4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide | 36707-00-3

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
• CAS: 36707-00-3
• 化学式: C₁₃H₁₅N₅O₆
• 分子量: 337.29
• InChiKey: SPBWHPXCWJLQRU-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：微溶；二甲基亚砜：2mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  185
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• [EN] NOVEL SYNTHESIS OF LD101<br/>[FR] NOUVELLE SYNTHÈSE DE LD101
  申请人：LYNDOR BIOSCIENCES L L C

  公开号：WO2014074883A1

  公开（公告）日：2014-05-15

  Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.

  本发明揭示了制备按照公式（A）的化合物LD101的新型合成方法。
• Methods of detecting and treating a tumor expressing pT346 PDK1
  申请人：The Wistar Institute of Anatomy and Biology

  公开号：US11208478B2

  公开（公告）日：2021-12-28

  Therapeutic treatments of a tumor expressing pT346 PDK1, including glioma expressing pT346 PDK1, are disclosed.

  公开了表达 pT346 PDK1 的肿瘤（包括表达 pT346 PDK1 的胶质瘤）的治疗方法。
• INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY
  申请人：Cheng Jin Q.

  公开号：US20090028855A1

  公开（公告）日：2009-01-29

  The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.
• Methods of Detecting and Treating a Tumor Expressing PT346 PDK1
  申请人：The Wistar Institute of Anatomy and Biology

  公开号：US20190177411A1

  公开（公告）日：2019-06-13

  Therapeutic treatments of a tumor expressing pT346 PDK1, including glioma expressing pT346 PDK1, are disclosed.
• US8183249B2
  申请人：——

  公开号：US8183249B2

  公开（公告）日：2012-05-22