申请人:——
公开号:US20030203909A1
公开(公告)日:2003-10-30
The present invention provides a compound represented by the formula (I)
1
wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R
1
, R
2
and R
3
are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
本发明提供了一种由以下
化学式(I)1所代表的化合物,其中环A为苯、
环己烷、
吡啶、
哌啶或其衍
生物、
咪唑或其衍
生物等,环B为苯、
环己烷、
吡咯或其衍
生物、
呋喃、
噻吩等,R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等,W为氢、烷基或羟基羰基烷基,X为卤素、
氰基、硝基等,X′为氢、卤素等,Y为烷基、羟基烷基、羟基羰基烷基、
氨基烷基等,其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用,并可用作各种自身免疫性疾病的预防或治疗剂。