医药中间体是指在药物合成过程中作为关键步骤的反应产物或原料物质,它们通常是化学结构较为简单的化合物,通过一系列化学反应可以转化为最终的药物成品。这些中间体在制药工业中扮演着重要角色,是实现复杂药物分子合成的关键组成部分。
特点医药中间体的研发和生产是一个复杂的过程,通常包括以下几个步骤:
随着化学合成技术的进步和新技术的应用(如绿色化学、计算机辅助设计等),医药中间体的研发与生产正朝着更加高效、环保的方向发展。同时,对药物分子结构的深入理解也为开发更有效的治疗方案提供了更多可能性。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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N-[芴甲氧羰基]-4-[[[(4S)-六氢-2,6-二氧代-4-嘧啶基]羰基]氨基]-L-苯丙氨酸 | Fmoc-Aph(Hor)-OH | 1253282-31-3 | C29H26N4O7 |
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N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-n-(2-吡啶)-beta-丙氨酸乙酯盐酸盐 | ethyl 3-(2((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride | 211914-50-0 | C27H29N7O3*ClH |
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N-[[2-(氯甲基)-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-beta-丙氨酸乙酯 | N-[[2-(chloromethyl)-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridyl-β-alanine ethyl ester | 1307233-94-8 | C20H21ClN4O3 |
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N-[5-[(4-甲基苯基)磺酰基]-5H-吡咯并[2,3-B]吡嗪-2-基]氨基甲酸乙酯 | ethyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate | 1869118-24-0 | C16H16N4O4S |
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N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺 | N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)- 6-isopropylpyrimidin-2-yl)-N-methylmethansulfonamide | 289042-10-0 | C28H29FN3O3PS |
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N-[5-(三氟甲基)-2-吡啶基]-N-甲基肼 | N-methyl-N-(5-trifluoromethyl-pyridin-2-yl)-hydrazine | 163620-24-4 | C7H8F3N3 |
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N-[5-(4-溴苯基)-6-氯-4-嘧啶基]-N'-丙基氨基磺酰胺 | N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N'-propylsulfamide | 1393813-42-7 | C13H14BrClN4O2S |
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N-[4-溴-2-(2-吡啶甲酰基)苯基]-2-氯乙酰胺 | N-(4-bromo-2-picolinoylphenyl)-2-chloroacetamide | 41526-21-0 | C14H10BrClN2O2 |
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N-[4-三氟甲基嘧啶-2-基]乙二胺 | tert-butyl furan-2-ylcarbamate | 56267-47-1 | C9H13NO3 |
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N-[4-[(2-氨基-3-氯吡啶-4-基)氧基]-3-氟苯基]-4-乙氧基-1-(4-氟苯基)-2-氧代-1,2-二氢吡啶-3-甲酰胺 | BMS-777607 | 1025720-94-8 | C25H19ClF2N4O4 |
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N-[4-(氨基磺酰基)苄基]乙酰胺 | N-(4-sulfamoylbenzyl)acetamide | 2015-14-7 | C9H12N2O3S |
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N-[4-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)苯基]甘氨酸 | 2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid | 872728-82-0 | C10H9N3O4 |
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N-[3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶基]甲基兰索拉唑硫醚 | 1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole | 1083100-27-9 | C25H22F6N4O2S |
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N-[3-氟-4-[6-(2-甲基-2H-四唑-5-基)-3-吡啶基]苯基]氨基甲酸苄酯 | 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester | 1220910-89-3 | C21H17FN6O2 |
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N-[3-氟-4-[(甲基氨基)羰基]苯基]-2-甲基丙氨酸 | 2-(3-fluoro-4-methylcarbamoyl-phenylamino)-2-methyl-propionic acid | 1289942-66-0 | C12H15FN2O3 |
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N-[3-氟-4-[(甲基氨基)羰基]苯基]-2-甲基-丙氨酸甲酯 | N-[3-fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine methyl ester | 1332524-01-2 | C13H17FN2O3 |
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N-[3-[[3-环丙基-1-(2-氟-4-碘苯基)-1,2,3,4,7,8-六氢-6,8-二甲基-2,4,7-三氧代吡啶并[2,3-d]嘧啶-5-基]氨基]苯基]乙酰胺 | N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide | 871700-25-3 | C26H23FIN5O4 |
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N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺 | N-[3-([2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo(4,5-c)pyridin-6-yl]oxy)phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide | 850664-21-0 | C29H30N8O5 |
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N-[3-[5-(4-氯苯基)-1-(2,6-二氯苯甲酰基)-1H-吡咯并[2,3-b]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙烷磺酰胺 | propane-1-sulfonic acid {3-[5-(4-chlorophenyl) 1-(2,6-dichloro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide | 1262985-23-8 | C30H20Cl3F2N3O4S |
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N-[3-[(5-溴-1H-吡咯并[2,3-b]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙烷磺酰胺 | N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide | 918504-27-5 | C17H14BrF2N3O3S |
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N-[3-(9H-咔唑-9-基)-2-羟丙基]-N-(2-呋喃基甲基)甲磺酰胺 | N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | 309928-48-1 | C21H22N2O4S |
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N-[3-(4-苄基苯氧基)丙基]-N-甲基-beta-丙氨酸 | SC-57461A | 423169-68-0 | C20H25NO3*ClH |
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N-[3,5-双(三氟甲基)苯基]-N'-[(8a,9S)-6'-甲氧基-9-金鸡宁]硫脲 | 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea | 852913-16-7 | C29H28F6N4OS |
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N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-b]噻唑-6-基]苯基]-2-喹喔啉甲酰胺 | SRT1720 | 925434-55-5 | C25H23N7OS |
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N-[2-[(4-羟基苯基)氨基]-3-吡啶基]-4-甲氧基苯磺酰胺 | N-((2Z)-2-((4-hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide 2 | 141430-65-1 | C18H17N3O4S |
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N-[2-(吡啶-2-羰基)苯基]苯甲酰胺 | benzoic acid-[2-(pyridine-2-carbonyl)-anilide] | 91025-05-7 | C19H14N2O2 |
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N-[2-(二乙基氨基)乙基]-2-甲氧基-4-乙酰氨基-5-氯苯甲酰胺 | N-acetylmetoclopramide | 5608-13-9 | C16H24ClN3O3 |
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N-[2-(乙酰基氧基)丙基]-n-[3-[4-(1,1-二甲基丙基)苯基]-2-甲基丙基]-甲酰胺 | 1-(Formyl{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}amino)propan-2-yl acetate | 142347-84-0 | C21H33NO3 |
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N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺 | serdemetan | 881202-45-5 | C21H20N4 |
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N-[2-(1-哌嗪基)乙基]-1,2-乙二胺 | 1-<2-(2-aminoethyl)aminoethyl>piperazine | 24028-46-4 | C8H20N4 |
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N-[1,1’-联苯]-2-基-9,9-二甲基-9H-芴-2-胺 | N-([1,1'-biphenyl]-2-yl)-9,9-dimethyl-9H-fluoren-2-amine | 1198395-24-2 | C27H23N |
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N-[1,1`-联苯胺]-4-基-1-萘胺 | N-([1,1'-biphenyl]-4-yl)naphthalen-1-amine | 446242-37-1 | C22H17N |
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N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺 | N-([1,1'-biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-amine | 897671-69-1 | C27H23N |
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N-[(S)-(2,3,4,5,6-五氟苯氧基)苯氧基磷酰基]-L-丙氨酸异丙酯 | isopropyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate | 1334513-02-8 | C18H17F5NO5P |
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N-[(R)-[(1,2-二氢-1-甲基磺酰螺[3H-INDOOLE-3,4'-哌啶]-1'-基)羰基]-2-(苯基甲氧基)乙基]-2-[(1,1-二甲基乙氧基)羰基]氨基-2-甲基-丙酰胺 | N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide | 159634-87-4 | C32H44N4O7S |
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N-[(9H-芴-9-甲氧基)羰基]-L-苏氨酸苯基甲酯 | N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester | 73724-48-8 | C26H25NO5 |
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N-[(9H-芴-9-基甲氧基)羰基]-3-[(苯基甲基)硫代]-D-缬氨酸 | Fmoc-S-benzyl-D-penicillamine | 139551-73-8 | C27H27NO4S |
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N-[(5-甲基-3-吡啶基)甲基]-4-氯哌啶 | 3-((4-Chloropiperidin-1-yl)methyl)-5-methylpyridine | 239136-47-1 | C12H17ClN2 |
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N-[(4S,6S)-5,6-二氢-6-甲基-4H-噻吩并[2,3-b]噻喃-4-基]乙酰胺-7,7-二氧化物 | N-(5,6-dihydro-(S)-6-methyl-4H-thieno<2,3-b>thiopyran-(S)-4-yl)acetamide 7,7-dioxide | 147086-83-7 | C10H13NO3S2 |
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N-[(4-硝基苯基)-甲基磺酰基]吡咯烷 | 1-(4-nitrophenylmethylsulfonyl)pyrrolidine | 340041-91-0 | C11H14N2O4S |
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N-[(3aS,4R,6S,6aR)-四氢-6-羟基-2,2-二甲基-4H-环戊烯并-1,3-二氧戊环-4-基]氨基甲酸苄酯 | benzyl ((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamate | 274693-53-7 | C16H21NO5 |
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N-[(3R,6S)-6-(2,3-二氟苯基)六氢-2-氧代-1-(2,2,2-三氟乙基)-1H-氮杂卓-3-基]-4-(2,3-二氢-2-氧代-1H-咪唑并[4,5-b]吡啶-1-基)-1-哌啶甲酰胺 | telcagepant | 781649-09-0 | C26H27F5N6O3 |
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N-[(2S)-4-甲基-1-[(2R)-2-甲基环氧乙烷-2-基]-1-氧代-2-戊基]氨基甲酸叔丁酯 | tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate | 247068-82-2 | C14H25NO4 |
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N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺 | pimasertib | 1204531-26-9 | C15H15FIN3O3 |
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N-[(2R,3S)-2-(2,5-二氟苯基)四氢-5-氧代-2H-吡喃-3-基]氨基甲酸叔丁酯 | tert-butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate | 951127-25-6 | C16H19F2NO4 |
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N-[(2R,3S)-2-(2,5-二氟苯基)-3,4-二氢-2H-吡喃-3-基]氨基甲酸叔丁酯 | tert-butyl ((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate | 1172623-98-1 | C16H19F2NO3 |
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N-[(1r,2s)-1-[[(环丙基磺酰基)氨基]羰基]-2-乙烯环丙基]氨基甲酸1,1-二甲基乙酯 | tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate | 630421-48-6 | C14H22N2O5S |
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N-[(1S,2S)-3-(4-氯苯基)-2-(3-氰基苯基)-1-甲基丙基]-2-甲基-2-[(5-(三氟甲基)吡啶-2-基)氧基]丙酰胺 | taranabant | 701977-09-5 | C27H25ClF3N3O2 |
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N-[(1S,2S)-2-氨基环丁基]氨基甲酸叔丁酯 | tert-butyl N-[(1S,2S)-2-aminocyclobutyl]carbamate | 1374222-18-0 | C9H18N2O2 |
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N-[(1R,3R)-3-羟基环戊基]氨基甲酸叔丁酯 | tert-butyl [(1R,3R)-3-hydroxycyclopentyl]carbamate | 1290191-64-8 | C10H19NO3 |
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