山栀苷; 山栀甙 | 29836-27-9

• 物质功能分类: 天然产物 - 环烯醚萜衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 山栀苷; 山栀甙
• 中文别名: 山栀苷；山栀苷;山栀甙
• 英文名称: shanzhiside
• 英文别名: (1S,4aS,5R,7S,7aS)-5,7-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid
• CAS: 29836-27-9
• 化学式: C₁₆H₂₄O₁₁
• 分子量: 392.36
• InChiKey: YSIFYNVXJOGADM-KDYWOABDSA-N

物化性质

• 沸点：
  692.3±55.0 °C(Predicted)
• 密度：
  1.69±0.1 g/cm3(Predicted)
• 溶解度：
  溶于甲醇和吡啶

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Shanzhiside 是一种环烯醚萜苷类化合物，是从福禄美属植物中分离获得的。它主要应用于含量测定、鉴定以及药理实验等方面。

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 山栀苷; 山栀甙 在 吡啶 作用下， 生成 hexaacetylshanzhiside
  参考文献：
  名称：

  Nicoletti, Marcello; Chapya, Wycliffe Andrew; Messana, Irene, Gazzetta Chimica Italiana, 1984, vol. 114, # 1/2, p. 49 - 54

  摘要：

  DOI：
• 作为产物：
  描述：

  tarennine 在 potassium carbonate 作用下， 生成 山栀苷; 山栀甙
  参考文献：
  名称：

  Nicoletti, Marcello; Chapya, Wycliffe Andrew; Messana, Irene, Gazzetta Chimica Italiana, 1984, vol. 114, # 1/2, p. 49 - 54

  摘要：

  DOI：

文献信息

• Sweet and bitter glycosides of the Chinese plant drug, Bai-Yun-Shen (roots of Salvia digitaloides).
  作者：Takashi Tanaka、Osamu Tanaka、ZhongWen Lin、Jun Zhou、Hiroyuki Ageta

  DOI：10.1248/cpb.31.780

  日期：——

  From a Chinese plant drug, Bai-Yun-Shen (roots of Salvia digitaloides), a new sweet glycoside named baiyunoside (1) was isolated. The structure of the acid-unstable aglycone of 1 named baiyunol (2) was elucidated by MS and NMR spectroscopy especially by comparison with the 13C chemical shifts of β-onocerin (3). The structure of 1 was determined to be β-D-xylopyranosyl (1→2)-β-D-glucopyranoside of 2 by MS and NMR spectroscopy. Besides this sweet principle (1), several bitter iridoid glucosides were also isolated from this plant. Two of these glucosides were identified as shanzhiside methyl ester (13) and its 8-O-acetate (=acetylbarlerin, 10), respectively. A new glucoside (9) was formulated as 6-O-syringyl-8-O-acetyl shanzhiside methyl ester by the correlation with 13.

  从中国植物药白云参（洋地黄鼠尾草的根）中分离出一种新的甜味苷，命名为白云苷（1）。通过 MS 和 NMR 光谱，特别是通过与 β-onocerin (3) 的 13C 化学位移进行比较，阐明了 1 的酸不稳定糖苷配基 baiyunol (2) 的结构。通过MS和NMR光谱确定1的结构为2的β-D-吡喃木糖基(1→2)-β-D-吡喃葡萄糖苷。除了这种甜味成分 (1) 之外，还从这种植物中分离出了几种苦味环烯醚萜苷。其中两种糖苷分别被鉴定为山栀苷甲酯 (13) 及其 8-O-乙酸酯 (=乙酰基巴勒林, 10)。通过与13的关联，将新的葡萄糖苷(9)定为6-O-紫丁香基-8-O-乙酰山枝苷甲酯。
• AN ESTERASE THAT IS CAPABLE OF CONVERTING IRIDOIDS AND SECO-IRIDOIDS
  申请人：N-Zyme BioTec GmbH

  公开号：EP3409766A1

  公开（公告）日：2018-12-05

  The present invention relates to a polypeptide having esterase activity selected from the group consisting of (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 7; (b) a polypeptide that is at least 60 % identical to the amino acid sequence of SEQ ID NO: 7 and which is characterized by having an esterase activity; (c) a polypeptide encoded by a nucleic acid molecule which is at least 60 % identical to the nucleic acid sequence of SEQ ID NO: 5 or 6 wherein said polypeptide is characterized by having an esterase activity; (d) a polypeptide encoded by the nucleic acid molecule of SEQ ID NO: 5 or 6; and (e) a polypeptide encoded by the complementary sequence of a nucleic acid molecule that is able to hybridize with the nucleic acid molecule of SEQ ID NO: 5 or 6. Further, the present invention relates to a polypeptide having esterase activity selected from the group consisting of SEQ ID NO: 24 and 37 (as encoded by nuleic acid molecule of SEQ ID NO: 22 or 23 and SEQ ID NO: 35 and 36). The present invention also relates to a method for the production of oleacein, oleocanthal, or decarboxymethyl elenolic acid dialdehyde (DEDA) comprising the use of the esterase of the present invention. to an organism, preferably a plant cell, genetically engineered with a nucleic acid molecule encoding a polypeptide characterized by having an esterase activity or the vector of the present invention. The present invention also relates to a method for the production of oleacein, oleocanthal, and/or decarboxymethyl elenolic acid dialdehyde (DEDA) comprising the use of the esterase of the present invention.

  本发明涉及一种具有酯酶活性的多肽，该多肽选自由以下组成的组 (a) 包含 SEQ ID NO: 7 的氨基酸序列的多肽；(b) 与 SEQ ID NO: 7 的氨基酸序列至少 60% 相同的多肽，其特征在于具有酯酶活性；(c) 由核酸分子编码的多肽，该核酸分子与 SEQ ID NO: 5 或 6 的核酸序列至少 60% 相同，其中所述多肽的特征在于具有酯酶活性；(d) 由 SEQ ID NO: 5 或 6 的核酸分子编码的多肽；以及(e) 由 SEQ ID NO: 6 的核酸分子编码的多肽：5或6的核酸分子编码的多肽，其中所述多肽的特征在于具有酯酶活性；(d)由SEQ ID NO：5或6的核酸分子编码的多肽；以及(e)由能够与SEQ ID NO：5或6的核酸分子杂交的核酸分子的互补序列编码的多肽。此外，本发明涉及一种具有酯酶活性的多肽，该多肽选自 SEQ ID NO: 24 和 37（由 SEQ ID NO: 22 或 23 和 SEQ ID NO: 35 和 36 的核酸分子编码）组成的组。本发明还涉及一种生产油菜素、油菜醛或脱羧甲基烯醇酸二醛（DEDA）的方法，包括使用本发明的酯酶。本发明涉及一种生物体，最好是植物细胞，其基因工程中含有编码具有酯酶活性的多肽的核酸分子或本发明的载体。本发明还涉及一种生产油菜素、油菜醛和/或脱羧甲基烯醇酸二醛（DEDA）的方法，包括使用本发明的酯酶。
• Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with pathogenic microbes
  申请人：DermBiont, Inc.

  公开号：US11040077B2

  公开（公告）日：2021-06-22

  Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.

  本文公开了使用源自人类的 Lividum Janthinobacterium 的组合物和方法。组合物可改善皮肤健康。方法可包括在宿主或宿主区域（如皮肤或粘膜）上施用源于人的生发的Lividum Janthinobacterium，以最大限度地减少一种或多种微生物的存在，最大限度地提高治疗效果，和/或改善健康状况。减少病原微生物的方法可包括向表面施用一种组合物，该组合物包括来源于人类的Janthinobacterium lividum和一种可接受的载体。组合物和方法可包括益生元，以最大限度地提高生长和/或代谢物。组合物和方法可包括来源于人的猪蓝细菌代谢物，如violacein、prodigiosin、吲哚-3-甲醛、兰特益生菌和/或其他后益生菌。
• Gardenia extract for dyeing keratin fibres
  申请人：PIERRE FABRE DERMO-COSMETIQUE

  公开号：US11266593B2

  公开（公告）日：2022-03-08

  The present invention relates to the use of a cosmetic composition intended for dyeing keratin fibres, especially human hair, said cosmetic composition comprising as active principle a Gardenia extract.

  本发明涉及一种用于角蛋白纤维（尤其是人类头发）染色的化妆品组合物，所述化妆品组合物的活性成分为栀子提取物。
• STABLE NATURAL COLOR PROCESS, PRODUCTS AND USE THEREOF
  申请人：Wild Flavors, Inc.

  公开号：EP2265134A1

  公开（公告）日：2010-12-29