胸腺嘧啶-T | 28854-96-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 中文名称: 胸腺嘧啶-T
• 英文名称: 1-[(2R,4S,5R)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 28854-96-8
• 化学式: C10H14N2O5
• 分子量: 244.24
• InChiKey: IQFYYKKMVGJFEH-OFKYTIFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS FOR MEDICAL USE AS PEPTIDASE EFFECTORS
  申请人：ANSORGE Siegfried

  公开号：US20120028995A1

  公开（公告）日：2012-02-02

  The invention relates to compounds of general formula (I) as set forth in the claims as well as to the use of the compounds of the general formula (1) in the medical field, specifically for use in the suppression of DNA synthesis and inflammatory cytokine production as well as in the stimulation of anti-inflammatory cytokine production in vitro and in vivo. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

  该发明涉及一般式（I）所述的化合物，以及该一般式（1）化合物在医学领域中的使用，具体用于抑制DNA合成和炎症细胞因子的产生，以及在体外和体内刺激抗炎细胞因子的产生。本摘要既不旨在定义本说明书中披露的发明，也不旨在以任何方式限制发明的范围。
• [EN] NOVEL MULTIFUNCTIONAL PEPTIDASE INHIBITORS, ESPECIALLY FOR MEDICAL USE<br/>[FR] NOUVEAUX INHIBITEURS DE PEPTIDASE MULTIFONCTIONNELS, PARTICULIÈREMENT DESTINÉS À UN USAGE MÉDICAL
  申请人：IMTM GMBH

  公开号：WO2011026781A1

  公开（公告）日：2011-03-10

  The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.

  该发明涉及通式（1）的化合物或其与有机和/或无机酸形成的酸盐；以及通式（1）化合物在医药中的应用。
• Novel multifunctional peptidase inhibitors, especially for medical use
  申请人：IMTM GmbH

  公开号：EP2292589A1

  公开（公告）日：2011-03-09

  The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.

  该发明涉及通式（1）的化合物或其与有机和/或无机酸形成的酸盐；以及通式（1）化合物在医药中的应用。
• Fused bicyclic amide compounds and medicinal use thereof
  申请人：——

  公开号：US20030203909A1

  公开（公告）日：2003-10-30

  The present invention provides a compound represented by the formula (I) 1 wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R 1 , R 2 and R 3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由以下化学式（I）1所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环B为苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等，W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X′为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用，并可用作各种自身免疫性疾病的预防或治疗剂。
• THERAPEUTIC AGENT COMPRISING GLYCOLIPID DERIVATIVE CAPABLE OF INHIBITING THE FUNCTION OF NKT CELL AS ACTIVE INGREDIENT
  申请人：Japan as represented by President of National Center of Neurology and Psychiatry

  公开号：EP1952814A1

  公开（公告）日：2008-08-06

  A therapeutic drug for diseases, in which NKT cells or stimulus of NKT cells is involved in deterioration of disease conditions, containing, as an active ingredient, a glycolipid derivative having the formula (I): wherein R1 indicates an aldopyranose residue, R2 indicates a hydrogen atom or a hydroxy group, A indicates -CH2-, -CH(OH)-CH2- or -CH=CHCH2-, x indicates an integer of 13 to 16 and y indicates an integer of 0 to 25 or its pharmacologically acceptable hydrate or solvate.

  一种治疗疾病的药物，其中NKT细胞或NKT细胞的刺激参与了疾病状况的恶化，包含一种具有以下式（I）的糖脂衍生物作为活性成分：其中R1表示醛基吡喃糖残基，R2表示氢原子或羟基，A表示-CH2-，-CH（OH）-CH2-或-CH=CHCH2-，x表示13至16的整数，y表示0至25的整数，或其药理学上可接受的水合物或溶剂化合物。