1,1,2,2-四氢全氟烷基碘化物(C4-C20) | 68188-12-5

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 中文名称: 1,1,2,2-四氢全氟烷基碘化物(C4-C20)
• 中文别名: C2-18-全氟烷基碘乙烷；全氟烷基乙基碘
• 英文名称: 1,1,1,2,2,3,3-heptafluoro-5-iodopentane
• CAS: 68188-12-5
• 化学式: C₅H₄F₇I
• mdl: MFCD00155834
• 分子量: 323.98
• InChiKey: TZNRRNKRZXHADL-UHFFFAOYSA-N

物化性质

• 沸点：
  130-270 °C
• 密度：
  1.8
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1,1,2,2-四氢全氟烷基碘化物(C4-C20) 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 N,N-二甲基乙酰胺 为溶剂， 反应 8.0h， 生成 [4,4'-bis(2-methylpropyl)[2,2'-bipyridine]-4,4'-dicarboxylate-κΝ¹,κΝ^1'][4-methyl-4'-(perfluoro-1H,1H,2H,2H,3H,3H-hexyl)-2,2'-bipyridine-κΝ¹,κΝ^1']bis(thiocyanato-κN)ruthenium
  参考文献：
  名称：

  [EN] NOVEL FLUORINATED METAL COMPLEXES
  [FR] NOUVEAUX COMPLEXES MÉTALLIQUES FLUORÉS

  摘要：

  基于双吡啶配体的新改进的氟化金属配合物已经公开。这些配合物的特点是在连接到吡啶环的特定取代基之间实现氟化平衡，即整体氟原子数量在这些取代基中的范围为7至26，并且同时，这些取代基之间的氟原子数量差异等于或小于13。这些新配合物有利地将良好的溶解性与极高的光伏性能结合在一起，特别是在极性溶剂，尤其是醇类溶剂中。

  公开号：

  WO2019029789A1
• 作为产物：
  描述：

  乙烯 、 七氟-1-碘丙烷 生成 1,1,2,2-四氢全氟烷基碘化物(C4-C20)
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6

文献信息

• [EN] NITRILE COMPOUND AND ITS USE IN PEST CONTROL<br/>[FR] COMPOSE NITRILE ET SON UTILISATION POUR LE CONTROLE DES INSECTES ET ANIMAUX NUISIBLES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2005063694A1

  公开（公告）日：2005-07-14

  The present invention provides a nitrile compound represented by the formula (I): wherein R represents C1-C4 fluoroalkyl, Q represents halogen, C1-C11 alkyl optionally substituted with halogen, C2-C6 alkenyl group optionally substituted with halogen, C2-C6 alkynyl optionally substituted with halogen, C3-C7 cycloalkyl optionally substituted with halogen or (C3-C7 cycloalkyl optionally substituted with halogen)C1-C4 alkyl, which has excellent control effect against pests.

  本发明提供了一种由式(I)表示的腈化合物：其中R代表C1-C4氟烷基，Q代表卤素，C1-C11烷基可选择地取代卤素，C2-C6烯基基团可选择地取代卤素，C2-C6炔基可选择地取代卤素，C3-C7环烷基可选择地取代卤素或(C3-C7环烷基可选择地取代卤素)C1-C4烷基，对害虫具有出色的控制效果。
• Rational creation of mutant enzyme showing remarkable enhancement of catalytic activity and enantioselectivity toward poor substrates
  作者：Tadashi Ema、Shusuke Kamata、Masahiro Takeda、Yasuko Nakano、Takashi Sakai

  DOI：10.1039/c001561j

  日期：——

  Catalytic activity and enantioselectivity of lipase toward poor substrates bearing bulky substituents on both sides have been dramatically improved by rational design; the E value for a poor substrate was increased from 5 (wild-type enzyme) to >200 (I287F/I290A double mutant) with an acceleration of the reaction rate.

  通过合理设计，脂肪酶对两侧具有大取代基的差质底物的催化活性和对映选择性得到了显著提高；差质底物的E值从5（野生型酶）提高到>200（I287F/I290A双突变体），反应速率也加快。
• Synthesis and characterization of light-fluorous NHC-ligands and their palladium complexes
  作者：Angel S.W. Lo、Ken S.M. Yiu、István T. Horváth

  DOI：10.1016/j.jorganchem.2020.121634

  日期：2021.1

  α-olefins, branched dialkyl iodides, alkyl triflates, alkyl imidazoles, and dialkyl imidazolium salts. The latter were used to prepare two light-fluorous N,N’-dialkyl-imidazole-2-ylidene diiodo palladium(II) complexes. The fluorous partition coefficients of the light-fluorous olefins, iodides, and triflates were measured in perfluoro(methylcyclohexane)/toluene biphasic system, which revealed that the shorter

  含有全氟正丙基，全氟正丁基和全氟叔丁氧基的轻氟马尾辫被用来合成轻氟α-烯烃，支链二烷基碘化物，烷基三氟甲磺酸酯，烷基咪唑和二烷基咪唑鎓盐。后者用于制备两种轻氟的N，N′-二烷基-咪唑-2-亚烷基二碘钯（II）配合物。在全氟（甲基环己烷）/甲苯两相体系中测量了轻氟烯烃，碘化物和三氟甲磺酸酯的氟分配系数，这表明，轻氟马尾辫较短且对环境更友好的全氟烷基链导致较低的氟分配系数，特别是随着亚甲基数目的增加。
• Fluorinated triazole-containing sphingosine analogues. Syntheses and<i>in vitro</i>evaluation as SPHK inhibitors
  作者：Margarita Escudero-Casao、Adrià Cardona、Raúl Beltrán-Debón、Yolanda Díaz、M. Isabel Matheu、Sergio Castillón

  DOI：10.1039/c8ob01867g

  日期：——

  Sphingosine analogues with a rigid triazole moiety in the aliphatic chain and systematic modifications in the polar head and different degrees of fluorination at the terminus of the alkylic chain were synthesized from a common alkynyl aziridine key synthon. This key synthon was obtained by enantioselective organocatalyzed aziridination and it was subsequently ring opened in a regioselective manner

  从常见的炔基氮丙啶关键合成子合成了在脂肪族链中具有刚性三唑部分，在极性头上的系统修饰以及在烷基链末端具有不同氟化度的鞘氨醇类似物。该关键的合成子通过对映选择性的有机催化的叠氮化而获得，随后在酸性介质中以区域选择性的方式开环。以直接的方式制备了多达16种鞘氨醇类似物。在体外所获得的产品作为SPHK1和SPHK2抑制剂的活性进行评估，显示相当的活性到DMS的。
• Observing the Migration of Hydrogen Species in Hybrid Perovskite Materials through D/H Isotope Exchange
  作者：Subha Sadhu、Thierry Buffeteau、Simon Sandrez、Lionel Hirsch、Dario M. Bassani

  DOI：10.1021/jacs.0c02597

  日期：2020.6.10

  migration of hydrogen species in perovskite materials cannot be directly tracked using imaging or mass spectrocopy techniques. Our results show that quantitative analysis of D / H exchange in PbCH3ND3I3 allows indirect monitoring of H migration by following the N-D vibration using polarization-modulated infrared reflexion-absorption spectroscopy. Kinetic analysis shows that the isotope exchange process

  与重元素不同，钙钛矿材料中氢物种的迁移无法使用成像或质谱技术直接追踪。我们的结果表明，PbCH3ND3I3 中 D/H 交换的定量分析允许通过使用偏振调制红外反射吸收光谱跟踪 ND 振动来间接监测 H 迁移。动力学分析表明，同位素交换过程是准一级的，并且对光强度和相对湿度特别敏感，并且在较小程度上对样品厚度敏感。在有光 (450 nm) 的情况下，D / H 交换相对于黑暗中的样品加速了 10 倍，但在更高的光强度下再次减慢。这种意想不到的行为与电离增强离子迁移的 Bourgoin-Corbett 机制一致。该技术还允许直接评估保护层对湿气对混合有机 - 无机钙钛矿器件的劣化的效率。不同单层形成氟化分子的比较揭示了速率的重要差异，证明了它们阻止水分子进入活性层的效率之间的差异。