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    首页 分子通 按物质功能分类 医药中间体 原料药中间体

    原料药中间体

    原料药中间体是指在药物合成过程中用于生成最终活性成分（即原料药）的化学物质。这些中间体在制药工业中扮演着重要角色，它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能，可以将原料药中间体分为以下几个类别：

    1. 起始物料：这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。

    2. 关键中间体：这些中间体在整个合成过程中起着核心作用，通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。

    3. 保护基团：在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”，防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。

    4. 催化剂和添加剂：虽然不直接形成最终产品，但这些物质能够促进化学反应、提高产率或改善产品的质量特性。

    5. 分离纯化溶剂：这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。

    选择合适的原料药中间体对于保证药物的安全性和有效性至关重要，因此，在其开发过程中需要考虑多个因素，包括成本效益、反应条件的可控性以及环境友好型等方面。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3,20-Bis(ethylenedioxy)pregna-5,7-diene 19592-55-3 C25H36O4
    3,20-Bis(ethylenedioxy)pregna-5,7-diene
    —— [1,1'-Bianthracene]-3,3'-disulfonic acid, 4,4'-diamino-9,9',10,10'-tetrahydro-9,9',10,10'-tetraoxo-, disodium salt 6022-22-6 C28H14N2Na2O10S2
    [1,1'-Bianthracene]-3,3'-disulfonic acid, 4,4'-diamino-9,9',10,10'-tetrahydro-9,9',10,10'-tetraoxo-, disodium salt
    —— 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-YL)thiomethyl]cephalosphoranic acid 30246-33-4 C11H12N4O3S3
    7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-YL)thiomethyl]cephalosphoranic acid
    —— 2,4,6-tris(bromomethyl)-s-triazine 30361-99-0 C6H6Br3N3
    2,4,6-tris(bromomethyl)-s-triazine
    —— (2S,4R,8S,12S)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one 24356-94-3 C29H36O4
    (2S,4R,8S,12S)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
    —— N-Fmoc-(L)-tyrosine methyl ester 1270300-64-5 C25H23NO5
    N-Fmoc-(L)-tyrosine methyl ester
    —— ACP-105 899821-23-9 C16H19ClN2O
    ACP-105
    —— 1-(3-aminophenyl)-2,2,2-trifluoroethanol 17556-38-6 C8H8F3NO
    1-(3-aminophenyl)-2,2,2-trifluoroethanol
    —— 3(2H)-Pyridazinone, 6-(m-methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-, hydrochloride 13299-99-5 C18H24ClN3O3
    3(2H)-Pyridazinone, 6-(m-methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-, hydrochloride
    —— Bromadol HCL BDPC 77239-98-6 C22H28BrNO
    Bromadol HCL BDPC
    —— 5,7,12,14-tetrahydro-5,7,12,14-tetraazapentacene 162039-67-0 C18H14N4
    5,7,12,14-tetrahydro-5,7,12,14-tetraazapentacene
    —— bis-1,3-(4-aminobenzamido)benzene 2362-25-6 C20H18N4O2
    bis-1,3-(4-aminobenzamido)benzene
    —— 5-chloropyridin-3-yl 1H-indole-4-carboxylate 1087243-14-8 C14H9ClN2O2
    5-chloropyridin-3-yl 1H-indole-4-carboxylate
    —— (+/-)-coronaridine 467-77-6 C21H26N2O2
    (+/-)-coronaridine
    —— Cytidine, 2'-deoxy-5-fluoro- 10356-76-0 C9H12FN3O4
    Cytidine, 2'-deoxy-5-fluoro-
    —— 2-fluoro-4-methoxy-1-(trifluoromethyl)benzene 1214344-33-8 C8H6F4O
    2-fluoro-4-methoxy-1-(trifluoromethyl)benzene
    —— ethyl 3-amino-7-bromo-1,6-naphthyridine-2-carboxylate 1620239-76-0 C11H10BrN3O2
    ethyl 3-amino-7-bromo-1,6-naphthyridine-2-carboxylate
    —— 8-Bromo-9-pentofuranosyl-9H-purine-2,6-diol 686300-33-4 C10H11BrN4O6
    8-Bromo-9-pentofuranosyl-9H-purine-2,6-diol
    —— (-)-Tabernemontanine 2134-98-7 C21H26N2O3
    (-)-Tabernemontanine
    —— 2-Fluoro-9-(2,3,5-tri-o-acetylpentofuranosyl)-9h-purin-6-amine 15811-32-2 C16H18FN5O7
    2-Fluoro-9-(2,3,5-tri-o-acetylpentofuranosyl)-9h-purin-6-amine
    —— (±)-2-(methylaminomethyl)-3,4-dihydro-2H-naphthalen-1-one 403860-66-2 C12H15NO
    (±)-2-(methylaminomethyl)-3,4-dihydro-2H-naphthalen-1-one
    —— 3,5-Bis-o-(4-chlorobenzoyl)-2-deoxypentofuranosyl chloride 21740-23-8 C19H15Cl3O5
    3,5-Bis-o-(4-chlorobenzoyl)-2-deoxypentofuranosyl chloride
    —— 4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide 36707-00-3 C13H15N5O6
    4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
    —— (1S,3R,4R,6S,7S)-3-(6-N-benzoyladenin-9-yl)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptane 1197033-19-4 C49H54N7O8P
    (1S,3R,4R,6S,7S)-3-(6-N-benzoyladenin-9-yl)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptane
    —— (1S,3R,4R,6S,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 1197033-22-9 C42H51N4O9P
    (1S,3R,4R,6S,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
    —— (-)-methyl (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-amino-2-hydroxycyclopentanecarboxylate 229615-05-8 C15H28N2O4
    (-)-methyl (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-amino-2-hydroxycyclopentanecarboxylate
    —— 4-Amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxypyrimidin-2-one 37805-90-6 C10H15N3O6
    4-Amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxypyrimidin-2-one
    —— 2'-Chlor-2'-desoxy-Ψ-uridin 4753-04-2 C9H11ClN2O5
    2'-Chlor-2'-desoxy-Ψ-uridin
    —— (S)-methyl-N-(1-phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate 130194-96-6 C16H19NO2
    (S)-methyl-N-(1-phenylethyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate
    —— 4-[(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol 524-63-0 C19H22N2O2
    4-[(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol
    —— (3R,6R)-6-[(1R,3aS,7aR)-4-[2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol 55721-11-4 C27H44O3
    (3R,6R)-6-[(1R,3aS,7aR)-4-[2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
    —— 4-[(S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol 524-63-0 C19H22N2O2
    4-[(S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol
    —— (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanone 1016544-26-5 C16H14BrFO4
    (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanone
    —— (S)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5-carboxylic acid 1262396-32-6 C13H21NO4
    (S)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-5-carboxylic acid
    —— dimethyl diazomethylphosphonate 27491-70-9 C3H8N2O3P
    dimethyl diazomethylphosphonate
    —— N-(tert-butoxycarbonyl)-3-(1-(R)-α-naphthylethyl)-aminopyrrolidine 870859-04-4 C21H28N2O2
    N-(tert-butoxycarbonyl)-3-(1-(R)-α-naphthylethyl)-aminopyrrolidine
    —— Phytonadione epoxide, (E,2S,3R)- 25486-55-9 C31H46O3
    Phytonadione epoxide, (E,2S,3R)-
    —— (R)-2-cyclopropyl-2-hydroxyacetic acid 134624-47-8 C5H8O3
    (R)-2-cyclopropyl-2-hydroxyacetic acid
    —— 1'-([5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl)-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one 1903763-82-5 C23H22F4N4O
    1'-([5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl)-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one
    —— 7-tert-butyl 6-hydrogen (1R,5S,6S)-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-6,7-dicarboxylate 127910-62-7 C13H21NO6
    7-tert-butyl 6-hydrogen (1R,5S,6S)-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-6,7-dicarboxylate
    —— 2,6-bis(3-isopropylphenyl)benzaldehyde 934334-00-6 C25H26O
    2,6-bis(3-isopropylphenyl)benzaldehyde
    —— 1-(6-bromo-pyridin-2-yl)-3-carboethoxy-thiourea 1010120-59-8 C9H10BrN3O2S
    1-(6-bromo-pyridin-2-yl)-3-carboethoxy-thiourea
    —— 5-tert-butylbenzo<b>thiophene-2-carboxylic acid 126231-21-8 C13H14O2S
    5-tert-butylbenzo<b>thiophene-2-carboxylic acid
    —— vimseltinib 1628606-05-2 C23H25N7O2
    vimseltinib
    —— Cholesterylsulfat 1256-86-6 C27H46O4S
    Cholesterylsulfat
    —— 2-[Carbamoyl-[(5-nitrofuran-2-yl)methylideneamino]amino]acetic acid 63981-22-6 C8H8N4O6
    2-[Carbamoyl-[(5-nitrofuran-2-yl)methylideneamino]amino]acetic acid
    —— 1-(2,4-dihydroxyphenyl)-3-(4-methylphenyl) propenone 36574-88-6 C16H14O3
    1-(2,4-dihydroxyphenyl)-3-(4-methylphenyl) propenone
    —— cis-(3H,9aH)-3-Ethoxycarbonyl-chinolizidin 19728-77-9 C12H21NO2
    cis-(3H,9aH)-3-Ethoxycarbonyl-chinolizidin
    —— (+/-)-(9a<i>r</i>)-octahydro-quinolizin-3<i>c</i>-carboxylic acid ethyl ester 19728-76-8 C12H21NO2
    (+/-)-(9a<i>r</i>)-octahydro-quinolizin-3<i>c</i>-carboxylic acid ethyl ester
    —— (2S,5R)-7-oxo-N-[(4R)-azepan-4-yl]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 1174019-01-2 C13H22N4O6S
    (2S,5R)-7-oxo-N-[(4R)-azepan-4-yl]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide