutanamine hydrochloride | 1193389-40-0 | C10H12BrN*ClH |
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1-(4-溴苯基)-4,4,4-三氟-1,3-丁二酮 | 4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione | 18931-61-8 | C10H6BrF3O2 |
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1-(4-氯苯基)吡咯 | 1-(4-chlorophenyl)-1H-pyrrole | 5044-38-2 | C10H8ClN |
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1-(4-氯苄基)哌嗪 | 1-[(4-chlorophenyl)methyl]piperazine | 23145-88-2 | C11H15ClN2 |
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1-(4-氨基苯基)-4-(4-羟基苯基)哌嗪 | 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine | 74853-08-0 | C16H19N3O |
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1-(4-氨基苯基)-2,3-二氢-1,3,3-三甲基-1H-茚-5-胺 | 5-amino-1-(4'-aminophenyl)-1,3,3-trimethylindane | 54628-89-6 | C18H22N2 |
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1-(4-(苄氧基)-5-甲氧基-2-硝基苯基)乙酮 | 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone | 75665-88-2 | C16H15NO5 |
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1-(4,6-二氯-5-嘧啶基)乙酮 | 1-(4,6-dichloropyrimidin-5-yl)ethanone | 60025-06-1 | C6H4Cl2N2O |
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1-(3’-磺酸苯基)-3-甲基-5-吡唑啉酮 | 1-(3'-sulfophenyl)-3-methyl-5-pyrazolone | 119-17-5 | C10H10N2O4S |
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1-(3-羟基苯基)-2-(甲氨基)乙酮盐酸盐 | 3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride | 94240-17-2 | C9H11NO2*ClH |
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1-(3-甲氧基苯基)乙胺 | 1-(3-methoxy-phenyl)-ethylamine | 62409-13-6 | C9H13NO |
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1-(3-甲基-1-苯基-1H-吡唑-5-基)哌嗪单乙酸盐 | 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate | 906093-30-9 | C2H4O2*C14H18N4 |
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1-(3-甲基-1-苯基-1H-吡唑-5-基)哌嗪 | 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine | 401566-79-8 | C14H18N4 |
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1-(3-溴丙基)-吡咯烷氢溴酸盐 | 1-(3-bromopropyl)pyrrolidine hydrobromide | 88806-08-0 | BrH*C7H14BrN |
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1-(3-氯苯基)甲胺 | 3-chloro-benzylamine; hydrochloride | 42365-42-4 | C7H8ClN*ClH |
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1-(3-氯苯基)-2,2,2-三氟乙醇 | 1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol | 81577-11-9 | C8H6ClF3O |
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1-(3-氯丙基)-4-甲基哌嗪 | 3-(N-methylpiperazinyl)propyl chloride | 104-16-5 | C8H17ClN2 |
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1-(3,5-二甲氧基苯基)戊-1-酮 | 1-(3,5-dimethoxyphenyl)pentan-1-one | 5333-29-9 | C13H18O3 |
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1-(3,4-二甲氧基苯基)-3-甲基-)-3-甲基-1-丁酮 | 1-(3,4-dimethoxyphenyl)-3-methylbutan-1-one | 132858-47-0 | C13H18O3 |
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1-(2-氰基苯基)甲烷磺酰胺 | o-Cyanbenzylsulfonamid | 27350-13-6 | C8H8N2O2S |
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1-(2-氯苯基)乙醇 | 1-(2-chlorphenyl)ethanol | 13524-04-4 | C8H9ClO |
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1-(2-氯-4-吗啉代噻吩并[3,2-D]吡啶-6-基)-N-甲基甲胺 | (2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine | 955979-15-4 | C12H15ClN4OS |
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1-(2-氨基-4-苄氧基-5-甲氧基苯基)乙酮 | 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone | 75665-73-5 | C16H17NO3 |
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1-(2-氨基-3-甲基苯基)乙酮 | 1-(2-amino-3-methylphenyl)ethanone | 53657-94-6 | C9H11NO |
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1-(2-氟-3-羟基-6-硝基苯基)丙烷-2-酮 | 1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one | 649736-31-2 | C9H8FNO4 |
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1-(2-呋喃甲酰基)哌嗪盐酸盐 | 1-<(2-Furanyl)carbonyl>piperazinhydrochlorid | 60548-09-6 | C9H12N2O2*ClH |
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1-(2-吡啶基)哌嗪 | 1-(2-pyridyl)piperazine | 34803-66-2 | C9H13N3 |
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1-(2-二甲基氨基乙基)-1H-5-巯基-四氮唑 | 1-[2-(dimethylamino)ethyl]-1,2-dihydro-5H-tetrazole-5-thione | 61607-68-9 | C5H11N5S |
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1-(2-(3-甲酰基-N-甲基苯甲酰氨基)乙基)哌啶-4-基[1,1'-联苯]-2-基氨基甲酸酯 | biphenyl-2-ylcarbamic acid 1-(2-[(4-formylbenzoyl)methylamino]ethyl)piperidin-4-yl ester | 864760-28-1 | C29H31N3O4 |
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1-(2,4-双(苄氧基)-3,6-二羟基苯基)乙酮 | 1-(2,4-Bis(benzyloxy)-3,6-dihydroxyphenyl)ethanone | 1083181-35-4 | C22H20O5 |
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1-(2,4-二羟基苯基)-2-(4-羟基苯基)-乙酮 | 2,4,4'-trihydroxy deoxybenzoin | 17720-60-4 | C14H12O4 |
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1-(2,3-二氯苯基)哌嗪 | 1-(2,3-dichlorophenyl)-piperazine hydrochloride | 119532-26-2 | C10H12Cl2N2*ClH |
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1-(2,3-二氢-8-羟基-1,4-苯并二氧杂环己-5-基)乙烷-1-酮 | 5-Hydroxy-8-acetyl-benzodioxan-1,4 | 6204-62-2 | C10H10O4 |
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1-(1H-吡咯并[2,3-B]吡啶-5-基)乙酮 | 1-(1H-pyrrolo[2,3-b]pyridin-5-yl)ethanone | 944937-14-8 | C9H8N2O |
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1-(1-(3-甲氧基-4-硝基苯基)哌啶-4-基)-4-甲基哌嗪 | 1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine | 761440-65-7 | C17H26N4O3 |
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1-((苄氧基)羰基)-3-苯基吡咯烷-3-羧酸 | 1-((benzyloxy)carbonyl)-3-phenylpyrrolidine-3-carboxylic acid | 871926-95-3 | C19H19NO4 |
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1-((4'-氯-5,5-二甲基-3,4,5,6-四氢-[1,1'-二苯基]-2-基)甲基)哌嗪 | 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine | 1228780-72-0 | C19H27ClN2 |
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1-(((2R,3S),2-(2,4-二氟苯基)-3-甲基环氧乙烷-2-基)甲基)-1H-1,2,4-三唑 | 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole | 127000-90-2 | C12H11F2N3O |
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1,8-萘磺酸内酯 | 1,8-naphthosultone | 83-31-8 | C10H6O3S |
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1,8-联苄基-1,4,8,11-四氮环十四烷 | 1,8-dibenzyl-1,4,8,11-tetraazacyclotetradecane | 214078-93-0 | C24H36N4 |
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1,7-二氮杂螺[4.4]壬烷-1-羧酸 1,1-二甲基乙酯 | tert-butyl 1,7-diazaspiro[4.4]nonane-1-carboxylate | 885268-47-3 | C12H22N2O2 |
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1,6-二溴萘 | 1,6-dibromonaphthalene | 19125-84-9 | C10H6Br2 |
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1,4-雄二烯-11-beta-醇-3,17-二酮 | (8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione | 898-84-0 | C19H24O3 |
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