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    首页 分子通 按物质功能分类 医药中间体 原料药中间体

    原料药中间体

    原料药中间体是指在药物合成过程中用于生成最终活性成分（即原料药）的化学物质。这些中间体在制药工业中扮演着重要角色，它们通过一系列化学反应逐步转化成成品药物。根据其在生产过程中的位置和功能，可以将原料药中间体分为以下几个类别：

    1. 起始物料：这类中间体是最初用于合成最终产品的原材料。它们通常来源于天然产物、化工产品或其他已经存在的化合物。

    2. 关键中间体：这些中间体在整个合成过程中起着核心作用，通常是通过复杂的化学反应得到的。它们对于确保原料药的质量和成本效益至关重要。

    3. 保护基团：在药物合成中使用这类中间体是为了对某些敏感部分进行临时性或选择性的“保护”，防止它们在不必要的位置上发生副反应。保护完成后可通过特定条件去除这些保护基。

    4. 催化剂和添加剂：虽然不直接形成最终产品，但这些物质能够促进化学反应、提高产率或改善产品的质量特性。

    5. 分离纯化溶剂：这类中间体主要用于原料药合成过程中的提纯步骤。它们帮助从目标产物中去除杂质并提高产品的纯度。

    选择合适的原料药中间体对于保证药物的安全性和有效性至关重要，因此，在其开发过程中需要考虑多个因素，包括成本效益、反应条件的可控性以及环境友好型等方面。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-Amino-4-(trifluoromethyl)cyclohexan-1-ol hydrochloride 1803606-71-4 C7H13ClF3NO
    4-Amino-4-(trifluoromethyl)cyclohexan-1-ol hydrochloride
    —— bis[2-bromo-5-(2-methoxyethoxy)phenyl]acetylene 388111-07-7 C20H20Br2O4
    bis[2-bromo-5-(2-methoxyethoxy)phenyl]acetylene
    —— N,N'-bis(2,3-diacetoxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide 174416-65-0 C24H28I3N3O11
    N,N'-bis(2,3-diacetoxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
    —— tert-Butyl (1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate 2306246-27-3 C12H21NO3
    tert-Butyl (1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate
    —— 3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate 1194836-75-3 C25H32F3N3O5
    3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
    —— 17β-Acetoxyestra-4,6-dien-3-on 2590-41-2 C20H26O3
    17β-Acetoxyestra-4,6-dien-3-on
    —— O-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-2-[6-(2-methylpropanoylamino)purin-9-yl]oxolan-3-yl] 1,1-dioxo-1,4-thiazinane-4-carbothioate 1219089-85-6 C40H44N6O9S2
    O-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-2-[6-(2-methylpropanoylamino)purin-9-yl]oxolan-3-yl] 1,1-dioxo-1,4-thiazinane-4-carbothioate
    —— endo-BCN-PEG2-Biotin 1393600-24-2 C27H42N4O6S
    endo-BCN-PEG2-Biotin
    —— 4-N-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 2-cyanoethyl N,N-diisopropylphosphoramidite 157327-96-3 C46H52N5O8P
    4-N-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 2-cyanoethyl N,N-diisopropylphosphoramidite
    —— tert-butyl (3,3-bis(hydroxymethyl)cyclobutyl)carbamate 1639838-86-0 C11H21NO4
    tert-butyl (3,3-bis(hydroxymethyl)cyclobutyl)carbamate
    —— 4-aminocyclohexanesulfonic acid 146764-47-8 C6H13NO3S
    4-aminocyclohexanesulfonic acid
    —— (2R,3R,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-(2-(2-(((benzyloxy)carbonyl)amino)ethoxy)ethoxy)tetrahydro-2H-pyran-3,4-diyl diacetate 1261568-35-7 C26H36N2O12
    (2R,3R,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-(2-(2-(((benzyloxy)carbonyl)amino)ethoxy)ethoxy)tetrahydro-2H-pyran-3,4-diyl diacetate
    —— 1-O-methyl-2-deoxy-2-fluoro-3,5-O,O-dibenzyl-D-ribose 863642-44-8 C20H23FO4
    1-O-methyl-2-deoxy-2-fluoro-3,5-O,O-dibenzyl-D-ribose
    —— 2,6-bis[1-((2,6-diethylphenyl)imino)ethyl]pyridine 420119-94-4 C29H35N3
    2,6-bis[1-((2,6-diethylphenyl)imino)ethyl]pyridine
    —— 7α-Hydroxy-3-keto-Δ<sup>4</sup>-cholensaeure 14772-95-3 C24H36O4
    7α-Hydroxy-3-keto-Δ<sup>4</sup>-cholensaeure
    —— Tucatinib hemiethanolate 1429755-56-5 C54H54N16O5
    Tucatinib hemiethanolate
    —— tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate 1057341-65-7 C12H22INO4
    tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate
    —— Cis-4-Aminocyclohexanol 6850-65-3 C6H13NO
    Cis-4-Aminocyclohexanol
    —— 4727-41-7 C4H8O2S
    —— 2-Methyl-2-propanyl (2S)-2-({[(2-methyl-2-propanyl)(diphenyl)silyl]oxy}methyl)-5-oxo-1-pyrrolidinecarboxylate 138871-56-4 C26H35NO4Si
    2-Methyl-2-propanyl (2S)-2-({[(2-methyl-2-propanyl)(diphenyl)silyl]oxy}methyl)-5-oxo-1-pyrrolidinecarboxylate
    —— 2,3-Diaminobenzoate 603-81-6 C7H7N2O2-
    2,3-Diaminobenzoate
    —— 3-(3-bromophenyl)-2-oxopropanoic acid 207910-90-5 C9H7BrO3
    3-(3-bromophenyl)-2-oxopropanoic acid
    —— Unii-3LM5SX2N4X 868171-91-9 C50H86O35P4
    Unii-3LM5SX2N4X
    —— ((2S,5R)-5-aminotetrahydro-2H-pyran-2-yl)methanol 1398569-79-3 C6H13NO2
    ((2S,5R)-5-aminotetrahydro-2H-pyran-2-yl)methanol
    —— 3'-O-Bis(p-methoxyphenyl)phenylmethyl-9-(S)-(2,3-dihydroxypropyl)-N<sup>6</sup>-benzoyladenine 115196-70-8 C36H33N5O5
    3'-O-Bis(p-methoxyphenyl)phenylmethyl-9-(S)-(2,3-dihydroxypropyl)-N<sup>6</sup>-benzoyladenine
    —— (-)-3-(trifluoroacetyl)camphor 207742-84-5 C12H15F3O2
    (-)-3-(trifluoroacetyl)camphor
    —— N-Boc-exo-3-aminotropane 744183-20-8 C12H22N2O2
    N-Boc-exo-3-aminotropane
    —— Cytidylyl-3',5'-adenosine phosphate 2382-66-3 C19H25N8O11P
    Cytidylyl-3',5'-adenosine phosphate
    —— 2-oxo-2-[(1S,2R)-1,2,10-trihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]ethyl acetate 86401-80-1 C23H30O7
    2-oxo-2-[(1S,2R)-1,2,10-trihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]ethyl acetate
    —— 1-(2-fluoro-4-iodophenyl)-3-(4-methoxybenzyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione 871700-54-8 C19H17FIN3O3
    1-(2-fluoro-4-iodophenyl)-3-(4-methoxybenzyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
    —— (3S,5S)-atorvastatin sodium 134523-01-6 C33H34FN2O5*Na
    (3S,5S)-atorvastatin sodium
    —— 2-Deoxy-2,2-difluoro-d-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate 134877-42-2 C20H18F2O8S
    2-Deoxy-2,2-difluoro-d-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
    —— JDQ443 2653994-08-0 C29H28ClN7O
    JDQ443
    —— (1-(4-bromophenyl)piperidin-4-yl)methanol 1296224-87-7 C12H16BrNO
    (1-(4-bromophenyl)piperidin-4-yl)methanol
    —— 7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 97224-58-3 C11H13N3O4
    7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
    —— 6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]adenosine 1025783-21-4 C41H40N6O8
    6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]adenosine
    —— (3R)-cyclopentyl-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinic acid salt 1236033-04-7 C18H14O8*C23H32N6OSi
    (3R)-cyclopentyl-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinic acid salt
    —— ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate 1335290-31-7 C11H9F2NO2
    ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate
    —— (4Z)-4-(1H-indol-3-ylmethylidene)-4H-imidazole-2,5-diol 5453-51-0 C12H9N3O2
    (4Z)-4-(1H-indol-3-ylmethylidene)-4H-imidazole-2,5-diol
    —— 1-Isopropyl-2-methoxy-4-methylcyclohexane 1565-76-0 C11H22O
    1-Isopropyl-2-methoxy-4-methylcyclohexane
    —— Sodium2-(3-((2-methyl-4-sulfonatophenyl)amino)-6-(o-tolylamino)xanthylium-9-yl)benzoate 6252-76-2 C34H25N2NaO6S
    Sodium2-(3-((2-methyl-4-sulfonatophenyl)amino)-6-(o-tolylamino)xanthylium-9-yl)benzoate
    —— Meso-(3aR,5s,6aS)-tert-butyl5-aminohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylatee 1221439-83-3 C12H22N2O2
    Meso-(3aR,5s,6aS)-tert-butyl5-aminohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylatee
    —— disodium GDP 7415-69-2 C10H15N5Na2O11P2+2
    disodium GDP
    —— (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid 1842397-36-7 C12H14BNO5
    (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid
    —— (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid 38030-57-8 C20H26O3
    (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    —— bis(2-methoxyethyl) azodicarboxylate 940868-64-4 C8H14N2O6
    bis(2-methoxyethyl) azodicarboxylate
    —— methyl-(4-trifluoromethyl-cyclohexyl)-amine hydrochloride salt 800386-46-3 C8H14F3N*ClH
    methyl-(4-trifluoromethyl-cyclohexyl)-amine hydrochloride salt
    —— 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate 875302-45-7 C46H63N4O9PSi
    5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate
    —— methyl (methyl 2,3,4-tri-O-acetyl-α-DL-talopyranosid)uronate 30902-96-6 C14H20O10
    methyl (methyl 2,3,4-tri-O-acetyl-α-DL-talopyranosid)uronate
    —— 3-hydroxyestra-1,3,5(10),15-tetraen-17-one 3563-25-5 C18H20O2
    3-hydroxyestra-1,3,5(10),15-tetraen-17-one