N-茴香酰胺 | 7472-54-0
中文名称
N-茴香酰胺
中文别名
N-(4-甲氧苯基)苯甲酰胺；对苯茴香胺；4'-甲氧基苯酰替苯胺；N-苯甲酰对茴香胺
英文名称
N-(p-methoxyphenyl)benzamide
英文别名
N-(4-methoxyphenyl)benzamide；4'-methoxybenzanilide；p-benzanisidide
CAS
7472-54-0
化学式
C14H13NO2
mdl
MFCD00025788
分子量
227.263
InChiKey
KEEBHMMBUBEEOV-UHFFFAOYSA-N
BEILSTEIN
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EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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熔点：155°C
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沸点：290.2±23.0 °C(Predicted)
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密度：1.31 g/cm3
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稳定性/保质期：
如果按照规格使用和储存，则不会分解。
计算性质
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辛醇/水分配系数(LogP)：2.6
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重原子数：17
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可旋转键数：3
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环数：2.0
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sp3杂化的碳原子比例：0.071
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拓扑面积：38.3
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氢给体数：1
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氢受体数：2
安全信息
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安全说明：S22,S24/25
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海关编码：2924299090
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危险性防范说明：P261,P305+P351+P338
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危险性描述：H302,H315,H319,H335
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储存条件：密封在阴凉干燥环境中。
SDS
p-Benzanisidide Revision number: 1
SAFETY DATA SHEET
Section 1. BASE INFORMATION
Product name: p-Benzanisidide
Revision number: 1
Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS Not classified
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements
None
Pictograms or hazard symbols
Signal word No signal word
None
Hazard statement
Precautionary statements None
Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): p-Benzanisidide
Percent: >98.0%(GC)(T)
CAS Number: 7472-54-0
Synonyms: N-Benzoyl-p-anisidine , 4'-Methoxybenzanilide , N-(4-Methoxyphenyl)benzamide
Chemical Formula: C14H13NO2
Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.
Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
p-Benzanisidide
Section 5. FIRE-FIGHTING MEASURES
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:
Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.
Section 7. HANDLING AND STORAGE
Handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.
Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.
Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Form: crystal - powder
Color: White - Pale yellow red
Odor: No data available
pH: No data available
Melting point/freezing point:155 °C
Boiling Point/Range: No data available
Flash Point: No data available
Explosive limits
Lower: No data available
Upper: No data available
Density: No data available
Solubility: No data available
Section 10. STABILITY AND REACTIVITY
Stability: Stable under proper conditions.
Reactivity: No special reactivity has been reported.
Incompartible materials: oxidizing agents
p-Benzanisidide
Section 10. STABILITY AND REACTIVITY
Hazardous Decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
Products:
Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available
Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobillity in soil
log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):
Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
Not Listed
UN-No:
Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.
p-Benzanisidide
SECTION 16 - ADDITIONAL INFORMATION
N/A
SAFETY DATA SHEET
Section 1. BASE INFORMATION
Product name: p-Benzanisidide
Revision number: 1
Section 2. HAZARDS IDENTIFICATION
Classification of the GHS
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS Not classified
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements
None
Pictograms or hazard symbols
Signal word No signal word
None
Hazard statement
Precautionary statements None
Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Component(s): p-Benzanisidide
Percent: >98.0%(GC)(T)
CAS Number: 7472-54-0
Synonyms: N-Benzoyl-p-anisidine , 4'-Methoxybenzanilide , N-(4-Methoxyphenyl)benzamide
Chemical Formula: C14H13NO2
Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.
Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
p-Benzanisidide
Section 5. FIRE-FIGHTING MEASURES
Specific methods: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:
Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.
Section 7. HANDLING AND STORAGE
Handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Law is followed.
Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.
Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Form: crystal - powder
Color: White - Pale yellow red
Odor: No data available
pH: No data available
Melting point/freezing point:155 °C
Boiling Point/Range: No data available
Flash Point: No data available
Explosive limits
Lower: No data available
Upper: No data available
Density: No data available
Solubility: No data available
Section 10. STABILITY AND REACTIVITY
Stability: Stable under proper conditions.
Reactivity: No special reactivity has been reported.
Incompartible materials: oxidizing agents
p-Benzanisidide
Section 10. STABILITY AND REACTIVITY
Hazardous Decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
Products:
Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available
Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobillity in soil
log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):
Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
Not Listed
UN-No:
Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26,
2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were
prescribed.
p-Benzanisidide
SECTION 16 - ADDITIONAL INFORMATION
N/A
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 N-苯甲酰替苯胺 N-phenyl benzoyl amide 93-98-1 C13H11NO 197.236 —— N-(4-methoxyphenyl)-N-methyl-benzamide 33675-68-2 C15H15NO2 241.29 2-碘-N-(4-甲氧基苯基)苯甲酰胺 2-iodo-N-(4-methoxyphenyl)benzamide 36684-49-8 C14H12INO2 353.159 2-氟-N-(4-甲氧基苯基)苯甲酰胺 2-fluoro-N-(4-methoxyphenyl)benzamide 212209-96-6 C14H12FNO2 245.253 2-溴-N-(4-甲氧基苯基)苯甲酰胺 2-bromo-N-(4-methoxyphenyl)benzamide 55204-50-7 C14H12BrNO2 306.159 2-巯基-N-(对甲氧基苯基)苯甲酰胺 2-mercapto-N-(p-methoxyphenyl)benzamide 92199-75-2 C14H13NO2S 259.329 N-[4-(三氟甲基)苯基]苯甲酰胺 N-(4-(trifluoromethyl)phenyl)benzamide 350-98-1 C14H10F3NO 265.235 N-甲基-N-苯基苯甲酰胺 N-methyl-N-phenyl-benzamide 1934-92-5 C14H13NO 211.263 N-(4-甲氧基苯基)苯硫代甲酰胺 N-(4-methoxyphenyl)benzothioamide 5310-26-9 C14H13NOS 243.329 N-烯丙基-N-(4-甲氧基苯基)苯甲酰胺 N-allyl-N-(4-methoxyphenyl)benzamide 71954-45-5 C17H17NO2 267.327 4-甲氧基-N,N-二苄基苯胺 N,N-dibenzyl-4-anisidine 18613-55-3 C21H21NO 303.404 N-苯甲酰苯基羟胺 N-phenylbenzohydroxamic acid 304-88-1 C13H11NO2 213.236 —— 2-(4-methyloxyphenylamino)-2-phenylacetonitrile 32323-74-3 C15H14N2O 238.289 2-(4-甲氧基苯基)异吲哚-1,3-二酮 2-(4-methoxyphenyl)isoindoline-1,3-dione 2142-04-3 C15H11NO3 253.257 —— N-(4-tert-butyldimethylsiloxybenzyl)-N-(4-methoxyphenyl)benzamide 1341219-55-3 C27H33NO3Si 447.649 —— N-(4-hydroxy-2-methoxybenzyl)-p-benzanisidide 1341219-51-9 C22H21NO4 363.413 4'-甲氧基甲酰苯胺 4-methoxyformanilide 5470-34-8 C8H9NO2 151.165 - 1
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 4-(N-苯甲酰基氨基)苯酚 p-benzoylaminophenol 15457-50-8 C13H11NO2 213.236 N-苯甲酰替苯胺 N-phenyl benzoyl amide 93-98-1 C13H11NO 197.236 —— N-(4-methoxyphenyl)-N-methyl-benzamide 33675-68-2 C15H15NO2 241.29 N-苄基-4-甲氧基苯胺 N-benzyl-p-anisidine 17377-95-6 C14H15NO 213.279 N-(4-甲氧基苯基)-N-苯基苯甲酰胺 N-(4-methoxyphenyl)-N-phenylbenzamide 73333-81-0 C20H17NO2 303.36 —— 4-(benzoylamino)phenyl methanesulfonate 73153-59-0 C14H13NO4S 291.328 N-[4-(三氟甲基)苯基]苯甲酰胺 N-(4-(trifluoromethyl)phenyl)benzamide 350-98-1 C14H10F3NO 265.235 N-(4-甲氧基苯基)苯硫代甲酰胺 N-(4-methoxyphenyl)benzothioamide 5310-26-9 C14H13NOS 243.329 N-烯丙基-N-(4-甲氧基苯基)苯甲酰胺 N-allyl-N-(4-methoxyphenyl)benzamide 71954-45-5 C17H17NO2 267.327 —— 2-acetamido-N-(4-methoxyphenyl)benzamide 59525-22-3 C16H16N2O3 284.315 —— N-Benzoyl-N-(4-methoxyphenyl)glycine 28794-25-4 C16H15NO4 285.299 N-(4-甲氧基-2-硝基苯基)苯甲酰胺 N-(4-methoxy-2-nitrophenyl)benzamide 38259-63-1 C14H12N2O4 272.26 苯甲基苯胺 N-Benzylaniline 103-32-2 C13H13N 183.253 - 1
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反应信息
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作为反应物：参考文献：名称：铜催化轻度硝化保护苯胺摘要：通过使用一当量的硝酸作为硝化剂，已开发出一种实用的铜催化的被保护的苯胺直接硝化方法。该程序的特点是反应条件温和，结构范围广（就N保护基和芳烃取代而言）以及高官能团耐受性。用两当量的硝酸进行消解也是可行的。DOI：10.1002/chem.201404000
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作为产物：描述：参考文献：名称：钯催化的醛亚胺氧化成酰胺摘要：通过亚胺的直接氧化合成酰胺的方法鲜有报道。在这里，我们报告了一种通过瓦克型反应使用廉价的叔丁基氢过氧化物水溶液作为氧化剂将亚胺催化氧化为酰胺衍生物的有效方法。该方法实用方便且显示出高官能团耐受性，允许各种亚胺以中等至良好的产率转化为相应的酰胺衍生物。