14-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的类似物,能够抑制 NF-κB 活化。
靶点NF-κB
体外研究14-Deoxy-11,12-didehydroandrographolide(一种天然非细胞毒性的 Andrographolide 类似物),能有效减少卵清蛋白 (OVA) 引起的气道灌洗液中炎症细胞募集、IL-4、IL-5、IL-13 和 eotaxin 的产生,降低血清 IgE 合成、肺部嗜酸性粒细胞性浸润、黏液过度分泌、肥大细胞脱颗粒以及气道高反应性 (AHR),这可能通过抑制 NF-κB 活性实现。
体内研究14-Deoxy-11,12-didehydroandrographolide(剂量为 1 mg/kg)显著降低 OVA 刺激小鼠对乙酰甲胆碱的阻力 (Rl) 并恢复 Cdyn。
中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
穿心莲内酯 | andrographolide | 5508-58-7 | C20H30O5 | 350.455 |
—— | andrographolide | —— | C20H30O5 | 350.455 |
—— | andrographolide | —— | C20H30O5 | 350.455 |
—— | 3,18-O-isopropylideneandrographolide | 372939-35-0 | C23H34O5 | 390.52 |
中文名称 | 英文名称 | CAS号 | 化学式 | 分子量 |
---|---|---|---|---|
—— | ((1R,2R,4aR,8aS)-2-hydroxy-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)vinyl)decahydronaphthalen-1-yl)methyl acetate | 1207722-88-0 | C22H30O5 | 374.477 |
—— | 14-deoxy-11,12-didehydroandrographolide-19-al | —— | C20H26O4 | 330.424 |
—— | 3,19-diacetyl-14-deoxy-11,12-didehydroandrographolide | 42895-60-3 | C24H32O6 | 416.514 |
—— | 9β-hydroxydehydroandrographolide | 1161442-54-1 | C20H28O5 | 348.439 |
—— | 3-oxo-14-deoxy-11,12-didehydroandrographolide | 919120-75-5 | C20H26O4 | 330.424 |
—— | 14-deoxy-15-isopropylidene-11,12-didehydroandrographolide | —— | C23H32O4 | 372.505 |
—— | 14-deoxy-11,14-didehydroandrographolide-3,19-di-O-cyclophosphate | —— | C20H27O6P | 394.405 |
—— | 3,19-dioxolabda-8(17),11E,13-trien-16,15-olide | 1032910-85-2 | C20H24O4 | 328.408 |
—— | 3-[(E)-2-((4aR,4bS,8R,8aR,10aR)-2-Chloro-4a,8a-dimethyl-7-methylene-2-oxo-decahydro-1,3-dioxa-2λ5-phospha-phenanthren-8-yl)-vinyl]-5H-furan-2-one | 824933-95-1 | C20H26ClO5P | 412.85 |
—— | 3-((E)-2-((1S,2S,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyloctahydro-1H-spiro[naphthalene-2,2′-oxiran]-1-yl)vinyl)furan-2(5H)-one | 887906-73-2 | C20H28O5 | 348.439 |
—— | 14-deoxy-11,12-didehydro-8,17-epoxyandrographolide | 1198787-87-9 | C20H28O5 | 348.439 |
—— | 3-oxo-19-O-[2-(4-hydroxypiperidino)acetyl]dehydroandrographolide | 1575716-91-4 | C27H37NO6 | 471.594 |
—— | 14-deoxy-11,12-didehydro-3,19-dinicotinoylandrographolide | 943430-82-8 | C32H34N2O6 | 542.632 |
—— | 14-deoxy-12R-hydroxyandrographolide | 219721-30-9 | C20H30O5 | 350.455 |
—— | (1S,2R,4aS,5R,8aS)-1-formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl 2-aminoacetate | —— | C22H30N2O5 | 402.491 |
—— | 15-(benzo[1,3]dioxole-5-methanylidene)-14-deoxy-11,12-didehydroandrographolide | —— | C28H32O6 | 464.558 |