Ubiquinol,Dihydrocoenzyme Q10 | 992-78-9

• 物质功能分类: 食品添加剂 - 抗氧化剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Ubiquinol,Dihydrocoenzyme Q10
• 英文别名: 2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl)-5,6-dimethoxy-3-methylbenzene-1,4-diol
• CAS: 992-78-9；75426-26-5
• 化学式: C₅₉H₉₂O₄
• 分子量: 865.377
• InChiKey: QNTNKSLOFHEFPK-BJFJAEGNSA-N

物化性质

• 熔点：
  48-49°C
• 沸点：
  866.9±65.0 °C(Predicted)
• 密度：
  0.951±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿：可溶

计算性质

• 辛醇/水分配系数(LogP)：
  18.47
• 重原子数：
  63.0
• 可旋转键数：
  31.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Ubiquinol (Ubiquinol-10) 是辅酶 Q10 (CoQ10) 的还原形式。Ubiquinol 是一种有效的抗氧化剂，具有保护维生素 E 的能力，还保护难以再生的维生素 E 和维生素 C。Ubiquinol 既具有亲脂性又具有亲水性，并作为跨膜因子，通过将电子转移至 ROS 来防止脂质过氧化和扩散。

体外研究

The lipophilic environment encircles the lipophilic low-molecular-weight antioxidants (α-tocopherol, β-carotene, and Ubiquinol) and prevents them from reacting as skin protectors.
Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former and has been suggested to be a relevant factor in aging as well as in different pathological conditions, such as heart attack, diabetes, and cancer. Ubiquinol is very sensitive against oxygen radicals and gives ubiquinone as an oxidation product. Therefore, the ratio of ubiquinol to ubiquinone should be a good marker of oxidative stress because of its definition.

体内研究

The oxidized (UQox) and reduced (Ubiquinol) forms of ubiquinone (UQ) homologues in rat tissues and subcellular fractionsare analyzed. The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular fractions isolated from liver and kidney in about the same ratio as Ubiquinol/t-UQ is present in the whole organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes.