原料药中间体是指在药物合成过程中用于生成最终活性成分(即原料药)的化学物质。这些中间体在制药工业中扮演着重要角色,它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能,可以将原料药中间体分为以下几个类别:
起始物料:这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。
关键中间体:这些中间体在整个合成过程中起着核心作用,通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。
保护基团:在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”,防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。
催化剂和添加剂:虽然不直接形成最终产品,但这些物质能够促进化学反应、提高产率或改善产品的质量特性。
分离纯化溶剂:这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。
选择合适的原料药中间体对于保证药物的安全性和有效性至关重要,因此,在其开发过程中需要考虑多个因素,包括成本效益、反应条件的可控性以及环境友好型等方面。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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2'-脱氧-5-[3-[(三氟乙酰基)氨基]-1-丙炔基]胞苷 | 5-[3-(2,2,2-trifluoroacetamido)-prop-1-ynyl]-2'-deoxycytidine | 115899-38-2 | C14H15F3N4O5 |
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2'-碘-2'-脱氧尿苷 | 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-iodotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 4753-03-1 | C9H11IN2O5 |
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2'-溴-2'-脱氧-D-尿苷 | 2'-bromo-2'-deoxyuridine | 4753-02-0 | C9H11BrN2O5 |
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2'-氯-4',5'-二氟苯乙酮 | 2'-chloro-4',5'-difluoroacetophenone | 121872-94-4 | C8H5ClF2O |
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2'-氯-2'-脱氧尿苷 | 2'-chloro-2'-deoxyuridine | 4753-04-2 | C9H11ClN2O5 |
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2'-O-(2-甲氧基乙基)胞苷 | 2'-O-(2-methoxyethyl)cytidine | 223777-16-0 | C12H19N3O6 |
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2',4'-二羟基-2-苯基苯乙酮 | 1-(2,4-dihydroxyphenyl)-2-phenylethanone | 3669-41-8 | C14H12O3 |
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2',3'-脱水肌苷 | 9-[(2R,4R,5R)-4-(Hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-YL]-1H-purin-6-one | 31766-13-9 | C10H10N4O4 |
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2',3'-O-(甲氧基亚甲基)尿苷5'-(4-氯苯基)磷酸酯 | Mmucpp | 93134-82-8 | C17H18ClN2O10P |
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2 - (4 - 甲氧基苯基)丙酸乙酯 | methyl 2-(4-methoxyphenyl)propionate | 50415-73-1 | C11H14O3 |
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1H-苯并三唑甲酸 | 1h-benzotriazole-5-carboxylic acid | 60932-58-3 | C7H5N3O2 |
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1E-茚满-1-酮肟 | (E)-indan-1-one oxime | 68253-35-0 | C9H9NO |
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18-羟基十八烷酸 | 18-hydroxystearic acid | 3155-42-8 | C18H36O3 |
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17β-羟基雌甾-4,9-二烯-3-酮 | 17β-hydroxyestra-4,9-dien-3-one | 6218-29-7 | C18H24O2 |
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17α-二氢马烯雌酮 | 17alpha-Dihydroequilin | 651-55-8 | C18H22O2 |
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17-苯基-18,19,20-三去甲前列腺素E2 | 17-phenyl-ω-trinor prostaglandin E<sub>2</sub> | 38315-43-4 | C23H30O5 |
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17-羟基孕甾-4,9(11)-二烯-3,20-二酮17-乙酸酯 | 17-acetoxy-pregna-4,9(11)-diene-3,20-dione | 5106-48-9 | C23H30O4 |
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17-氰基-9,17-二羟基雄甾-4-烯-3-酮 | 17β-Cyano-9α,17α-dihydroxyandrost-4-en-3-one | 116256-35-0 | C20H27NO3 |
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17-氧代地塞米松 | 9α-fluoro-androsta-1,4-diene-11β-hydroxy-16α-methyl-3,17-dione | 1880-61-1 | C20H25FO3 |
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17-乙酰氧基-5a-雄甾-2,16-二烯 | 17-acetoxy-5α-androsta-2,16-diene | 50588-42-6 | C21H30O2 |
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16,16-二甲基前列腺素E2 | 16,16-dimethyl-PGE<sub>2</sub> | 39746-25-3 | C22H36O5 |
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14-羟孕酮 | Pregn-4-ene-3,20-dione, 14-hydroxy- | 16031-66-6 | C21H30O3 |
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13beta-乙基-15alpha-羟基甾烷-4-烯-3,17-二酮 | 15α-Hydroxy-18-methyl-4-estren-3,17-dion | 60919-46-2 | C19H26O3 |
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13-顺式-阿维 A | 13-cis-Acitretin | 69427-46-9 | C21H26O3 |
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13,14-二氢-15-酮前列腺素e2 | 13,14-dihydro-15-keto PGE<sub>2</sub> | 363-23-5 | C20H32O5 |
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13,14-二氢-15-酮前列腺素d2 | 13,14,-dihydro-15-keto prostaglandin D<sub>2</sub> | 59894-07-4 | C20H32O5 |
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13,14-二氢-15-氧代前列腺素 F2alpha | 13,14-dihydro-15-keto-prostaglandin F<sub>2α</sub> | 27376-76-7 | C20H34O5 |
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11a-羟基坎利酮丙烯酸甲酯 | 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone | 192704-56-6 | C24H32O6 |
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11Alpha-孕酮醋酸盐 | 11α-acetoxyprogesterone | 2268-98-6 | C23H32O4 |
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11Alpha-孕酮 | 11-alpha-hydroxyprogesterone | 80-75-1 | C21H30O3 |
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10beta-羟基D-(-)-炔诺孕酮 | 13β-ethyl-17α-ethynyl-10β,17β-dihydroxy-4-en-3-one | 21508-50-9 | C21H28O3 |
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10-甲氧基亚氨基芪 | 10-methoxy-5H-dibenzo[b,f]azepine | 4698-11-7 | C15H13NO |
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10-(1-萘基)蒽-9-硼酸 | (10-(naphthalen-1-yl)anthracen-9-yl)boronic acid | 400607-46-7 | C24H17BO2 |
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10,11-二氢-5H-二苯并[b,f]氮杂革-10-酮 | 5H-dibenzo[b,f]azepin-10(11H)-one | 21737-58-6 | C14H11NO |
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1-萘基二氯磷酸酯 | 1-naphthyl dichlorophosphate | 31651-76-0 | C10H7Cl2O2P |
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1-苯磺酰基吡咯并吡啶-3-硼酸酯 | 1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine | 886547-94-0 | C19H21BN2O4S |
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1-苯基-2-丁炔-1-酮 | 1-phenyl-2-butyn-1-one | 6710-62-9 | C10H8O |
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1-苯基-1H-咪唑-5-羧酸乙酯 | ethyl 1-phenyl-1H-imidazole-5-carboxylate | 80304-52-5 | C12H12N2O2 |
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1-苯基-1H-咪唑-5-羧酸 | 3-phenylimidazole-4-carboxylic acid | 135417-65-1 | C10H8N2O2 |
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1-苯基-1,2,3,4-四氢异喹啉 | 1-phenyl-1,2,3,4-tetrahydroisoquinoline | 22990-19-8 | C15H15N |
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1-苊酮 | 1(2H)-acenaphthylenone | 2235-15-6 | C12H8O |
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1-苄氧羰基-3-甲基咪唑三氟甲磺酸盐 | N-benzyloxycarbonyl-N'-methylimidazolium triflate | 163080-99-7 | CF3O3S*C12H13N2O2 |
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1-苄基吡咯烷-3-羧酸甲酯盐酸盐 | Methyl 1-benzylpyrrolidine-3-carboxylate hydrochloride | 1087209-93-5 | C13H17NO2*ClH |
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1-苄基吡咯烷-2,5-二酮 | 1-(phenylmethyl)-2,5-pyrrolidinedione | 2142-06-5 | C11H11NO2 |
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1-苄基2-甲基(2S)-5-氧哌啶-1,2-二羧酸酯 | 1-benzyl 2-methyl (2S)-5-oxopiperidine-1,2-dicarboxylate | 117836-13-2 | C15H17NO5 |
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1-苄基-4-哌啶甲醇 | 1-benzyl-4-piperidinemethanol | 67686-01-5 | C13H19NO |
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1-苄基-4-哌啶甲酸甲酯 | methyl 1-benzylpiperidine-4-carboxylate | 10315-06-7 | C14H19NO2 |
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1-苄基-3-哌啶醇 | 1-benzyl-3-hydroxypiperidine | 14813-01-5 | C12H17NO |
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1-苄基-3-吡咯烷酮 | 1-benzyl-pyrrolid-3-one | 775-16-6 | C11H13NO |
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1-苄基-2-氧代哌嗪 | 1-benzyl-piperazin-2-one | 59702-21-5 | C11H14N2O |
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