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    首页 分子通 按物质功能分类 医药中间体 原料药中间体

    原料药中间体

    原料药中间体是指在药物合成过程中用于生成最终活性成分（即原料药）的化学物质。这些中间体在制药工业中扮演着重要角色，它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能，可以将原料药中间体分为以下几个类别：

    1. 起始物料：这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。

    2. 关键中间体：这些中间体在整个合成过程中起着核心作用，通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。

    3. 保护基团：在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”，防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。

    4. 催化剂和添加剂：虽然不直接形成最终产品，但这些物质能够促进化学反应、提高产率或改善产品的质量特性。

    5. 分离纯化溶剂：这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。

    选择合适的原料药中间体对于保证药物的安全性和有效性至关重要，因此，在其开发过程中需要考虑多个因素，包括成本效益、反应条件的可控性以及环境友好型等方面。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— {[(Z)-(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphate 1075198-30-9 C12H19F6N4O4P
    {[(Z)-(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphate
    —— Intermediate of Clarithromycin 119665-62-2 C49H96N2O14Si2
    Intermediate of Clarithromycin
    —— 7-[2-(3,3-Difluoro-4-phenoxybut-1-EN-1-YL)-3,5-dihydroxycyclopentyl]hept-5-enoic acid 209860-88-8 C22H28F2O5
    7-[2-(3,3-Difluoro-4-phenoxybut-1-EN-1-YL)-3,5-dihydroxycyclopentyl]hept-5-enoic acid
    —— 5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one 156732-13-7 C32H32N2O
    5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
    —— (S)-1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)-phenyl)propanol 142569-70-8 C29H28ClNO2
    (S)-1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)-phenyl)propanol
    —— Ethyl 2-(pyrrolidin-3-yloxy)benzoate hydrochloride 1220032-96-1 C13H18ClNO3
    Ethyl 2-(pyrrolidin-3-yloxy)benzoate hydrochloride
    —— N-BOC-3-PIPERIDINE methylaCETATE 934342-38-8 C13H23NO4
    N-BOC-3-PIPERIDINE methylaCETATE
    —— 3-Fluoroquinoline-4-carbaldehyde 1261269-78-6 C10H6FNO
    3-Fluoroquinoline-4-carbaldehyde
    —— Gozetotide 1366302-52-4 C44H62N6O17
    Gozetotide
    —— Tetrabromophthalic acid, sodium salt 25357-79-3 C8H2Br4NaO4+
    Tetrabromophthalic acid, sodium salt
    —— 1, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride 17070-45-0 C19H22Cl3N3O
    1, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride
    —— Demeclocycline 127-33-3 C21H21ClN2O8
    Demeclocycline
    —— 4-Nitrophenyl 2-(furfurylsulfinyl)acetic acid 123855-55-0 C13H11NO6S
    4-Nitrophenyl 2-(furfurylsulfinyl)acetic acid
    —— 2-(Methoxycarbonyl)-1,4-phenylene bis[6-({[4-(acryloyloxy)butoxy]carbonyl}oxy)-2-naphthoate] 914918-26-6 C46H40O16
    2-(Methoxycarbonyl)-1,4-phenylene bis[6-({[4-(acryloyloxy)butoxy]carbonyl}oxy)-2-naphthoate]
    —— 2,2,2-Trifluoro-1-(4-methylpyridin-2-yl)ethanone 1060804-97-8 C8H6F3NO
    2,2,2-Trifluoro-1-(4-methylpyridin-2-yl)ethanone
    —— 6-(4-{(E)-2-[4-(Hexane-1-sulfonyl)-phenyl]-vinyl}-phenoxy)-hexan-1-ol 133261-44-6 C26H36O4S
    6-(4-{(E)-2-[4-(Hexane-1-sulfonyl)-phenyl]-vinyl}-phenoxy)-hexan-1-ol
    —— 6-O-Methyl-2',4''-bis-O-(trimethylsilyl)-9-[O-(1-ethoxy-1-methylethyl)oxime] Erythromycin 119665-62-2 C49H96N2O14Si2
    6-O-Methyl-2',4''-bis-O-(trimethylsilyl)-9-[O-(1-ethoxy-1-methylethyl)oxime] Erythromycin
    —— 4-hydrazino-2-(trifluoromethyl)pyridine 1228535-68-9 C6H6F3N3
    4-hydrazino-2-(trifluoromethyl)pyridine
    —— 1-chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-α-D-ribose 21740-23-8 C19H15Cl3O5
    1-chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-α-D-ribose
    —— [(2R,3R,5S)-5-chloro-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate 21740-23-8 C19H15Cl3O5
    [(2R,3R,5S)-5-chloro-3-(4-chlorobenzoyl)oxyoxolan-2-yl]methyl 4-chlorobenzoate
    —— Diethylethoxyammonium chloride 13989-32-7 C6H15ClNO-
    Diethylethoxyammonium chloride
    —— (+)-Camphor Bromide 10293-06-8 C10H15BrO
    (+)-Camphor Bromide
    —— N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl} methanesulfonamide maleate 1640292-55-2 C4H4O4*C15H23N5O2S
    N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl} methanesulfonamide maleate
    —— (3R,4S)-1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)pyrrolidine-3-carboxylic acid 252919-44-1 C13H21NO6
    (3R,4S)-1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)pyrrolidine-3-carboxylic acid
    —— (4R,6R,8S,9S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one 24356-94-3 C29H36O4
    (4R,6R,8S,9S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
    —— tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride 1190890-12-0 C10H20N2O2*ClH
    tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride
    —— (1S,3R,4R,6S,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-3-(5-methyl-4-N-benzoylcytosin-1-yl)-2,5-dioxa-bicyclo[2.2.1]heptane 1197033-17-2 C49H56N5O9P
    (1S,3R,4R,6S,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-3-(5-methyl-4-N-benzoylcytosin-1-yl)-2,5-dioxa-bicyclo[2.2.1]heptane
    —— (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(4S,6S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(4R,5R,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one 13127-18-9 C37H68N2O13
    (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(4S,6S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(4R,5R,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
    —— Prop-2-en-1-yl D-threo-hexopyranuronate 188717-04-6 C9H14O7
    Prop-2-en-1-yl D-threo-hexopyranuronate
    —— Belumosudil Mesylate 2109704-99-4 C27H28N6O5S
    Belumosudil Mesylate
    —— 1-(1-(2-(Trifluoromethyl)phenyl)cyclopropyl)piperazine hydrochloride 1245643-43-9 C14H18ClF3N2
    1-(1-(2-(Trifluoromethyl)phenyl)cyclopropyl)piperazine hydrochloride
    —— (6R,7R)-7-Amino-3-(imidazo[1,2-b]pyridazin-1(5H)-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydroiodide 197897-11-3 C14H16IN5O3S
    (6R,7R)-7-Amino-3-(imidazo[1,2-b]pyridazin-1(5H)-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydroiodide
    —— (3aR,4R,5R,6aS)-4-(3,3-Difluoro-4-phenoxybut-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate 209861-00-7 C24H22F2O5
    (3aR,4R,5R,6aS)-4-(3,3-Difluoro-4-phenoxybut-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate
    —— 2-(Azetidin-3-yl)-6-fluoropyridine dihydrochloride 1260828-79-2 C8H11Cl2FN2
    2-(Azetidin-3-yl)-6-fluoropyridine dihydrochloride
    —— morellin 1183-12-6 C33H36O7
    morellin
    —— Methyl 2-(6-(trifluoromethyl)pyridin-3-YL)acetate 1363210-38-1 C9H8F3NO2
    Methyl 2-(6-(trifluoromethyl)pyridin-3-YL)acetate
    —— Ethyl N-acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosinate 30804-52-5 C19H17I4NO5
    Ethyl N-acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosinate
    —— (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine maleic acid salt 59469-29-3 2C4H4O4*C16H15ClFN3
    (7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine maleic acid salt
    —— PEG-biotincap-ATB-BMPA 207971-25-3 C46H70F3N7O19S
    PEG-biotincap-ATB-BMPA
    —— 6,7-Dichloro-4-methyl-2H-1-benzopyran-2-one 923019-32-3 C10H6Cl2O2
    6,7-Dichloro-4-methyl-2H-1-benzopyran-2-one
    —— 4-Methyl-8-(propan-2-yl)-2H-1-benzopyran-2-one 923019-31-2 C13H14O2
    4-Methyl-8-(propan-2-yl)-2H-1-benzopyran-2-one
    —— 3-Bromo-N-cyclopropyl-2-nitroaniline 1396554-46-3 C9H9BrN2O2
    3-Bromo-N-cyclopropyl-2-nitroaniline
    —— tert-Butyl 3-oxo-5,7-dihydro-2H-pyrrolo[3,4-c]pyridazine-6(3H)-carboxylate 1395493-25-0 C11H15N3O3
    tert-Butyl 3-oxo-5,7-dihydro-2H-pyrrolo[3,4-c]pyridazine-6(3H)-carboxylate
    —— 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[(S)-carboxy(3,4-dihydroxyphenyl)methoxy]imino]acetyl]amino]-8-oxo-, (6R,7R)- 117211-03-7 C20H17N5O9S2
    5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[[(S)-carboxy(3,4-dihydroxyphenyl)methoxy]imino]acetyl]amino]-8-oxo-, (6R,7R)-
    —— 2-(Fluoromethyl)cyclohexane-1-carboxylic acid 1421603-44-2 C8H13FO2
    2-(Fluoromethyl)cyclohexane-1-carboxylic acid
    —— (E)-but-2-enedioic acid;[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine 59469-29-3 C24H23ClFN3O8
    (E)-but-2-enedioic acid;[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine
    —— 9-(β-<i>D</i>-2,3-anhydro-lyxofuranosyl)-1,9-dihydro-purin-6-one 31766-13-9 C10H10N4O4
    9-(β-<i>D</i>-2,3-anhydro-lyxofuranosyl)-1,9-dihydro-purin-6-one
    —— (2S)-N-(3-Amino-2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide 247061-08-1 C17H27N3O
    (2S)-N-(3-Amino-2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
    —— SHR-1258 dimaleate 1397922-61-0 C40H39ClN6O11
    SHR-1258 dimaleate
    —— Rabacfosadine Succinate 1431856-99-3 C4H6O4*C21H35N8O6P
    Rabacfosadine Succinate