麦角腈甲磺酸盐 | 51473-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 麦角腈甲磺酸盐
• 英文名称: Lergotrile mesylate
• 英文别名: 2-[(6aR,9S,10aR)-5-chloro-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]acetonitrile;methanesulfonic acid
• CAS: 51473-23-5
• 化学式: C18H22ClN3O3S
• 分子量: 395.9
• InChiKey: WXHDJVDIJQDJMK-AYJWUPBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• [EN] DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF<br/>[FR] LIQUIDES IONIQUES À DOUBLE FONCTION ET SELS DE CEUX-CI
  申请人：UNIV ALABAMA

  公开号：WO2010078300A1

  公开（公告）日：2010-07-08

  Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are 'solvated,' for example, 'hydrated' and their uses.

  本文揭示了包括活性药物、生物学和营养化合物的离子液体组合物，以及其使用方法。进一步揭示了包括液态离子对的物质组合物，单独或溶解后使用；以及离子液体的“溶剂化”组合物，例如“水合”的组合物及其用途。
• DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF
  申请人：Rogers Robin D.

  公开号：US20120046244A1

  公开（公告）日：2012-02-23

  Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are ‘solvated,’ for example, ‘hydrated’ and their uses.

  本文揭示了包括活性药物、生物和营养化合物的离子液体组成，以及使用方法。进一步揭示了液态离子对或其溶液的物质组成和使用方法；包括“溶剂化”的离子液体组成，例如“水化”的离子液体组成及其用途。
• Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients
  申请人：Rogers Robin D.

  公开号：US20120264605A1

  公开（公告）日：2012-10-18

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  本发明涉及离子液体和制备含有活性制药、生物、营养和能量成分的离子液体组合物的方法。同时，本发明还涉及使用所述组合物的方法，以克服多晶性、克服溶解度和输送问题、控制释放速率、增加功能、增强功效（协同作用）和改善使用和制造的便利性。
• A material and composition for reducing blood pressure
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP0005074A1

  公开（公告）日：1979-10-31

  A material and composition for reducing blood pressure are provided. The blood pressure in animals is reduced by administering lergotrile, viz. 2-chloro-6-methylergoline-8β-acetonitrile or pharmaceutically acceptable salts thereof either alone or in combination with a substance which is known to reduce blood pressure. A composition is provided comprising a unit dosage form of lergotrile and a substance which is known to reduce blood pressure. For lergotrile, any of its physiologically- and pharmacologically-active metabolites in the body can be substituted.

  提供了一种用于降低血压的材料和组合物。 通过单独或与已知可降低血压的物质结合使用麦角三腈，即 2-氯-6-甲基麦角林-8β-乙腈或其药学上可接受的盐，可降低动物的血压。 提供了一种组合物，其中包括单位剂型的麦角三腈和已知可降低血压的物质。 可以用麦角三腈在体内的任何具有生理和药理活性的代谢物来代替麦角三腈。