The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
本发明涉及式I的化合物,其中A1、A2、R4和Q如本文所定义。本发明的化合物是热休克因子1(HSF1)的
抑制剂。具体来说,本发明涉及将这些化合物用作治疗和/或预防增殖性疾病,如癌症的治疗剂。本发明还涉及制备这些化合物的方法,以及包含它们的药物组合物。