2-乙烯基-N,N-二甲基苄胺 | 22826-55-7

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙烯基-N,N-二甲基苄胺
• 中文别名: N-2-乙烯基苄基-N,N-二甲胺
• 英文名称: N,N-dimethylaminomethylstyrene
• 英文别名: 1-(2-ethenylphenyl)-N,N-dimethylmethanamine；2-(N,N-dimethylaminomethyl)styrene；ortho-(Dimethylaminomethyl)styrene；N,N-dimethyl-(2-vinylbenzyl)amine；2-Vinyl-N,N-dimethylbenzylamine；N,N-dimethyl-2-vinylbenzylamine；N,N-Dimethyl-1-(2-vinylphenyl)methanamine
• CAS: 22826-55-7
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: YVLKCQAGVDGTRH-UHFFFAOYSA-N

物化性质

• 沸点：
  212.9℃
• 密度：
  0.937
• 闪点：
  74.7℃

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-乙烯基-N,N-二甲基苄胺 在 臭氧 作用下， 生成 2-((dimethylamino)methyl)benzaldehyde
  参考文献：
  名称：

  霍夫曼降解引起的碳环形成

  摘要：

  DOI：

  10.1002/ardp.19542870922
• 作为产物：
  描述：

  2,2-dimethyl-1,2,3,4-tetrahydro-isoquinolinium, chloride 在 sodium amalgam 、 水 作用下， 生成 2-乙烯基-N,N-二甲基苄胺
  参考文献：
  名称：

  Emde, Justus Liebigs Annalen der Chemie, 1912, vol. 391, p. 93

  摘要：

  DOI：

文献信息

• Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors
  作者：Kirill B Polyanskii、Kseniia A Alekseeva、Pavel V Raspertov、Pavel A Kumandin、Eugeniya V Nikitina、Atash V Gurbanov、Fedor Ivanovich Zubkov

  DOI：10.3762/bjoc.15.73

  日期：——

  of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10−2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM).

  报道了一种新颖且有效的合成2-乙烯基苄胺的方法。这涉及通过烷基化和还原，然后进行霍夫曼裂解，从四氢异喹啉获得2-乙烯基苄胺配体。生成的2-乙烯基苄胺使我们能够获得新的Hoveyda-Grubbs催化剂，并通过NMR，ESIMS和X射线晶体学对其进行了全面表征。通过在不同复分解反应（如交叉复分解（CM），闭环复分解（RCM）和开环交叉复分解）中的新型催化剂（最高10 -2 mol％）的测试，进一步证明了该化学方法的实用性（ ROCM）。
• ENGINEERED CELLS AND AGENT COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20200276318A1

  公开（公告）日：2020-09-03

  Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

  本文提供了经过工程改造的细胞以及用于工程改造细胞以传递治疗剂的方法，例如小分子、肽或其他药物，以传递到待治疗的细胞或组织。
• CELL BASED METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20200405881A1

  公开（公告）日：2020-12-31

  Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

  本文提供了经过工程改造的细胞以及用于工程改造细胞以传递治疗剂的方法，例如小分子、肽或其他药物，以治疗细胞或组织。
• METHOD FOR PRODUCING MODIFIED CONJUGATED DIENE-BASED POLYMER, MODIFIED CONJUGATED DIENE-BASED POLYMER, POLYMER COMPOSITION, CROSSLINKED BODY, TIRE AND COMPOUND
  申请人：JSR CORPORATION

  公开号：US20190194430A1

  公开（公告）日：2019-06-27

  A modified conjugated diene-based polymer having high Mooney viscosity and good shape stability and exhibiting excellent processability and low heat build-up is obtained in as few steps as possible. The modified conjugated diene-based polymer is produced by a method of reacting a conjugated diene-based polymer having an active chain end, obtained by polymerizing a monomer containing a conjugated diene compound in the presence of an initiator that contains at least either of an alkali metal compound and an alkaline earth metal compound, with a compound [M] having at least two groups selected from the group consisting of a group “—C(R 1 )N-A 1 ” and a group “—N═C(R 1 )-A 1 ”, where R 1 is a hydrogen atom or a hydrocarbyl group and A 1 is a monovalent group having an alkoxysilyl group.

  通过尽可能少的步骤获得具有高莫尼粘度和良好形状稳定性、表现出优异加工性和低热积聚的改性共轭二烯基聚合物。这种改性共轭二烯基聚合物是通过一种方法制备的，该方法涉及将在至少含有碱金属化合物和碱土金属化合物中的至少一种的引发剂存在下聚合含有共轭二烯化合物的单体而获得具有活性链端的共轭二烯基聚合物与具有至少两个从群组“—C(R1)N-A1”和群组“—N═C(R1)-A1”中选择的基团的化合物[M]反应，其中R1是氢原子或烃基团，A1是具有烷氧基团的一价基团。
• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。