原料药中间体是指在药物合成过程中用于生成最终活性成分(即原料药)的化学物质。这些中间体在制药工业中扮演着重要角色,它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能,可以将原料药中间体分为以下几个类别:
起始物料:这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。
关键中间体:这些中间体在整个合成过程中起着核心作用,通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。
保护基团:在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”,防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。
催化剂和添加剂:虽然不直接形成最终产品,但这些物质能够促进化学反应、提高产率或改善产品的质量特性。
分离纯化溶剂:这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。
选择合适的原料药中间体对于保证药物的安全性和有效性至关重要,因此,在其开发过程中需要考虑多个因素,包括成本效益、反应条件的可控性以及环境友好型等方面。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| 2-氟-6-羟基苯甲酸甲酯 | methyl 2-fluoro-6-hydroxybenzoate | 72373-81-0 | C8H7FO3 |
| 2-氟-6-硝基-N-苯基苯甲酰胺 | 2-fluoro-6-nitro-N-phenylbenzamide | 870281-83-7 | C13H9FN2O3 |
| 2-氟-6-甲氧基-4-溴苯甲腈 | 4-bromo-2-fluoro-6-methoxybenzonitrile | 457051-15-9 | C8H5BrFNO |
| 2-氟-6-甲基苯甲酸 | 2-fluoro-6-methylbenzoic acid | 90259-27-1 | C8H7FO2 |
| 2-氟-6-(1-三苯甲基-1H-咪唑-4-基)苯甲醛 | 2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde | 1402838-09-8 | C29H21FN2O |
| 2-氟-5甲氧基-4-硝基苯甲酸 | 2-fluoro-5-methoxy-4-nitrobenzoic acid | 1001345-80-7 | C8H6FNO5 |
| 2-氟-5-甲烷磺酰基苯甲酸 | 2-fluoro-5-methanesulfonylbenzoic acid | 247569-56-8 | C8H7FO4S |
| 2-氟-5-甲基苯甲酸 | 2-fluoro-5-methyl-benzoic acid | 321-12-0 | C8H7FO2 |
| 2-氟-5-(三氟甲氧基)苄胺 | (2-fluoro-5-(trifluoromethoxy)phenyl)methanamine | 886498-13-1 | C8H7F4NO |
| 2-氟-4-三氟甲氧基苯甲醛 | 2-fluoro-4-(trifluoromethoxy)benzaldehyde | 1227628-83-2 | C8H4F4O2 |
| 2-氟-3-胺基苯甲醚 | methyl 3-amino-2-fluorobenzoate | 1195768-18-3 | C8H8FNO2 |
| 2-氟-2',3',5'-三氧乙酰基腺苷 | 2',3',5'-Tri-O-acetyl-2-fluor-adenosin | 15811-32-2 | C16H18FN5O7 |
| 2-巯基乙酸叔丁酯 | t-butyl mercaptoacetate | 20291-99-0 | C6H12O2S |
| 2-巯基-N-甲基苯甲酰胺 | 2-mercapto-N-methylbenzamide | 20054-45-9 | C8H9NOS |
| 2-巯基-4-甲基-5-噻唑乙酸 | 2-mercapto-4-methyl-5-thiazoleacetic acid | 34272-64-5 | C6H7NO2S2 |
| 2-巯基-4-(4-吡啶基)噻唑 | 2-mercapto-4-(4-pyridyl)thiazole | 77168-63-9 | C8H6N2S2 |
| 2-四氢呋喃甲酸 | tetrahydro-2-furancarboxylic acid | 16874-33-2 | C5H8O3 |
| 2-哌嗪甲醇双盐酸盐 | Piperazin-2-ylmethanol dihydrochloride | 122323-87-9 | C5H14Cl2N2O |
| 2-吡啶丁酸 | 4-(pyridin-2-yl)butanoic acid | 102879-51-6 | C9H11NO2 |
| 2-吡啶-2-基吡啶-4-胺 | 4-amino-2,2'-bipyridine | 14151-21-4 | C10H9N3 |
| 2-亚甲基戊二酸二甲酯 | dimethyl 2-methylenepentanedioate | 5621-44-3 | C8H12O4 |
| 2-二甲基氨基-2-苯基丁-1-醇 | 2-phenyl-2-dimethylamino-1-butanol | 39068-94-5 | C12H19NO |
| 2-乙酰氨甲基-4-(4-氟苄基)吗啉 | 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine | 112913-94-7 | C14H19FN2O2 |
| 2-乙酰氨基-3,6-二-o-苄基-2-脱氧-beta-d-吡喃葡萄糖苷苄酯 | N-[(2R,3S,4R,5S)-5-hydroxy-2,4-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-3-yl]acetamide | 62867-63-4 | C29H33NO6 |
| 2-乙酰基噻唑-5-羧酸甲酯 | methyl-2-acetylthiazole-5-carboxylate | 1261080-59-4 | C7H7NO3S |
| 2-乙酰基-6-溴萘 | 1-(6-bromonaphthalen-2-yl)ethanone | 1590-25-6 | C12H9BrO |
| 2-乙硫基-6,7-二氟-4-羟基喹啉-3-羧酸乙酯 | ethyl 4-hydroxy-6,7-difluoro-2-(ethylthio)quinoline-3-carboxylate | 154330-67-3 | C14H13F2NO3S |
| 2-乙烯基-N,N-二甲基苄胺 | N,N-dimethylaminomethylstyrene | 22826-55-7 | C11H15N |
| 2-乙炔-6-甲基吡啶 | 2-ethynyl-6-methylpyridine | 30413-58-2 | C8H7N |
| 2-乙氧羰基氨基-5-(4-氟苄基氨基)硝基苯 | 2-ethoxycarbonylamino-5-(4-fluorobenzylamino)nitrobenzene | 150812-23-0 | C16H16FN3O4 |
| 2-乙氧基-1-[[(2’-(1H-四唑-5-基)联苯-4-基)甲基]苯并咪唑]-7-甲酸乙酯 | methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate | 139481-69-9 | C25H22N6O3 |
| 2-乙氧基-1-[[(2'-腈基连苯-4-取代)甲基]苯并咪唑]-7-羧酸乙酯 | ethyl-2-ethoxy-1-[[(2'-cyanobiphenyl-4-yl) methyl]benzimidazole]-7-carboxylate | 139481-41-7 | C26H23N3O3 |
| 2-乙基苯并呋喃 | 2-ethylbenzofuran | 3131-63-3 | C10H10O |
| 2-乙基丙烯酰氯 | 2-ethylacryloyl chloride | 4390-96-9 | C5H7ClO |
| 2-乙基-4--10H-噻吩并苯并二氮卓 | 2-ethyl-4-(4-methyl-piperazin-1-yl)-10<i>H</i>-benzo[<i>b</i>]thieno[2,3-<i>e</i>][1,4]diazepine | 61325-71-1 | C18H22N4S |
| 2-丙基-4,5-咪唑二羧酸二甲酯 | 2-propyl-4,5-bis(methoxycarbonyl)-imidazole | 124750-59-0 | C10H14N2O4 |
| 2-丁基辛酸 | 2-butyloctanoic acid | 27610-92-0 | C12H24O2 |
| 2-丁基苯并呋喃 | 2-n-butylbenzo[b]furan | 4265-27-4 | C12H14O |
| 2-[[4-(2,6-二氯-4-硝基苯基)偶氮苯基]-(2-甲氧羰基氧基乙基)氨基]乙基甲基碳酸酯 | 2,4,10-Trioxa-7-azaundecan-11-oic acid, 7-[4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]-3-oxo-, methyl ester | 10347-09-8 | C20H20Cl2N4O8 |
| 2-[[(4-甲氧基-3-甲基-2-吡啶基)甲基]硫基]-6-(1H-吡咯-1-基)-1H-苯并咪唑 | ilaprazole sulfide | 172152-35-1 | C19H18N4OS |
| 2-[[(3aR,4S,6R,6aS)-6-[[5-氨基-6-氯-2-(丙硫基)-4-嘧啶基]氨基]四氢-2,2-二甲基-4H-环戊烯并-1,3-二恶茂-4-基]氧基]乙醇 | 2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol | 376608-74-1 | C17H27ClN4O4S |
| 2-[[(3AR,4S,6R,6AS)-6-氨基四氢-2,2-二甲基-4H-环戊并-1,3-二恶茂-4-基]氧基]-乙醇 (2R,3R)-2,3-二羟基丁二酸盐 | 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol L-tartrate | 376608-65-0 | C4H6O6*C10H19NO4 |
| 2-[4-[(4-氯苯基)苯基甲基]哌嗪-1-基]乙醇 | 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol | 109806-71-5 | C19H23ClN2O |
| 2-[4,5-二(1,3,2-二硫杂砷戊环-2-基)-6-羟基-3-氧代-3H-氧杂蒽-9-基]苯甲酸 | 4'5'-bis(1,2,3-dithioarsolan-2-yl)-fluorescein | 212118-77-9 | C24H18As2O5S4 |
| 2-[2-[2-(2-苯基甲氧基乙氧基)乙氧基]乙氧基]乙醇4-甲基苯磺酸酯 | 2,5,8,11-Tetraoxatridecan-13-ol, 1-phenyl-, 4-methylbenzenesulfonate | 89346-82-7 | C22H32O8S |
| 2-[2-(苯硫基)苯基]乙酸 | 2-[2-(phenylsulfanyl)phenyl]acetic acid | 1527-17-9 | C14H12O2S |
| 2-[2-(乙烯基氧基)乙氧基]异吲哚啉-1,3-二酮 | 2-(2-vinyloxy-ethoxy)-isoindole-1,3-dione | 391212-30-9 | C12H11NO4 |
| 2-[2-(3-甲氧基苯基)乙基]苯酚 | 2-[2-(3-methoxyphenyl)ethyl]phenol | 167145-13-3 | C15H16O2 |
| 2-[2-(2-氨乙氧基)乙氧基]乙醇 | 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol | 6338-55-2 | C6H15NO3 |
| 2-[1-(乙基磺酰基)-3-氮杂环丁亚基]乙腈 | 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile | 1187595-85-2 | C7H10N2O2S |