3,3,4,4,5,5,5-七氟戊酸 | 679-46-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3,3,4,4,5,5,5-七氟戊酸
• 英文名称: 3,3,4,4,5,5,5-heptafluoropentanoic acid
• 英文别名: 2H,2H-heptafluoro-valeric acid；2H,2H-Heptafluor-valeriansaeure；2H,2H-Heptafluor-valeriansaeure
• CAS: 679-46-9
• 化学式: C₅H₃F₇O₂
• 分子量: 228.066
• InChiKey: NLAGAXIWWHZGCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3,3,4,4,5,5,5-七氟戊酸 在 氯化亚砜 作用下， 生成 2H,2H-heptafluoro-valeryl chloride
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6
• 作为产物：
  描述：

  甲基-(2,2,3,3,3-五氟-丙基)-胺 在 chromium(VI) oxide 、 氢氧化钾 、 硫酸 、 丙酮 、 二乙二醇 作用下， 生成 3,3,4,4,5,5,5-七氟戊酸
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6

文献信息

• Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides
  作者：Lennart Brewitz、Fernando Arteaga Arteaga、Liang Yin、Kaliyamoorthy Alagiri、Naoya Kumagai、Masakatsu Shibasaki

  DOI：10.1021/jacs.5b11064

  日期：2015.12.23

  emergence of direct enolization protocols providing atom-economical and operationally simple methods to use enolates for stereoselective C-C bond-forming reactions, eliminating the inherent drawback of the preformation of enolates using stoichiometric amounts of reagents. In its infancy, direct enolization relied heavily on the intrinsic acidity of the latent enolates, and the reaction scope was limited

  过去二十年见证了直接烯醇化方案的出现，提供了原子经济且操作简单的方法来使用烯醇化物进行立体选择性 CC 键形成反应，消除了使用化学计量量的试剂预先形成烯醇化物的固有缺点。在其初期，直接烯醇化严重依赖潜在烯醇化物的固有酸性，反应范围仅限于易于烯醇化的酮和醛。该领域的最新进展使开发羧酸衍生物直接烯醇化成为可能，从而提供了合成通用手性构件的快速途径。尽管对富含对映体的含氟小分子的需求不断增长，由于竞争性和主导性的脱氟途径，α-和β-氟化羰基化合物在直接烯醇化化学中被忽略。在此，我们对 α- 和 β-氟官能化 7-氮杂吲哚啉酰胺的直接和高度立体选择性曼尼希型反应进行了全面研究，该反应依赖于软路易斯酸/硬布朗斯台德碱协同催化体系来保证有效的烯醇化，同时抑制不需要的脱氟。该协议有助于为药物化学提供一系列富含对映体的 β-氨基酸的氟化类似物。在此，我们对 α- 和 β-氟官能化 7-氮杂吲哚啉酰胺的直接
• Novel Elimination Reactions of Telomer Iodides of 1,1-Difluoroethylene¹
  作者：Murray Hauptschein、Robert E. Oesterling

  DOI：10.1021/ja01496a049

  日期：1960.6
• FLUORINATED ZWITTERIONIC POLYMERS AND METHODS OF USE
  申请人：[en]CORNELL UNIVERSITY

  公开号：WO2023249926A2

  公开（公告）日：2023-12-28

  Fluorinated monomer compositions having the formula: A-L-Z (1), wherein A is a polymerizable group (e.g., a vinyl group); L is a bond or linking portion; Z is a zwitterionic moiety or a zwitterionic precursor moiety containing a protecting group capable of deprotection to form a charged group; wherein at least one hydrogen atom in A, L, and/or Z in Formula (1) is substituted by a fluorinated hydrocarbon group, wherein the fluorinated hydrocarbon group contains 1-12 carbon atoms and precisely or at least one, two, three, four, five, or six fluorine atoms. Also described herein are fluorinated zwitterionic polymers derived from such monomers. Also described herein are mixed-charge zwitterionic polymers. Other aspects include methods for producing the monomers and polymers, bulk material (e.g., hydrogel or copolymer hybrid) compositions of any of the zwitterionic polymers described herein, fouling-resistant and/or fouling releasing surfaces and objects, and nanoparticles containing the polymer or bulk material.